SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c1u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 2c1u DI-HAEM CYTOCHROME C
PEROXIDASE
(Paracoccus
pantotrophus) 		4 / 4 GLY A 121
VAL A 123
TRP A  87
GLY A 126
 None
HEC  A 401 (-4.6A)
None
None
 1.35A 1ng8A-2c1uA:
undetectable		 1ng8A-2c1uA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 2c1u DI-HAEM CYTOCHROME C
PEROXIDASE
(Paracoccus
pantotrophus) 		4 / 4 GLY A 121
VAL A 123
TRP A  87
GLY A 126
 None
HEC  A 401 (-4.6A)
None
None
 1.35A 1ng8B-2c1uA:
undetectable		 1ng8B-2c1uA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 2c1u DI-HAEM CYTOCHROME C
PEROXIDASE
(Paracoccus
pantotrophus) 		3 / 3 ASP A 185
LEU A 188
HIS A 215
 None
None
HEC  A 402 (-3.2A)
 0.62A 1qknA-2c1uA:
undetectable		 1qknA-2c1uA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 2c1u DI-HAEM CYTOCHROME C
PEROXIDASE
(Paracoccus
pantotrophus) 		4 / 5 ILE A  63
SER A  64
PRO A  55
PHE A  53
 HEC  A 401 (-4.6A)
None
None
None
 1.35A 3bjwC-2c1uA:
undetectable		 3bjwC-2c1uA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 2c1u DI-HAEM CYTOCHROME C
PEROXIDASE
(Paracoccus
pantotrophus) 		3 / 3 PHE A 228
SER A 291
GLN A 293
 HEC  A 402 (-4.5A)
None
None
 0.78A 3smtA-2c1uA:
undetectable		 3smtA-2c1uA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 2c1u DI-HAEM CYTOCHROME C
PEROXIDASE
(Paracoccus
pantotrophus) 		3 / 3 PHE A 274
VAL A 279
GLU A 284
 HEC  A 402 (-4.3A)
None
None
 0.84A 4fvqA-2c1uA:
undetectable		 4fvqA-2c1uA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 2c1u DI-HAEM CYTOCHROME C
PEROXIDASE
(Paracoccus
pantotrophus) 		5 / 12 LEU A 264
VAL A 286
GLY A 245
PHE A 274
THR A 244
 HEC  A 402 (-4.8A)
HEC  A 402 ( 4.2A)
None
HEC  A 402 (-4.3A)
None
 1.36A 4mubA-2c1uA:
undetectable		 4mubA-2c1uA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 2c1u DI-HAEM CYTOCHROME C
PEROXIDASE
(Paracoccus
pantotrophus) 		5 / 12 ASN A 103
LEU A 313
ARG A 265
ILE A  21
THR A 179
 HEC  A 401 (-4.0A)
None
None
None
None
 1.29A 4o5fA-2c1uA:
undetectable
4o5fB-2c1uA:
undetectable		 4o5fA-2c1uA:
22.97
4o5fB-2c1uA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 2c1u DI-HAEM CYTOCHROME C
PEROXIDASE
(Paracoccus
pantotrophus) 		3 / 3 MET A 195
GLU A 199
LEU A 203
 None
 0.45A 4v2oB-2c1uA:
0.0		 4v2oB-2c1uA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2c1u DI-HAEM CYTOCHROME C
PEROXIDASE
(Paracoccus
pantotrophus) 		5 / 11 ASN A   7
LEU A  10
GLU A 199
LYS A 200
LEU A 203
 None
 0.74A 4wg0B-2c1uA:
undetectable
4wg0C-2c1uA:
undetectable
4wg0D-2c1uA:
undetectable		 4wg0B-2c1uA:
3.59
4wg0C-2c1uA:
3.59
4wg0D-2c1uA:
3.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2c1u DI-HAEM CYTOCHROME C
PEROXIDASE
(Paracoccus
pantotrophus) 		5 / 7 GLU A 199
LYS A 200
LEU A 203
ASN A   7
LEU A  10
 None
 0.71A 4wg0B-2c1uA:
undetectable
4wg0C-2c1uA:
undetectable		 4wg0B-2c1uA:
3.59
4wg0C-2c1uA:
3.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2c1u DI-HAEM CYTOCHROME C
PEROXIDASE
(Paracoccus
pantotrophus) 		5 / 11 ASN A   7
LEU A  10
GLU A 199
LYS A 200
LEU A 203
 None
 0.74A 4wg0D-2c1uA:
undetectable
4wg0E-2c1uA:
undetectable
4wg0F-2c1uA:
undetectable		 4wg0D-2c1uA:
3.59
4wg0E-2c1uA:
3.59
4wg0F-2c1uA:
3.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2c1u DI-HAEM CYTOCHROME C
PEROXIDASE
(Paracoccus
pantotrophus) 		5 / 11 GLU A 199
LYS A 200
LEU A 203
ASN A   7
LEU A  10
 None
 0.62A 4wg0C-2c1uA:
undetectable
4wg0D-2c1uA:
undetectable
4wg0E-2c1uA:
undetectable		 4wg0C-2c1uA:
3.59
4wg0D-2c1uA:
3.59
4wg0E-2c1uA:
3.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2c1u DI-HAEM CYTOCHROME C
PEROXIDASE
(Paracoccus
pantotrophus) 		5 / 11 ASN A   7
LEU A  10
GLU A 199
LYS A 200
LEU A 203
 None
 0.68A 4wg0F-2c1uA:
undetectable
4wg0G-2c1uA:
undetectable
4wg0H-2c1uA:
undetectable		 4wg0F-2c1uA:
3.59
4wg0G-2c1uA:
3.59
4wg0H-2c1uA:
3.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2c1u DI-HAEM CYTOCHROME C
PEROXIDASE
(Paracoccus
pantotrophus) 		5 / 11 GLU A 199
LYS A 200
LEU A 203
ASN A   7
LEU A  10
 None
 0.63A 4wg0E-2c1uA:
undetectable
4wg0F-2c1uA:
undetectable
4wg0G-2c1uA:
undetectable		 4wg0E-2c1uA:
3.59
4wg0F-2c1uA:
3.59
4wg0G-2c1uA:
3.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2c1u DI-HAEM CYTOCHROME C
PEROXIDASE
(Paracoccus
pantotrophus) 		5 / 11 GLU A 199
LYS A 200
LEU A 203
ASN A   7
LEU A  10
 None
 0.60A 4wg0G-2c1uA:
undetectable
4wg0H-2c1uA:
undetectable
4wg0I-2c1uA:
undetectable		 4wg0G-2c1uA:
3.59
4wg0H-2c1uA:
3.59
4wg0I-2c1uA:
3.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2c1u DI-HAEM CYTOCHROME C
PEROXIDASE
(Paracoccus
pantotrophus) 		5 / 11 ASN A   7
LEU A  10
GLU A 199
LYS A 200
LEU A 203
 None
 0.78A 4wg0J-2c1uA:
undetectable
4wg0K-2c1uA:
undetectable
4wg0L-2c1uA:
undetectable		 4wg0J-2c1uA:
3.59
4wg0K-2c1uA:
3.59
4wg0L-2c1uA:
3.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2c1u DI-HAEM CYTOCHROME C
PEROXIDASE
(Paracoccus
pantotrophus) 		5 / 11 GLU A 199
LYS A 200
LEU A 203
ASN A   7
LEU A  10
 None
 0.82A 4wg0I-2c1uA:
undetectable
4wg0J-2c1uA:
undetectable
4wg0K-2c1uA:
undetectable		 4wg0I-2c1uA:
3.59
4wg0J-2c1uA:
3.59
4wg0K-2c1uA:
3.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2c1u DI-HAEM CYTOCHROME C
PEROXIDASE
(Paracoccus
pantotrophus) 		5 / 7 ASN A   7
LEU A  10
GLU A 199
LYS A 200
LEU A 203
 None
 0.65A 4wg0L-2c1uA:
undetectable
4wg0M-2c1uA:
undetectable		 4wg0L-2c1uA:
3.59
4wg0M-2c1uA:
3.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2c1u DI-HAEM CYTOCHROME C
PEROXIDASE
(Paracoccus
pantotrophus) 		5 / 11 GLU A 199
LYS A 200
LEU A 203
ASN A   7
LEU A  10
 None
 0.79A 4wg0K-2c1uA:
undetectable
4wg0L-2c1uA:
undetectable
4wg0M-2c1uA:
undetectable		 4wg0K-2c1uA:
3.59
4wg0L-2c1uA:
3.59
4wg0M-2c1uA:
3.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2c1u DI-HAEM CYTOCHROME C
PEROXIDASE
(Paracoccus
pantotrophus) 		3 / 3 GLY A 222
THR A  81
PRO A  95
 None
None
HEC  A 401 (-4.3A)
 0.64A 5v5zA-2c1uA:
undetectable		 5v5zA-2c1uA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2c1u DI-HAEM CYTOCHROME C
PEROXIDASE
(Paracoccus
pantotrophus) 		3 / 3 ARG A  56
PHE A  52
LEU A 325
 None
 0.89A 5x1bC-2c1uA:
undetectable		 5x1bC-2c1uA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 2c1u DI-HAEM CYTOCHROME C
PEROXIDASE
(Paracoccus
pantotrophus) 		4 / 7 ARG A 186
GLU A  23
THR A 179
PRO A  22
 None
 1.41A 6a4iB-2c1uA:
undetectable		 6a4iB-2c1uA:
19.52