SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c11'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
4 / 7 HIS A 167
LEU A 164
ASP A 652
PHE A 129
CU  A1742 (-3.2A)
None
None
None
1.07A 1ismB-2c11A:
undetectable
1ismB-2c11A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
4 / 7 HIS A 242
LEU A 516
SER A 497
PHE A 501
None
0.98A 1ismB-2c11A:
undetectable
1ismB-2c11A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_A_DAHA382_1
(AMINE OXIDASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
8 / 10 TYR A 372
THR A 467
ASN A 470
ASP A 472
TYR A 473
HIS A 520
HIS A 522
HIS A 684
None
PAQ  A 471 ( 4.4A)
PAQ  A 471 ( 3.3A)
PAQ  A 471 ( 3.6A)
PAQ  A 471 ( 4.5A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
CU  A1737 (-3.1A)
0.66A 1ivvA-2c11A:
39.3
1ivvA-2c11A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_B_DAHB382_1
(AMINE OXIDASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
8 / 10 TYR A 372
THR A 467
ASN A 470
ASP A 472
TYR A 473
HIS A 520
HIS A 522
HIS A 684
None
PAQ  A 471 ( 4.4A)
PAQ  A 471 ( 3.3A)
PAQ  A 471 ( 3.6A)
PAQ  A 471 ( 4.5A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
CU  A1737 (-3.1A)
0.69A 1ivvB-2c11A:
39.3
1ivvB-2c11A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
5 / 12 PHE A 703
ILE A 485
THR A 635
LEU A 632
ILE A 605
None
None
CA  A1738 ( 4.8A)
None
None
1.22A 1kqwA-2c11A:
undetectable
1kqwA-2c11A:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJO_A_CUA701_0
(PHENYLETHYLAMINE
OXIDASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 520
HIS A 522
HIS A 684
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
CU  A1737 (-3.1A)
0.24A 1rjoA-2c11A:
39.2
1rjoA-2c11A:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RKY_A_CUA801_0
(LYSYL OXIDASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 520
HIS A 522
HIS A 684
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
CU  A1737 (-3.1A)
0.27A 1rkyA-2c11A:
42.0
1rkyA-2c11A:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
5 / 12 LEU A 274
LEU A 277
LEU A 195
ILE A 183
THR A 210
None
1.22A 1tw4B-2c11A:
undetectable
1tw4B-2c11A:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.53A 1v54A-2c11A:
undetectable
1v54A-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.54A 1v54N-2c11A:
undetectable
1v54N-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_A_CUA517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.56A 1v55A-2c11A:
undetectable
1v55A-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_N_CUN517_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.57A 1v55N-2c11A:
undetectable
1v55N-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 520
HIS A 522
HIS A 684
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
CU  A1737 (-3.1A)
0.26A 1w2zA-2c11A:
44.8
1w2zA-2c11A:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_B_CUB701_0
(AMINE OXIDASE,
COPPER CONTAINING)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 520
HIS A 522
HIS A 684
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
CU  A1737 (-3.1A)
0.26A 1w2zB-2c11A:
44.7
1w2zB-2c11A:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_C_CUC701_0
(AMINE OXIDASE,
COPPER CONTAINING)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 520
HIS A 522
HIS A 684
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
CU  A1737 (-3.1A)
0.26A 1w2zC-2c11A:
44.8
1w2zC-2c11A:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_D_CUD701_0
(AMINE OXIDASE,
COPPER CONTAINING)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 520
HIS A 522
HIS A 684
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
CU  A1737 (-3.1A)
0.27A 1w2zD-2c11A:
45.3
1w2zD-2c11A:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
5 / 12 GLU A 367
ALA A 214
GLY A 390
GLY A 387
LEU A 365
None
1.06A 1x1aA-2c11A:
undetectable
1x1aA-2c11A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
4 / 8 HIS A 520
GLY A 517
PHE A 682
ASN A 470
CU  A1737 (-3.4A)
None
None
PAQ  A 471 ( 3.3A)
0.88A 2a8tB-2c11A:
undetectable
2a8tB-2c11A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
5 / 11 THR A 657
GLU A 140
ALA A 343
PRO A 170
PHE A 129
None
CU  A1741 (-2.7A)
None
None
None
1.25A 2admB-2c11A:
undetectable
2admB-2c11A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.52A 2dyrA-2c11A:
undetectable
2dyrA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.54A 2dyrN-2c11A:
undetectable
2dyrN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.49A 2dysA-2c11A:
undetectable
2dysA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.45A 2dysN-2c11A:
undetectable
2dysN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.53A 2eijA-2c11A:
undetectable
2eijA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.55A 2eijN-2c11A:
undetectable
2eijN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.51A 2eikA-2c11A:
undetectable
2eikA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.55A 2eikN-2c11A:
undetectable
2eikN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.49A 2eilA-2c11A:
undetectable
2eilA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.54A 2eilN-2c11A:
undetectable
2eilN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.58A 2eimA-2c11A:
undetectable
2eimA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.54A 2eimN-2c11A:
undetectable
2eimN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.44A 2einA-2c11A:
undetectable
2einA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.56A 2einN-2c11A:
undetectable
2einN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_D_TPFD2473_1
(CYTOCHROME P450 121)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
5 / 10 THR A 156
VAL A 155
ALA A 126
SER A  98
PHE A 344
NAG  A1730 ( 4.3A)
None
None
None
None
1.35A 2ij7D-2c11A:
0.0
2ij7D-2c11A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_A_CUA801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 520
HIS A 522
HIS A 684
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
CU  A1737 (-3.1A)
0.20A 2oqeA-2c11A:
42.3
2oqeA-2c11A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_B_CUB801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 520
HIS A 522
HIS A 684
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
CU  A1737 (-3.1A)
0.20A 2oqeB-2c11A:
41.9
2oqeB-2c11A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_C_CUC801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 520
HIS A 522
HIS A 684
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
CU  A1737 (-3.1A)
0.20A 2oqeC-2c11A:
42.3
2oqeC-2c11A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_D_CUD801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 520
HIS A 522
HIS A 684
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
CU  A1737 (-3.1A)
0.21A 2oqeD-2c11A:
42.0
2oqeD-2c11A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OQE_F_CUF801_0
(PEROXISOMAL COPPER
AMINE OXIDASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 520
HIS A 522
HIS A 684
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
CU  A1737 (-3.1A)
0.21A 2oqeF-2c11A:
42.0
2oqeF-2c11A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
4 / 4 SER A 220
GLY A 221
HIS A 160
ASP A 154
None
CU  A1742 ( 4.5A)
CU  A1741 (-3.5A)
NAG  A1731 ( 4.1A)
1.26A 2oxtC-2c11A:
undetectable
2oxtC-2c11A:
16.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
6 / 7 ALA A 370
TYR A 372
TYR A 384
ASP A 386
TYR A 473
HIS A 522
PAQ  A 471 ( 3.2A)
None
PAQ  A 471 ( 3.6A)
PAQ  A 471 ( 2.6A)
PAQ  A 471 ( 4.5A)
CU  A1737 (-3.1A)
0.32A 2pncA-2c11A:
55.2
2pncA-2c11A:
81.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
5 / 6 ALA A 370
TYR A 384
ASP A 386
TYR A 473
HIS A 522
PAQ  A 471 ( 3.2A)
PAQ  A 471 ( 3.6A)
PAQ  A 471 ( 2.6A)
PAQ  A 471 ( 4.5A)
CU  A1737 (-3.1A)
0.31A 2pncB-2c11A:
58.1
2pncB-2c11A:
81.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_A_CUA801_0
(COPPER AMINE OXIDASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 520
HIS A 522
HIS A 684
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
CU  A1737 (-3.1A)
0.25A 2w0qA-2c11A:
40.2
2w0qA-2c11A:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W0Q_B_CUB801_0
(COPPER AMINE OXIDASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 520
HIS A 522
HIS A 684
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
CU  A1737 (-3.1A)
0.25A 2w0qB-2c11A:
42.1
2w0qB-2c11A:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.60A 2y69A-2c11A:
undetectable
2y69A-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.63A 2y69N-2c11A:
undetectable
2y69N-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.58A 2zxwA-2c11A:
undetectable
2zxwA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.56A 2zxwN-2c11A:
undetectable
2zxwN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.58A 3abkA-2c11A:
undetectable
3abkA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.60A 3abkN-2c11A:
undetectable
3abkN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.55A 3ablA-2c11A:
undetectable
3ablA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.53A 3ablN-2c11A:
undetectable
3ablN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.60A 3abmA-2c11A:
undetectable
3abmA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.56A 3abmN-2c11A:
undetectable
3abmN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.61A 3ag1A-2c11A:
undetectable
3ag1A-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.63A 3ag1N-2c11A:
undetectable
3ag1N-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.59A 3ag2A-2c11A:
undetectable
3ag2A-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.59A 3ag2N-2c11A:
undetectable
3ag2N-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.59A 3ag3A-2c11A:
undetectable
3ag3A-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.60A 3ag3N-2c11A:
undetectable
3ag3N-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.69A 3ag4A-2c11A:
undetectable
3ag4A-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.67A 3ag4N-2c11A:
undetectable
3ag4N-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.57A 3asnA-2c11A:
undetectable
3asnA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.59A 3asnN-2c11A:
undetectable
3asnN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.57A 3asoA-2c11A:
undetectable
3asoA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.57A 3asoN-2c11A:
undetectable
3asoN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVD_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.71A 3bvdA-2c11A:
undetectable
3bvdA-2c11A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_A_CUA1023_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.65A 3dtuA-2c11A:
undetectable
3dtuA-2c11A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_CUC569_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.64A 3dtuC-2c11A:
undetectable
3dtuC-2c11A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
4 / 5 LEU A 194
GLN A 190
LEU A 277
GLU A 278
None
1.12A 3h5gA-2c11A:
undetectable
3h5gB-2c11A:
undetectable
3h5gA-2c11A:
3.42
3h5gB-2c11A:
3.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HII_A_CUA801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 520
HIS A 522
HIS A 684
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
CU  A1737 (-3.1A)
0.17A 3hiiA-2c11A:
53.5
3hiiA-2c11A:
39.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
5 / 12 TYR A 176
TYR A 384
ASP A 386
GLY A 390
ASN A 470
None
PAQ  A 471 ( 3.6A)
PAQ  A 471 ( 2.6A)
None
PAQ  A 471 ( 3.3A)
0.82A 3hiiA-2c11A:
53.5
3hiiA-2c11A:
39.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HII_B_CUB801_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 520
HIS A 522
HIS A 684
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
CU  A1737 (-3.1A)
0.18A 3hiiB-2c11A:
51.4
3hiiB-2c11A:
39.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
5 / 12 TYR A 176
TYR A 384
ASP A 386
GLY A 390
ASN A 470
None
PAQ  A 471 ( 3.6A)
PAQ  A 471 ( 2.6A)
None
PAQ  A 471 ( 3.3A)
0.78A 3hiiB-2c11A:
51.4
3hiiB-2c11A:
39.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
4 / 8 PRO A 215
GLY A 217
PRO A 653
SER A 620
None
0.86A 3lslA-2c11A:
undetectable
3lslD-2c11A:
undetectable
3lslA-2c11A:
15.31
3lslD-2c11A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
4 / 8 PRO A 653
SER A 620
PRO A 215
GLY A 217
None
0.85A 3lslA-2c11A:
undetectable
3lslD-2c11A:
undetectable
3lslA-2c11A:
15.31
3lslD-2c11A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
4 / 6 LEU A  63
GLU A  67
PRO A 147
HIS A 414
None
None
None
CU  A1743 (-3.3A)
1.48A 3ltwA-2c11A:
undetectable
3ltwA-2c11A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
5 / 12 TYR A 603
GLU A 486
ILE A 487
PHE A 526
ILE A 363
None
1.20A 3ndiA-2c11A:
undetectable
3ndiA-2c11A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_2
(YAEB-LIKE PROTEIN
RPA0152)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
4 / 5 HIS A 525
SER A 645
ARG A 383
THR A 679
None
None
CL  A1739 (-4.6A)
None
1.35A 3okxB-2c11A:
0.0
3okxB-2c11A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S33_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.63A 3s33A-2c11A:
undetectable
3s33A-2c11A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S38_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.67A 3s38A-2c11A:
undetectable
3s38A-2c11A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S39_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.60A 3s39A-2c11A:
undetectable
3s39A-2c11A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3A_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.68A 3s3aA-2c11A:
undetectable
3s3aA-2c11A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3B_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.62A 3s3bA-2c11A:
undetectable
3s3bA-2c11A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3C_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.65A 3s3cA-2c11A:
undetectable
3s3cA-2c11A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3D_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.59A 3s3dA-2c11A:
undetectable
3s3dA-2c11A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
5 / 12 VAL A 352
ASP A 351
GLY A 116
ALA A 109
ALA A 108
None
1.03A 3sudD-2c11A:
undetectable
3sudD-2c11A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
5 / 12 VAL A 352
ASP A 351
GLY A 116
ALA A 109
ALA A 108
None
1.00A 3sueC-2c11A:
undetectable
3sueC-2c11A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
5 / 12 GLN A 650
GLU A 367
GLY A 390
GLY A 346
GLY A 387
None
1.07A 3tegA-2c11A:
undetectable
3tegA-2c11A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
4 / 8 VAL A 171
HIS A 251
PRO A 653
TRP A 654
None
1.23A 3v35A-2c11A:
undetectable
3v35A-2c11A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 LYS A 638
GLU A 641
TRP A 677
CA  A1738 (-2.7A)
CA  A1738 ( 3.9A)
None
1.43A 3v4tH-2c11A:
undetectable
3v4tH-2c11A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_2
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
4 / 4 PRO A 686
LEU A 516
HIS A 242
LEU A 229
None
1.24A 3vw7A-2c11A:
0.0
3vw7A-2c11A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.54A 3wg7A-2c11A:
undetectable
3wg7A-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.56A 3wg7N-2c11A:
undetectable
3wg7N-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_A_CUA604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.56A 3x2qA-2c11A:
undetectable
3x2qA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.60A 3x2qN-2c11A:
undetectable
3x2qN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
4 / 8 ASP A 662
PHE A 660
VAL A 675
GLN A 366
None
0.87A 4acbB-2c11A:
undetectable
4acbC-2c11A:
undetectable
4acbB-2c11A:
19.25
4acbC-2c11A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
4 / 6 ARG A 585
LEU A 562
MET A 544
ASP A 543
None
1.47A 4cevA-2c11A:
undetectable
4cevB-2c11A:
undetectable
4cevA-2c11A:
16.53
4cevB-2c11A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
4 / 6 MET A 544
ASP A 543
ARG A 585
LEU A 562
None
1.47A 4cevA-2c11A:
undetectable
4cevC-2c11A:
undetectable
4cevA-2c11A:
16.53
4cevC-2c11A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
4 / 6 ARG A 585
LEU A 562
MET A 544
ASP A 543
None
1.44A 4cevD-2c11A:
undetectable
4cevE-2c11A:
undetectable
4cevD-2c11A:
16.53
4cevE-2c11A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
4 / 6 ARG A 585
LEU A 562
MET A 544
ASP A 543
None
1.47A 4cevE-2c11A:
undetectable
4cevF-2c11A:
undetectable
4cevE-2c11A:
16.53
4cevF-2c11A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 GLY A 221
SER A 220
TRP A 654
CU  A1742 ( 4.5A)
None
None
0.73A 4e7cD-2c11A:
undetectable
4e7cD-2c11A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
5 / 11 HIS A 160
PHE A  97
GLY A 390
TYR A 394
GLU A 367
CU  A1741 (-3.5A)
None
None
None
None
1.33A 4fglA-2c11A:
undetectable
4fglB-2c11A:
undetectable
4fglA-2c11A:
15.06
4fglB-2c11A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_A_LYAA304_1
(FOLATE RECEPTOR BETA)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
5 / 12 ASP A 476
THR A 477
SER A 644
GLY A 390
TYR A 490
None
1.40A 4kn2A-2c11A:
0.0
4kn2A-2c11A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_1
(FOLATE RECEPTOR BETA)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
5 / 12 ASP A 476
THR A 477
SER A 644
GLY A 390
TYR A 490
None
1.39A 4kn2C-2c11A:
0.0
4kn2C-2c11A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
4 / 6 GLU A 100
VAL A 155
THR A 156
ARG A 159
None
None
NAG  A1730 ( 4.3A)
None
1.25A 4lnxA-2c11A:
undetectable
4lnxA-2c11A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
4 / 7 HIS A 112
PRO A 119
SER A 338
PHE A  60
CU  A1740 (-3.5A)
None
None
None
1.22A 4odjA-2c11A:
undetectable
4odjA-2c11A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
5 / 12 PHE A 526
TYR A 473
VAL A 701
GLY A 702
SER A 609
None
PAQ  A 471 ( 4.5A)
None
None
None
1.34A 4ot2A-2c11A:
undetectable
4ot2A-2c11A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 LYS A 106
ARG A 353
VAL A 352
CA  A1736 ( 3.7A)
None
None
1.03A 4x3uA-2c11A:
0.7
4x3uB-2c11A:
0.6
4x3uA-2c11A:
6.68
4x3uB-2c11A:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
5 / 12 ALA A 676
VAL A 678
VAL A 352
GLU A 486
PHE A 479
None
1.27A 4zj8A-2c11A:
undetectable
4zj8A-2c11A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
4 / 8 SER A 345
GLY A 346
ALA A  61
GLY A 340
None
0.77A 5albL-2c11A:
undetectable
5albL-2c11A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.54A 5b1aA-2c11A:
undetectable
5b1aA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.57A 5b1aN-2c11A:
undetectable
5b1aN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.59A 5b1bA-2c11A:
undetectable
5b1bA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.59A 5b1bN-2c11A:
undetectable
5b1bN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.57A 5b3sA-2c11A:
undetectable
5b3sA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.59A 5b3sN-2c11A:
undetectable
5b3sN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
5 / 12 TYR A 394
LEU A 468
ALA A 368
ILE A 127
SER A 645
None
PAQ  A 471 ( 3.4A)
None
None
None
1.13A 5h8tA-2c11A:
undetectable
5h8tA-2c11A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.59A 5iy5A-2c11A:
undetectable
5iy5A-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.59A 5iy5N-2c11A:
undetectable
5iy5N-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
5 / 12 GLY A 144
ASP A 154
VAL A 155
THR A 156
LEU A 125
None
NAG  A1731 ( 4.1A)
None
NAG  A1730 ( 4.3A)
None
0.73A 5kocA-2c11A:
undetectable
5kocA-2c11A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
4 / 7 ILE A 179
ILE A 183
MET A 182
ILE A 261
None
0.82A 5murB-2c11A:
undetectable
5murB-2c11A:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
4 / 6 ARG A 348
PHE A 337
PHE A 350
ILE A 363
None
1.10A 5vceA-2c11A:
undetectable
5vceA-2c11A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.66A 5w97a-2c11A:
undetectable
5w97a-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.63A 5waua-2c11A:
undetectable
5waua-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 THR A 213
THR A 225
ARG A 216
None
0.88A 5wm2A-2c11A:
undetectable
5wm2A-2c11A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.60A 5x19A-2c11A:
undetectable
5x19A-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.63A 5x19N-2c11A:
undetectable
5x19N-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.63A 5x1bA-2c11A:
undetectable
5x1bA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.64A 5x1bN-2c11A:
undetectable
5x1bN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.64A 5x1fA-2c11A:
undetectable
5x1fA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.63A 5x1fN-2c11A:
undetectable
5x1fN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.58A 5xdqA-2c11A:
undetectable
5xdqA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.60A 5xdqN-2c11A:
undetectable
5xdqN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.61A 5xdxA-2c11A:
undetectable
5xdxA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.62A 5xdxN-2c11A:
undetectable
5xdxN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
4 / 7 GLY A 517
GLY A 508
ASN A 693
THR A 694
None
0.65A 5ybbB-2c11A:
undetectable
5ybbB-2c11A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.53A 5z84A-2c11A:
undetectable
5z84A-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.56A 5z84N-2c11A:
undetectable
5z84N-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.56A 5z85A-2c11A:
undetectable
5z85A-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.54A 5z85N-2c11A:
undetectable
5z85N-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.55A 5z86A-2c11A:
undetectable
5z86A-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.60A 5z86N-2c11A:
undetectable
5z86N-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.56A 5zcoA-2c11A:
undetectable
5zcoA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.53A 5zcoN-2c11A:
undetectable
5zcoN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.53A 5zcpA-2c11A:
undetectable
5zcpA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_N_CUN604_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.56A 5zcpN-2c11A:
undetectable
5zcpN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.52A 5zcqA-2c11A:
undetectable
5zcqA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.53A 5zcqN-2c11A:
undetectable
5zcqN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 TYR A 151
ALA A 126
LEU A 125
None
0.63A 6ag0C-2c11A:
undetectable
6ag0C-2c11A:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
4 / 6 GLU A  67
ARG A 122
GLU A 123
ALA A 124
None
1.24A 6an0A-2c11A:
undetectable
6an0A-2c11A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
5 / 12 LEU A 608
GLY A 702
LEU A 359
VAL A 360
ILE A 363
None
0.93A 6bxmA-2c11A:
undetectable
6bxmA-2c11A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
5 / 12 VAL A 352
ASP A 351
GLY A 116
ALA A 109
ALA A 108
None
1.00A 6c2mC-2c11A:
undetectable
6c2mC-2c11A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_B_NCTB402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
4 / 7 CSS A 199
CSS A 198
TYR A 266
LEU A 208
None
1.06A 6cnkB-2c11A:
undetectable
6cnkC-2c11A:
undetectable
6cnkB-2c11A:
8.35
6cnkC-2c11A:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
4 / 8 HIS A 112
PRO A 119
SER A 338
PHE A  60
CU  A1740 (-3.5A)
None
None
None
1.18A 6fbnB-2c11A:
undetectable
6fbnB-2c11A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.70A 6hu9a-2c11A:
undetectable
6hu9a-2c11A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
5 / 8 PHE A 625
HIS A 525
GLY A 681
SER A 523
ALA A 370
None
None
None
None
PAQ  A 471 ( 3.2A)
1.19A 6hu9H-2c11A:
undetectable
6hu9e-2c11A:
undetectable
6hu9H-2c11A:
8.31
6hu9e-2c11A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_M_CUM601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.68A 6hu9m-2c11A:
undetectable
6hu9m-2c11A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.57A 6nknA-2c11A:
undetectable
6nknA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_N_CUN602_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.57A 6nknN-2c11A:
undetectable
6nknN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_A_CUA603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.62A 6nmfA-2c11A:
undetectable
6nmfA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.67A 6nmfN-2c11A:
undetectable
6nmfN-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.64A 6nmpA-2c11A:
undetectable
6nmpA-2c11A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo
sapiens)
3 / 3 HIS A 684
HIS A 520
HIS A 522
CU  A1737 (-3.1A)
CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
0.63A 6nmpN-2c11A:
undetectable
6nmpN-2c11A:
21.37