SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c1l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2c1l RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		4 / 8 ASP A 209
ILE A 202
GLY A 343
GLY A 339
 None
 0.68A 1me7A-2c1lA:
undetectable		 1me7A-2c1lA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 2c1l RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		4 / 7 ALA A  69
TYR A 253
TYR A  47
PHE A 126
 None
 0.98A 2ajvH-2c1lA:
undetectable
2ajvL-2c1lA:
undetectable		 2ajvH-2c1lA:
20.71
2ajvL-2c1lA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 2c1l RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		4 / 7 LEU A  71
LEU A 161
TYR A 109
MET A 160
 None
 1.15A 2w8yA-2c1lA:
undetectable		 2w8yA-2c1lA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2c1l RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		4 / 8 ARG A 341
LEU A 205
LEU A 201
ILE A 316
 None
 0.72A 3ln1A-2c1lA:
undetectable		 3ln1A-2c1lA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2c1l RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		4 / 7 ARG A 341
LEU A 205
LEU A 201
ILE A 316
 None
 0.69A 3ln1B-2c1lA:
undetectable		 3ln1B-2c1lA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 2c1l RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		5 / 12 LEU A 285
ILE A 304
ALA A 303
ILE A 213
LEU A 205
 None
 1.03A 3vrmA-2c1lA:
undetectable		 3vrmA-2c1lA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2c1l RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		3 / 3 ASN A  46
LEU A  40
PHE A  44
 None
None
TLA  A1363 (-4.1A)
 0.64A 4dajB-2c1lA:
undetectable		 4dajB-2c1lA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2c1l RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		4 / 8 ASN A 260
TYR A 312
GLU A 313
TYR A 330
 None
 1.18A 4mj8A-2c1lA:
undetectable
4mj8C-2c1lA:
undetectable		 4mj8A-2c1lA:
18.28
4mj8C-2c1lA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 2c1l RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		5 / 12 THR A 171
GLY A  92
ILE A  68
HIS A  96
ASN A 172
 None
 1.25A 4pooB-2c1lA:
3.6		 4pooB-2c1lA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 2c1l RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		5 / 12 ILE A 301
THR A 287
LEU A 205
TRP A 229
LEU A 230
 None
 1.30A 4qynB-2c1lA:
undetectable		 4qynB-2c1lA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2c1l RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		5 / 12 ILE A 301
THR A 287
LEU A 205
TRP A 229
LEU A 230
 None
 1.32A 4qzuA-2c1lA:
undetectable		 4qzuA-2c1lA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2c1l RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		4 / 6 ASN A 347
GLU A 197
TYR A 312
PHE A 237
 None
 1.41A 4twdG-2c1lA:
undetectable
4twdH-2c1lA:
undetectable		 4twdG-2c1lA:
22.22
4twdH-2c1lA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2c1l RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		5 / 12 VAL A  84
TRP A 153
VAL A  67
ALA A  69
LEU A  71
 None
 1.05A 5iktA-2c1lA:
undetectable		 5iktA-2c1lA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 2c1l RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		5 / 12 GLY A 130
GLY A 110
VAL A 120
GLY A  50
GLY A  49
 TLA  A1363 ( 4.5A)
None
None
None
None
 0.84A 5koxA-2c1lA:
undetectable		 5koxA-2c1lA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 2c1l RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		4 / 7 ASP A 142
PHE A   3
SER A  29
ASN A  30
 None
 1.08A 5l1fC-2c1lA:
undetectable		 5l1fC-2c1lA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 2c1l RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		4 / 7 GLY A  18
PHE A   4
SER A 122
ASN A   9
 None
 1.08A 5n5dB-2c1lA:
2.5		 5n5dB-2c1lA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 2c1l RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		4 / 4 LEU A  71
MET A 170
ILE A 103
LEU A 182
 None
 1.37A 5nfpA-2c1lA:
undetectable		 5nfpA-2c1lA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 2c1l RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		5 / 12 LEU A  19
GLY A  49
GLY A 128
ASN A   9
PRO A   8
 None
 1.05A 6ce2B-2c1lA:
undetectable		 6ce2B-2c1lA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 2c1l RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		5 / 12 VAL A  67
GLY A  50
LEU A  38
VAL A  95
VAL A  93
 None
 0.90A 6dh0B-2c1lA:
undetectable		 6dh0B-2c1lA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 2c1l RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		5 / 12 ILE A 304
PHE A 237
PHE A 342
ASP A 236
ILE A 257
 None
 1.47A 6dwnB-2c1lA:
undetectable		 6dwnB-2c1lA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB7_A_PARA900_0
(AAC(3)-IIIB PROTEIN)		 2c1l RESTRICTION
ENDONUCLEASE
(Bacillus
firmus) 		5 / 10 ASN A 143
TYR A  39
THR A  37
GLY A  36
GLU A  35
 None
 1.17A 6mb7A-2c1lA:
0.0		 6mb7A-2c1lA:
14.29