SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c1z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		4 / 6 ASN A 354
ILE A 219
SER A 146
ASN A 378
 U2F  A1457 (-3.8A)
None
KMP  A1456 (-4.1A)
None
 1.20A 1h7xB-2c1zA:
3.9		 1h7xB-2c1zA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		5 / 9 GLY A 363
GLY A 415
ILE A 409
VAL A 382
ILE A 388
 None
 1.03A 1hxwA-2c1zA:
undetectable		 1hxwA-2c1zA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		4 / 8 SER A 439
PHE A 222
LEU A 425
LEU A 356
 None
 0.94A 2bfpB-2c1zA:
5.1		 2bfpB-2c1zA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		4 / 8 SER A 439
PHE A 222
LEU A 425
LEU A 356
 None
 0.93A 2bfpC-2c1zA:
7.4		 2bfpC-2c1zA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		4 / 5 PHE A 121
THR A 141
LEU A 147
ALA A 120
 KMP  A1456 (-4.5A)
U2F  A1457 (-3.9A)
None
None
 1.36A 2e1qD-2c1zA:
undetectable		 2e1qD-2c1zA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_D_TPFD2473_1
(CYTOCHROME P450 121)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		5 / 10 VAL A  27
PHE A  42
ALA A  21
SER A  44
PHE A  98
 None
 1.23A 2ij7D-2c1zA:
0.0		 2ij7D-2c1zA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		3 / 3 TRP A 264
VAL A 364
ARG A 426
 None
 0.96A 3b0wA-2c1zA:
undetectable		 3b0wA-2c1zA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		5 / 11 VAL A 210
LEU A 211
GLY A 208
ILE A 153
SER A 201
 None
 1.01A 3bjwE-2c1zA:
undetectable		 3bjwE-2c1zA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		3 / 3 ASN A 145
ASP A 374
ARG A  30
 None
U2F  A1457 (-2.7A)
None
 0.85A 3k13C-2c1zA:
undetectable		 3k13C-2c1zA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		4 / 7 ILE A 276
VAL A 289
LEU A 292
SER A 293
 None
 0.71A 3r9vA-2c1zA:
undetectable
3r9vB-2c1zA:
0.0		 3r9vA-2c1zA:
22.61
3r9vB-2c1zA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		4 / 7 LYS A 436
ARG A 431
GLY A 434
PRO A 435
 None
 1.40A 3ucbB-2c1zA:
undetectable		 3ucbB-2c1zA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		4 / 5 ARG A 312
VAL A 289
LEU A 292
SER A 293
 None
 1.16A 4e1gA-2c1zA:
undetectable		 4e1gA-2c1zA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		4 / 7 PRO A 138
GLY A 208
ALA A 125
GLN A 188
 None
None
None
KMP  A1456 (-4.2A)
 0.74A 4g0uB-2c1zA:
2.2		 4g0uB-2c1zA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		4 / 6 PRO A 138
GLY A 208
ALA A 125
GLN A 188
 None
None
None
KMP  A1456 (-4.2A)
 0.85A 4g0uA-2c1zA:
2.0		 4g0uA-2c1zA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		4 / 6 THR A 230
VAL A 382
SER A 221
ASP A 186
 None
 0.96A 4iaqA-2c1zA:
undetectable		 4iaqA-2c1zA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		4 / 6 ILE A  87
PHE A  90
THR A 141
TRP A 140
 None
None
U2F  A1457 (-3.9A)
None
 1.21A 5g08A-2c1zA:
undetectable		 5g08A-2c1zA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		5 / 12 ASP A 407
ALA A 346
ARG A 391
ARG A 419
LEU A 418
 None
 1.22A 5nd7B-2c1zA:
5.8		 5nd7B-2c1zA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE
(Vitis
vinifera) 		3 / 3 LEU A 377
GLY A 143
PHE A 121
 None
None
KMP  A1456 (-4.5A)
 0.58A 6exiC-2c1zA:
5.7		 6exiC-2c1zA:
10.37