SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c1w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 2c1w ENDOU PROTEIN
(Xenopus
laevis) 		5 / 11 ASP A 210
GLY A 232
TYR A  33
GLU A 238
PHE A  60
 None
 1.32A 1w76A-2c1wA:
undetectable		 1w76A-2c1wA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 2c1w ENDOU PROTEIN
(Xenopus
laevis) 		4 / 7 HIS A 272
ASP A 156
THR A 278
GLY A 277
 PO4  A1290 (-3.8A)
None
PO4  A1290 (-3.9A)
PO4  A1290 ( 3.8A)
 1.04A 2f6dA-2c1wA:
undetectable		 2f6dA-2c1wA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 2c1w ENDOU PROTEIN
(Xenopus
laevis) 		5 / 12 VAL A 114
ALA A 118
GLU A 238
MET A 115
THR A 112
 None
 1.30A 3dl9B-2c1wA:
undetectable		 3dl9B-2c1wA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2c1w ENDOU PROTEIN
(Xenopus
laevis) 		4 / 8 PHE A 246
GLU A 251
SER A 254
VAL A 269
 None
 1.37A 3jx1A-2c1wA:
undetectable
3jx1B-2c1wA:
undetectable		 3jx1A-2c1wA:
20.72
3jx1B-2c1wA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2c1w ENDOU PROTEIN
(Xenopus
laevis) 		4 / 8 PHE A 246
GLU A 251
SER A 254
VAL A 269
 None
 1.36A 3nlyA-2c1wA:
undetectable
3nlyB-2c1wA:
undetectable		 3nlyA-2c1wA:
20.72
3nlyB-2c1wA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2c1w ENDOU PROTEIN
(Xenopus
laevis) 		4 / 8 PHE A 246
GLU A 251
SER A 254
VAL A 269
 None
 1.36A 3rqlA-2c1wA:
undetectable
3rqlB-2c1wA:
undetectable		 3rqlA-2c1wA:
20.72
3rqlB-2c1wA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2c1w ENDOU PROTEIN
(Xenopus
laevis) 		4 / 8 PHE A 246
GLU A 251
SER A 254
VAL A 269
 None
 1.38A 4capA-2c1wA:
undetectable
4capB-2c1wA:
undetectable		 4capA-2c1wA:
20.72
4capB-2c1wA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2c1w ENDOU PROTEIN
(Xenopus
laevis) 		4 / 8 PHE A 246
GLU A 251
SER A 254
VAL A 269
 None
 1.36A 4d32A-2c1wA:
undetectable
4d32B-2c1wA:
undetectable		 4d32A-2c1wA:
20.72
4d32B-2c1wA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2c1w ENDOU PROTEIN
(Xenopus
laevis) 		5 / 12 ALA A 240
LEU A 122
LEU A  15
LYS A  14
SER A  13
 None
 1.18A 4q0dA-2c1wA:
undetectable		 4q0dA-2c1wA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2c1w ENDOU PROTEIN
(Xenopus
laevis) 		5 / 12 ALA A 240
LEU A 122
LEU A  15
LYS A  14
SER A  13
 None
 1.17A 4q0dB-2c1wA:
undetectable		 4q0dB-2c1wA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2c1w ENDOU PROTEIN
(Xenopus
laevis) 		5 / 12 ALA A 240
LEU A 122
LEU A  15
LYS A  14
SER A  13
 None
 1.17A 4q0dC-2c1wA:
undetectable		 4q0dC-2c1wA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2c1w ENDOU PROTEIN
(Xenopus
laevis) 		5 / 12 ALA A 240
LEU A 122
LEU A  15
LYS A  14
SER A  13
 None
 1.17A 4q0dD-2c1wA:
undetectable		 4q0dD-2c1wA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2c1w ENDOU PROTEIN
(Xenopus
laevis) 		5 / 12 ALA A 240
LEU A 122
LEU A  15
LYS A  14
SER A  13
 None
 1.17A 4q0dE-2c1wA:
undetectable		 4q0dE-2c1wA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2c1w ENDOU PROTEIN
(Xenopus
laevis) 		4 / 8 PHE A 246
GLU A 251
SER A 254
VAL A 269
 None
 1.38A 4v3yA-2c1wA:
undetectable
4v3yB-2c1wA:
undetectable		 4v3yA-2c1wA:
20.72
4v3yB-2c1wA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2c1w ENDOU PROTEIN
(Xenopus
laevis) 		4 / 5 SER A 157
ARG A 271
GLY A 273
ARG A 149
 None
None
None
PO4  A1290 (-3.5A)
 1.16A 5cdqR-2c1wA:
undetectable
5cdqS-2c1wA:
undetectable
5cdqT-2c1wA:
undetectable		 5cdqR-2c1wA:
20.84
5cdqS-2c1wA:
21.21
5cdqT-2c1wA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2c1w ENDOU PROTEIN
(Xenopus
laevis) 		4 / 5 TYR A  43
GLY A  42
GLY A 232
LEU A  37
 None
 0.80A 5jlcA-2c1wA:
undetectable		 5jlcA-2c1wA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 2c1w ENDOU PROTEIN
(Xenopus
laevis) 		3 / 3 TYR A  33
TYR A 263
GLN A 211
 None
 1.12A 5jsdA-2c1wA:
undetectable
5jsdB-2c1wA:
undetectable		 5jsdA-2c1wA:
16.99
5jsdB-2c1wA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 2c1w ENDOU PROTEIN
(Xenopus
laevis) 		3 / 3 TYR A  33
TYR A 263
GLN A 211
 None
 1.11A 5jsdB-2c1wA:
undetectable
5jsdC-2c1wA:
undetectable		 5jsdB-2c1wA:
16.99
5jsdC-2c1wA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 2c1w ENDOU PROTEIN
(Xenopus
laevis) 		4 / 7 HIS A 272
ASN A 270
HIS A 162
SER A 168
 PO4  A1290 (-3.8A)
PO4  A1290 (-4.3A)
PO4  A1290 (-3.7A)
None
 1.06A 5m8rA-2c1wA:
undetectable		 5m8rA-2c1wA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 2c1w ENDOU PROTEIN
(Xenopus
laevis) 		4 / 5 THR A  76
GLU A 236
HIS A 119
LEU A 139
 None
 1.25A 5utuH-2c1wA:
undetectable		 5utuH-2c1wA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA806_0
(GEPHYRIN)		 2c1w ENDOU PROTEIN
(Xenopus
laevis) 		4 / 4 MET A 175
GLY A 176
HIS A 178
GLY A 166
 None
 1.36A 6fgdA-2c1wA:
undetectable		 6fgdA-2c1wA:
19.82