SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c1d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 2c1d SOXA
(Paracoccus
denitrificans) 		3 / 3 VAL A 288
VAL A 286
TRP A  65
 None
 0.96A 1bdwA-2c1dA:
undetectable
1bdwB-2c1dA:
undetectable		 1bdwA-2c1dA:
3.82
1bdwB-2c1dA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2c1d SOXX
(Paracoccus
pantotrophus) 		5 / 11 LEU B 152
GLU B  92
ARG B  96
MET B  53
ILE B  52
 HEC  B1158 ( 4.9A)
None
None
None
None
 1.27A 1g50A-2c1dB:
undetectable		 1g50A-2c1dB:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 2c1d SOXA
SOXX
(Paracoccus
denitrificans;
Paracoccus
pantotrophus) 		5 / 12 ARG A 219
GLY B  49
ILE B  52
VAL B  73
ILE B  67
 None
 0.87A 1muiB-2c1dA:
undetectable		 1muiB-2c1dA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2c1d SOXA
(Paracoccus
denitrificans) 		3 / 3 GLY A 215
ASP A  27
ASN A 213
 None
 0.58A 1vq1A-2c1dA:
undetectable		 1vq1A-2c1dA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 2c1d SOXA
(Paracoccus
denitrificans) 		3 / 3 THR A 243
THR A 233
PRO A 232
 None
HEC  A1292 ( 4.5A)
None
 0.86A 209dC-2c1dA:
undetectable		 209dC-2c1dA:
3.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 2c1d SOXA
SOXX
(Paracoccus
denitrificans;
Paracoccus
pantotrophus) 		5 / 11 ARG A 219
GLY B  49
ILE B  52
VAL B  73
ILE B  67
 None
 0.91A 2aquB-2c1dA:
undetectable		 2aquB-2c1dA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 2c1d SOXA
SOXX
(Paracoccus
denitrificans;
Paracoccus
pantotrophus) 		5 / 9 ARG A 219
GLY B  49
ILE B  52
VAL B  73
ILE B  67
 None
 0.95A 2avoA-2c1dA:
undetectable		 2avoA-2c1dA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 2c1d SOXX
(Paracoccus
pantotrophus) 		3 / 3 ASP B  88
ILE B  67
VAL B  99
 None
None
HEC  B1158 ( 4.6A)
 0.61A 2avvD-2c1dB:
undetectable		 2avvD-2c1dB:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 2c1d SOXA
SOXX
(Paracoccus
denitrificans;
Paracoccus
pantotrophus) 		5 / 11 ARG A 219
GLY B  49
ILE B  52
VAL B  73
ILE B  67
 None
 0.95A 2qhcA-2c1dA:
undetectable		 2qhcA-2c1dA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 2c1d SOXA
SOXX
(Paracoccus
denitrificans;
Paracoccus
pantotrophus) 		5 / 12 ARG A 219
GLY B  49
ILE B  52
VAL B  73
ILE B  67
 None
 0.87A 2r5pD-2c1dA:
undetectable		 2r5pD-2c1dA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 2c1d SOXA
SOXX
(Paracoccus
denitrificans;
Paracoccus
pantotrophus) 		5 / 9 ARG A 219
GLY B  49
ILE B  52
VAL B  73
ILE B  67
 None
 0.99A 2r5qA-2c1dA:
undetectable		 2r5qA-2c1dA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 2c1d SOXA
SOXX
(Paracoccus
denitrificans;
Paracoccus
pantotrophus) 		5 / 9 ARG A 219
GLY B  49
ILE B  52
VAL B  73
ILE B  67
 None
 0.99A 2r5qC-2c1dA:
undetectable		 2r5qC-2c1dA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 2c1d SOXA
(Paracoccus
denitrificans) 		3 / 3 SER A  63
THR A  48
PHE A  53
 None
 0.68A 2x91A-2c1dA:
undetectable		 2x91A-2c1dA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 2c1d SOXA
(Paracoccus
denitrificans) 		5 / 12 LEU A  33
VAL A 286
GLY A 285
ARG A 172
ILE A  35
 None
 1.18A 3bf1A-2c1dA:
undetectable
3bf1B-2c1dA:
undetectable		 3bf1A-2c1dA:
22.82
3bf1B-2c1dA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 2c1d SOXA
SOXX
(Paracoccus
denitrificans;
Paracoccus
pantotrophus) 		5 / 9 ARG A 219
GLY B  49
ILE B  52
VAL B  73
ILE B  67
 None
 1.08A 3ekyB-2c1dA:
undetectable		 3ekyB-2c1dA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2c1d SOXA
SOXX
(Paracoccus
denitrificans;
Paracoccus
pantotrophus) 		3 / 3 PRO B 138
LEU B 136
GLN A 201
 None
 0.65A 3hznG-2c1dB:
undetectable
3hznH-2c1dB:
undetectable		 3hznG-2c1dB:
22.81
3hznH-2c1dB:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 2c1d SOXA
(Paracoccus
denitrificans) 		4 / 8 ILE A  61
PRO A  51
SER A 276
GLY A 278
 None
 0.90A 3lslA-2c1dA:
undetectable
3lslD-2c1dA:
undetectable		 3lslA-2c1dA:
17.54
3lslD-2c1dA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 2c1d SOXA
(Paracoccus
denitrificans) 		4 / 8 ILE A  61
PRO A  51
SER A 276
GLY A 278
 None
 0.87A 3lslA-2c1dA:
undetectable
3lslD-2c1dA:
undetectable		 3lslA-2c1dA:
17.54
3lslD-2c1dA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 2c1d SOXA
(Paracoccus
denitrificans) 		3 / 3 ARG A  73
ARG A  68
TRP A  65
 None
HEC  A1292 (-3.1A)
None
 0.66A 4b7nA-2c1dA:
undetectable		 4b7nA-2c1dA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 2c1d SOXA
(Paracoccus
denitrificans) 		3 / 3 ARG A  73
ARG A  68
TRP A  65
 None
HEC  A1292 (-3.1A)
None
 0.67A 4cpzC-2c1dA:
undetectable		 4cpzC-2c1dA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 2c1d SOXA
(Paracoccus
denitrificans) 		3 / 3 ARG A  73
ARG A  68
TRP A  65
 None
HEC  A1292 (-3.1A)
None
 0.64A 4cpzE-2c1dA:
undetectable		 4cpzE-2c1dA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 2c1d SOXA
(Paracoccus
denitrificans) 		3 / 3 ARG A  73
ARG A  68
TRP A  65
 None
HEC  A1292 (-3.1A)
None
 0.69A 4cpzF-2c1dA:
undetectable		 4cpzF-2c1dA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 2c1d SOXA
(Paracoccus
denitrificans) 		3 / 3 ARG A  73
ARG A  68
TRP A  65
 None
HEC  A1292 (-3.1A)
None
 0.72A 4cpzG-2c1dA:
undetectable		 4cpzG-2c1dA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 2c1d SOXA
(Paracoccus
denitrificans) 		3 / 3 ARG A  73
ARG A  68
TRP A  65
 None
HEC  A1292 (-3.1A)
None
 0.64A 4cpzH-2c1dA:
undetectable		 4cpzH-2c1dA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 2c1d SOXA
SOXX
(Paracoccus
denitrificans;
Paracoccus
pantotrophus) 		5 / 11 ARG A 219
GLY B  49
ILE B  52
VAL B  73
ILE B  67
 None
 0.96A 4dqeA-2c1dA:
undetectable		 4dqeA-2c1dA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2c1d SOXA
SOXX
(Paracoccus
denitrificans;
Paracoccus
pantotrophus) 		4 / 5 LEU A 223
ARG A 247
ARG A  68
THR B  78
 HEC  A1292 (-4.9A)
HEC  A1292 (-3.4A)
HEC  A1292 (-3.1A)
None
 1.46A 4p3qA-2c1dA:
undetectable		 4p3qA-2c1dA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 2c1d SOXA
(Paracoccus
denitrificans) 		5 / 11 ALA A 214
VAL A 274
TYR A 195
GLY A  64
GLY A 278
 None
None
None
HEC  A1292 (-3.4A)
None
 1.09A 4xp4A-2c1dA:
undetectable		 4xp4A-2c1dA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 2c1d SOXA
(Paracoccus
denitrificans) 		4 / 4 VAL A 101
GLU A 104
GLY A 149
LEU A 150
 None
 1.10A 5g5gC-2c1dA:
undetectable		 5g5gC-2c1dA:
16.74