SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c1c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		3 / 3 VAL A  79
TRP A  81
TRP A 294
 None
 1.47A 1c4dA-2c1cA:
undetectable
1c4dB-2c1cA:
undetectable		 1c4dA-2c1cA:
3.89
1c4dB-2c1cA:
3.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		4 / 6 LEU A 203
ASP A 256
MET A 195
LEU A 271
 None
 1.21A 1errB-2c1cA:
undetectable		 1errB-2c1cA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		5 / 8 ILE A  50
LEU A 107
ILE A  83
VAL A  87
ILE A  25
 None
 1.19A 1linA-2c1cA:
undetectable		 1linA-2c1cA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		5 / 10 GLY A 223
VAL A 222
LEU A 191
LEU A 193
TYR A 269
 None
 1.34A 1pbcA-2c1cA:
undetectable		 1pbcA-2c1cA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		5 / 10 GLY A 296
VAL A 299
GLY A 300
THR A 293
VAL A 229
 None
 1.07A 1pwyE-2c1cA:
6.2		 1pwyE-2c1cA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		5 / 10 GLY A 296
VAL A 299
GLY A 300
THR A 293
VAL A 229
 None
 1.15A 1v3qE-2c1cA:
7.1		 1v3qE-2c1cA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		5 / 12 HIS A 196
LEU A 108
SER A 260
PHE A  63
ILE A 182
 ZN  A 625 (-3.3A)
None
None
None
None
 1.23A 1xotA-2c1cA:
undetectable		 1xotA-2c1cA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_B_C2FB1420_0
(GLYCINE
N-METHYLTRANSFERASE)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		5 / 10 LEU A 191
SER A 243
TYR A 267
HIS A 259
TYR A 269
 None
 1.46A 2idkA-2c1cA:
0.0
2idkB-2c1cA:
0.0
2idkC-2c1cA:
0.5
2idkD-2c1cA:
0.1		 2idkA-2c1cA:
22.09
2idkB-2c1cA:
22.09
2idkC-2c1cA:
22.09
2idkD-2c1cA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		3 / 3 GLU A 270
HIS A  69
GLU A  72
 ZN  A 625 ( 4.6A)
ZN  A 625 (-3.0A)
ZN  A 625 (-2.2A)
 0.84A 2x45B-2c1cA:
undetectable		 2x45B-2c1cA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		3 / 3 GLU A 270
HIS A  69
GLU A  72
 ZN  A 625 ( 4.6A)
ZN  A 625 (-3.0A)
ZN  A 625 (-2.2A)
 0.88A 2x45C-2c1cA:
undetectable		 2x45C-2c1cA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		4 / 5 GLY A 305
ASP A 306
ARG A 302
MET A 195
 None
 0.96A 3qx3A-2c1cA:
3.0		 3qx3A-2c1cA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		4 / 5 GLY A 305
ASP A 306
ARG A 302
MET A 195
 None
 0.99A 3qx3B-2c1cA:
3.3		 3qx3B-2c1cA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		5 / 7 THR A 129
GLY A 115
PRO A 113
ASN A 112
GLY A  44
 None
 0.93A 3tajA-2c1cA:
undetectable		 3tajA-2c1cA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		4 / 5 THR A 129
GLY A 115
PRO A 113
ASN A 112
 None
 0.83A 3u8qA-2c1cA:
undetectable		 3u8qA-2c1cA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		5 / 12 PRO A 109
LEU A  22
ILE A  83
TYR A  21
GLN A  13
 None
 1.41A 4a83A-2c1cA:
undetectable		 4a83A-2c1cA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		5 / 6 THR A 129
GLY A 115
PRO A 113
ASN A 112
GLY A  44
 None
 0.89A 4fjpA-2c1cA:
undetectable		 4fjpA-2c1cA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		4 / 6 GLU A 292
THR A 293
THR A 268
HIS A 196
 None
None
None
ZN  A 625 (-3.3A)
 1.37A 4pfjB-2c1cA:
undetectable		 4pfjB-2c1cA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		4 / 8 ASN A 112
LEU A  15
PHE A  42
GLY A  44
 None
 0.83A 4r3aA-2c1cA:
1.7		 4r3aA-2c1cA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		4 / 4 THR A 194
GLY A 143
ASP A 142
SER A 254
 None
 1.31A 4rfqA-2c1cA:
undetectable		 4rfqA-2c1cA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		5 / 12 ASN A 112
GLU A 173
ALA A  39
ILE A  47
ARG A 177
 None
 1.20A 4uroC-2c1cA:
undetectable		 4uroC-2c1cA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		5 / 10 PHE A 198
TYR A 248
GLY A 277
SER A 197
GLY A 199
 None
 1.31A 4xpbA-2c1cA:
0.4		 4xpbA-2c1cA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC404_0
(PROTON-GATED ION
CHANNEL)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		4 / 4 ILE A 250
ILE A 164
ARG A 127
TYR A 248
 None
 1.23A 4zzbC-2c1cA:
1.1		 4zzbC-2c1cA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_C_ACTC407_0
(PROTON-GATED ION
CHANNEL)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		4 / 4 ILE A 250
ILE A 164
ARG A 127
TYR A 248
 None
 1.24A 4zzcC-2c1cA:
1.2		 4zzcC-2c1cA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_D_ACTD406_0
(PROTON-GATED ION
CHANNEL)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		4 / 4 ILE A 250
ILE A 164
ARG A 127
TYR A 248
 None
 1.24A 4zzcD-2c1cA:
1.1		 4zzcD-2c1cA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		4 / 5 ILE A 250
ILE A 164
ARG A 127
TYR A 248
 None
 1.24A 4zzcE-2c1cA:
undetectable		 4zzcE-2c1cA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		3 / 3 ASP A 306
VAL A 222
LEU A 265
 None
 0.56A 5e5jB-2c1cA:
undetectable		 5e5jB-2c1cA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		5 / 12 ILE A 202
TYR A 269
GLY A 218
GLY A 241
GLY A 300
 None
 1.20A 5i71A-2c1cA:
undetectable		 5i71A-2c1cA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		5 / 12 ILE A 202
TYR A 269
GLY A 218
GLY A 241
GLY A 300
 None
 1.20A 5i75A-2c1cA:
undetectable		 5i75A-2c1cA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		5 / 9 ILE A  64
VAL A 289
LEU A 271
ILE A  74
LEU A 191
 None
 1.24A 5iepA-2c1cA:
undetectable		 5iepA-2c1cA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		4 / 6 ILE A  18
LEU A  22
ILE A  83
TYR A   9
 None
 0.80A 5mvmB-2c1cA:
undetectable
5mvmC-2c1cA:
undetectable		 5mvmB-2c1cA:
12.62
5mvmC-2c1cA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		4 / 5 HIS A 196
ASP A 256
GLY A 252
ASN A 144
 ZN  A 625 (-3.3A)
None
None
None
 1.48A 5x7pB-2c1cA:
0.0		 5x7pB-2c1cA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		4 / 5 GLY A 305
ASP A 306
ARG A 302
MET A 195
 None
 0.90A 5zrfB-2c1cA:
3.2		 5zrfB-2c1cA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		4 / 4 GLY A 305
ASP A 306
ARG A 302
MET A 195
 None
 0.83A 5zrfA-2c1cA:
0.0		 5zrfA-2c1cA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		3 / 3 PHE A 103
ASP A 104
LYS A  59
 None
 0.72A 6awtD-2c1cA:
undetectable		 6awtD-2c1cA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		4 / 7 ILE A  83
LEU A  86
ILE A 182
ALA A 301
 None
 0.87A 6b5vA-2c1cA:
undetectable
6b5vC-2c1cA:
undetectable		 6b5vA-2c1cA:
12.79
6b5vC-2c1cA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		4 / 7 ALA A 301
ILE A  83
LEU A  86
ILE A 182
 None
 0.85A 6b5vA-2c1cA:
undetectable
6b5vB-2c1cA:
undetectable		 6b5vA-2c1cA:
12.79
6b5vB-2c1cA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		4 / 7 ILE A  83
LEU A  86
ILE A 182
ALA A 301
 None
 0.87A 6b5vC-2c1cA:
undetectable
6b5vD-2c1cA:
undetectable		 6b5vC-2c1cA:
12.79
6b5vD-2c1cA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		4 / 7 ASP A 209
ALA A 244
GLU A 255
LEU A 212
 None
 0.98A 6ci6A-2c1cA:
undetectable		 6ci6A-2c1cA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA717_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		4 / 5 SER A  53
ASP A 104
ARG A 188
LYS A  59
 None
 1.47A 6dwdA-2c1cA:
undetectable		 6dwdA-2c1cA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2c1c CARBOXYPEPTIDASE B
(Helicoverpa
zea) 		4 / 6 LEU A 274
LEU A 281
TYR A 238
LEU A 235
 None
 0.94A 6f6sA-2c1cA:
undetectable
6f6sB-2c1cA:
undetectable		 6f6sA-2c1cA:
15.72
6f6sB-2c1cA:
13.94