SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c0z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JB7_B_ACTB1169_0 (HYPOTHETICAL PROTEIN PAE2307)	2c0z	NOVW (Streptomyces niveus)	3 / 3	ARG A 2 ARG A 109 ARG A -3	None EDO A1192 (-4.1A) EDO A1192 (-4.0A)	1.09A	2jb7A-2c0zA: undetectable 2jb7B-2c0zA: undetectable 2jb7C-2c0zA: undetectable	2jb7A-2c0zA: 21.30 2jb7B-2c0zA: 21.30 2jb7C-2c0zA: 21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JB7_B_ACTB1169_0 (HYPOTHETICAL PROTEIN PAE2307)	2c0z	NOVW (Streptomyces niveus)	3 / 3	ARG A -3 ARG A 2 ARG A 109	EDO A1192 (-4.0A) None EDO A1192 (-4.1A)	1.12A	2jb7A-2c0zA: undetectable 2jb7B-2c0zA: undetectable 2jb7C-2c0zA: undetectable	2jb7A-2c0zA: 21.30 2jb7B-2c0zA: 21.30 2jb7C-2c0zA: 21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JB7_B_ACTB1169_0 (HYPOTHETICAL PROTEIN PAE2307)	2c0z	NOVW (Streptomyces niveus)	3 / 3	ARG A 109 ARG A -3 ARG A 2	EDO A1192 (-4.1A) EDO A1192 (-4.0A) None	1.07A	2jb7A-2c0zA: undetectable 2jb7B-2c0zA: undetectable 2jb7C-2c0zA: undetectable	2jb7A-2c0zA: 21.30 2jb7B-2c0zA: 21.30 2jb7C-2c0zA: 21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2UYQ_A_SAMA1311_0 (HYPOTHETICAL PROTEIN ML2640)	2c0z	NOVW (Streptomyces niveus)	5 / 7	GLY A 120 VAL A 84 ASP A 87 LEU A 88 ARG A 89	None	1.19A	2uyqA-2c0zA: undetectable	2uyqA-2c0zA: 22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L1A_A_AB1A101_2 (MDR769 HIV-1 PROTEASE)	2c0z	NOVW (Streptomyces niveus)	4 / 6	ASP A 168 GLY A 120 PRO A 158 THR A 159	SO4 A1191 ( 4.3A) None None None	0.88A	4l1aB-2c0zA: undetectable	4l1aB-2c0zA: 20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DV4_A_NMYA601_1 (CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 6-LIKE)	2c0z	NOVW (Streptomyces niveus)	5 / 12	LEU A 130 TYR A 132 ASP A 168 LEU A 153 HIS A 62	None None SO4 A1191 ( 4.3A) None None	1.08A	5dv4A-2c0zA: undetectable	5dv4A-2c0zA: 20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_V_BEZV801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 BEZ-LEU-LEU)	2c0z	NOVW (Streptomyces niveus)	4 / 4	ILE A 8 ILE A 117 ARG A 89 LEU A 6	None	1.31A	5dzkh-2c0zA: undetectable 5dzkn-2c0zA: undetectable 5dzkv-2c0zA: undetectable	5dzkh-2c0zA: 21.27 5dzkn-2c0zA: 21.27 5dzkv-2c0zA: 1.16

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2JB7_B_ACTB1169_0","HYPOTHETICAL PROTEIN PAE2307","2c0z","NOVW","Streptomyces niveus",3,"ARG A   2;ARG A 109;ARG A  -3","None;EDO A1192 (-4.1A);EDO A1192 (-4.0A)","1.09A","2jb7A-2c0zA:undetectable;2jb7B-2c0zA:undetectable;2jb7C-2c0zA:undetectable","2jb7A-2c0zA:21.30;2jb7B-2c0zA:21.30;2jb7C-2c0zA:21.30"],["2JB7_B_ACTB1169_0","HYPOTHETICAL PROTEIN PAE2307","2c0z","NOVW","Streptomyces niveus",3,"ARG A  -3;ARG A   2;ARG A 109","EDO A1192 (-4.0A);None;EDO A1192 (-4.1A)","1.12A","2jb7A-2c0zA:undetectable;2jb7B-2c0zA:undetectable;2jb7C-2c0zA:undetectable","2jb7A-2c0zA:21.30;2jb7B-2c0zA:21.30;2jb7C-2c0zA:21.30"],["2JB7_B_ACTB1169_0","HYPOTHETICAL PROTEIN PAE2307","2c0z","NOVW","Streptomyces niveus",3,"ARG A 109;ARG A  -3;ARG A   2","EDO A1192 (-4.1A);EDO A1192 (-4.0A);None","1.07A","2jb7A-2c0zA:undetectable;2jb7B-2c0zA:undetectable;2jb7C-2c0zA:undetectable","2jb7A-2c0zA:21.30;2jb7B-2c0zA:21.30;2jb7C-2c0zA:21.30"],["2UYQ_A_SAMA1311_0","HYPOTHETICAL PROTEIN ML2640","2c0z","NOVW","Streptomyces niveus",5,"GLY A 120;VAL A  84;ASP A  87;LEU A  88;ARG A  89","None","1.19A","2uyqA-2c0zA:undetectable","2uyqA-2c0zA:22.85"],["4L1A_A_AB1A101_2","MDR769 HIV-1 PROTEASE;MDR769 HIV-1 PROTEASE","2c0z","NOVW","Streptomyces niveus",4,"ASP A 168;GLY A 120;PRO A 158;THR A 159","SO4 A1191 ( 4.3A);None;None;None","0.88A","4l1aB-2c0zA:undetectable","4l1aB-2c0zA:20.40"],["5DV4_A_NMYA601_1","CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 6-LIKE","2c0z","NOVW","Streptomyces niveus",5,"LEU A 130;TYR A 132;ASP A 168;LEU A 153;HIS A  62","None;None;SO4 A1191 ( 4.3A);None;None","1.08A","5dv4A-2c0zA:undetectable","5dv4A-2c0zA:20.40"],["5DZK_V_BEZV801_0","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1;BEZ-LEU-LEU","2c0z","NOVW","Streptomyces niveus",4,"ILE A   8;ILE A 117;ARG A  89;LEU A   6","None","1.31A","5dzkh-2c0zA:undetectable;5dzkn-2c0zA:undetectable;5dzkv-2c0zA:undetectable","5dzkh-2c0zA:21.27;5dzkn-2c0zA:21.27;5dzkv-2c0zA:1.16"]]