SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c1h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		5 / 11 GLU A 238
MET A 173
ILE A 143
GLY A 136
HIS A 134
 MG  A1329 (-2.8A)
None
None
None
None
 1.29A 1g50C-2c1hA:
undetectable		 1g50C-2c1hA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		3 / 3 THR A 187
LEU A 184
VAL A 192
 None
 0.64A 1mz9E-2c1hA:
undetectable		 1mz9E-2c1hA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		4 / 6 LEU A  76
MET A 301
MET A 300
LEU A  31
 None
 1.36A 2oz7A-2c1hA:
undetectable		 2oz7A-2c1hA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		5 / 12 ALA A  66
GLU A  69
LEU A  40
ILE A  86
GLY A  85
 None
 1.15A 2yjaB-2c1hA:
undetectable		 2yjaB-2c1hA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		3 / 3 ASP A  75
THR A  62
GLU A  69
 None
 0.78A 2zifB-2c1hA:
undetectable		 2zifB-2c1hA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		4 / 6 GLY A 102
SER A 158
ILE A 103
GLU A  96
 None
 0.68A 3a7eA-2c1hA:
undetectable		 3a7eA-2c1hA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		4 / 6 VAL A  67
LYS A  71
GLY A  77
ARG A 328
 None
 0.82A 3bjwE-2c1hA:
undetectable		 3bjwE-2c1hA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		4 / 7 VAL A  67
LYS A  71
GLY A  77
ARG A 328
 None
 0.83A 3bjwF-2c1hA:
undetectable		 3bjwF-2c1hA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		4 / 7 VAL A  67
LYS A  71
GLY A  77
ARG A 328
 None
 0.90A 3bjwH-2c1hA:
undetectable		 3bjwH-2c1hA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		4 / 7 TYR A 206
VAL A 278
THR A 265
GLY A 255
 DSB  A1330 (-4.0A)
DSB  A1330 (-3.6A)
None
None
 0.96A 3gssA-2c1hA:
undetectable		 3gssA-2c1hA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		5 / 12 GLY A 102
GLY A  85
ALA A  66
CYH A  70
ASP A  64
 None
 0.99A 3keeA-2c1hA:
undetectable		 3keeA-2c1hA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		5 / 9 GLY A 246
ALA A 247
ASP A 248
ILE A 249
ILE A 180
 None
 0.89A 3ogpA-2c1hA:
undetectable		 3ogpA-2c1hA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		4 / 5 HIS A 277
TYR A 319
TYR A 282
GLU A 296
 None
 1.47A 4ae1B-2c1hA:
undetectable		 4ae1B-2c1hA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		4 / 8 TYR A 276
PHE A 316
PHE A  84
ILE A 177
 DSB  A1330 (-3.9A)
None
None
None
 0.96A 4qoiA-2c1hA:
undetectable
4qoiB-2c1hA:
undetectable		 4qoiA-2c1hA:
22.94
4qoiB-2c1hA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		4 / 8 ALA A 110
ILE A 111
PHE A  61
LEU A  40
 None
 0.63A 4v1fA-2c1hA:
undetectable
4v1fB-2c1hA:
undetectable		 4v1fA-2c1hA:
17.83
4v1fB-2c1hA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		4 / 5 GLY A 102
SER A 158
GLU A  96
ASP A 100
 None
 1.20A 4xueA-2c1hA:
undetectable		 4xueA-2c1hA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		3 / 3 ARG A 176
ASP A 171
TYR A 197
 MG  A1329 (-4.2A)
None
None
 0.90A 4yo9B-2c1hA:
undetectable		 4yo9B-2c1hA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		5 / 11 ALA A  66
GLU A  69
LEU A  40
ILE A  86
GLY A  85
 None
 1.16A 5dxbB-2c1hA:
undetectable		 5dxbB-2c1hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		4 / 4 LEU A 195
ARG A 176
ILE A 194
ILE A 177
 None
MG  A1329 (-4.2A)
None
None
 1.37A 5dzk2-2c1hA:
undetectable
5dzkM-2c1hA:
1.0
5dzkN-2c1hA:
undetectable		 5dzk2-2c1hA:
28.57
5dzkM-2c1hA:
21.82
5dzkN-2c1hA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		3 / 3 ASP A  82
SER A 170
TYR A 197
 None
DSB  A1330 (-3.4A)
None
 0.89A 5glmA-2c1hA:
undetectable		 5glmA-2c1hA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		5 / 12 ALA A  66
GLU A  69
LEU A  40
ILE A  86
GLY A  85
 None
 1.04A 5gtrA-2c1hA:
undetectable		 5gtrA-2c1hA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		3 / 3 ILE A 180
MET A 251
ASP A 171
 None
 0.71A 5h2uA-2c1hA:
undetectable		 5h2uA-2c1hA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		5 / 8 ILE A  81
VAL A  37
VAL A 271
ILE A 243
ILE A 194
 None
 1.16A 5hi2A-2c1hA:
undetectable		 5hi2A-2c1hA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		4 / 5 ASP A 242
VAL A 149
GLY A 178
ALA A 179
 MG  A1329 ( 3.8A)
None
None
None
 1.06A 5hwaA-2c1hA:
undetectable		 5hwaA-2c1hA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		3 / 3 ALA A  21
ASN A  24
LEU A  25
 None
 0.46A 5i1nC-2c1hA:
undetectable		 5i1nC-2c1hA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		3 / 3 ASP A 313
ASN A  29
PHE A 269
 None
 0.74A 5jglB-2c1hA:
undetectable		 5jglB-2c1hA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		3 / 3 VAL A 149
GLU A 186
GLU A 182
 None
 0.95A 5jsdB-2c1hA:
undetectable
5jsdC-2c1hA:
undetectable		 5jsdB-2c1hA:
19.02
5jsdC-2c1hA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		4 / 7 SER A 158
ILE A 103
GLU A  96
ASP A 100
 None
 1.05A 5n5dA-2c1hA:
2.2		 5n5dA-2c1hA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Prosthecochloris
vibrioformis) 		5 / 12 GLY A 175
GLY A 178
ASP A 270
VAL A 271
ASP A 242
 None
None
None
None
MG  A1329 ( 3.8A)
 0.98A 5wz1A-2c1hA:
undetectable		 5wz1A-2c1hA:
23.05