SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c20'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		4 / 8 VAL A  82
SER A  83
ASN A 140
LYS A 146
 None
None
None
NAD  A 401 (-2.0A)
 1.21A 1hwiB-2c20A:
undetectable		 1hwiB-2c20A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		4 / 7 VAL A  82
SER A  83
ASN A 140
LYS A 146
 None
None
None
NAD  A 401 (-2.0A)
 1.22A 1hwiC-2c20A:
undetectable		 1hwiC-2c20A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		4 / 7 VAL A  82
SER A  83
ASN A 140
LYS A 146
 None
None
None
NAD  A 401 (-2.0A)
 1.22A 1hwiD-2c20A:
undetectable		 1hwiD-2c20A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		4 / 8 VAL A  82
SER A  83
ASN A 140
LYS A 146
 None
None
None
NAD  A 401 (-2.0A)
 1.20A 1hwkA-2c20A:
undetectable		 1hwkA-2c20A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		4 / 8 VAL A  82
SER A  83
ASN A 140
LYS A 146
 None
None
None
NAD  A 401 (-2.0A)
 1.20A 1hwkC-2c20A:
undetectable		 1hwkC-2c20A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		4 / 8 VAL A  82
SER A  83
ASN A 140
LYS A 146
 None
None
None
NAD  A 401 (-2.0A)
 1.20A 1hwkD-2c20A:
undetectable		 1hwkD-2c20A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		3 / 3 VAL A  18
ALA A  17
HIS A 234
 None
 0.59A 1q23C-2c20A:
undetectable		 1q23C-2c20A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		3 / 3 VAL A  18
ALA A  17
HIS A 234
 None
 0.55A 1q23H-2c20A:
undetectable		 1q23H-2c20A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		3 / 3 VAL A  18
ALA A  17
HIS A 234
 None
 0.69A 1q23G-2c20A:
undetectable		 1q23G-2c20A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		3 / 3 VAL A  18
ALA A  17
HIS A 234
 None
 0.65A 1q23L-2c20A:
undetectable		 1q23L-2c20A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		3 / 3 VAL A  18
ALA A  17
HIS A 234
 None
 0.56A 1q23J-2c20A:
undetectable		 1q23J-2c20A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		4 / 7 ASN A  94
HIS A  73
PHE A 115
TYR A 142
 None
 1.14A 1tdnA-2c20A:
3.5		 1tdnA-2c20A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		4 / 5 TRP A 303
PRO A 305
GLY A 253
GLY A 255
 None
 1.04A 1zlqA-2c20A:
0.0		 1zlqA-2c20A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		5 / 12 ILE A 192
LEU A 194
ALA A 173
GLU A 183
LEU A  79
 None
None
None
ZN  A 601 (-2.9A)
None
 1.26A 2a58A-2c20A:
2.8
2a58B-2c20A:
2.6		 2a58A-2c20A:
22.58
2a58B-2c20A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		5 / 12 ILE A 192
LEU A 194
ALA A 173
GLU A 183
LEU A  79
 None
None
None
ZN  A 601 (-2.9A)
None
 1.27A 2a58D-2c20A:
undetectable
2a58E-2c20A:
2.9		 2a58D-2c20A:
22.58
2a58E-2c20A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		4 / 7 ARG A 186
TRP A 320
GLU A 183
ALA A  41
 None
None
ZN  A 601 (-2.9A)
None
 0.97A 2ejfA-2c20A:
undetectable		 2ejfA-2c20A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		5 / 8 LEU A 101
ALA A  75
GLY A   9
ILE A   6
LEU A  59
 None
NAD  A 401 (-3.7A)
None
None
None
 1.12A 2o4nB-2c20A:
undetectable		 2o4nB-2c20A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		3 / 3 ASN A 256
ARG A 289
ASP A 217
 None
 0.95A 2qe6A-2c20A:
4.7		 2qe6A-2c20A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		3 / 3 ASN A 256
ARG A 289
ASP A 217
 None
 0.89A 2qe6B-2c20A:
4.6		 2qe6B-2c20A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		5 / 7 GLY A   9
ASP A  32
ASP A  52
LEU A  53
ARG A  54
 None
NAD  A 401 (-2.7A)
NAD  A 401 (-3.1A)
NAD  A 401 (-4.1A)
NAD  A 401 ( 4.6A)
 1.26A 2uyqA-2c20A:
4.4		 2uyqA-2c20A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		3 / 3 MET A  72
MET A 152
PHE A 167
 None
 1.19A 3gn8A-2c20A:
undetectable		 3gn8A-2c20A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		4 / 5 ARG A 168
THR A 136
GLU A 144
GLU A 150
 None
 1.26A 3ny4A-2c20A:
undetectable		 3ny4A-2c20A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		5 / 11 SER A  15
ILE A  13
VAL A 227
VAL A 172
HIS A 321
 None
NAD  A 401 (-3.8A)
None
NAD  A 401 (-3.9A)
None
 1.27A 3rf4A-2c20A:
undetectable
3rf4C-2c20A:
undetectable		 3rf4A-2c20A:
14.83
3rf4C-2c20A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		5 / 11 HIS A 321
SER A  15
ILE A  13
VAL A 227
VAL A 172
 None
None
NAD  A 401 (-3.8A)
None
NAD  A 401 (-3.9A)
 1.27A 3rf4A-2c20A:
undetectable
3rf4B-2c20A:
undetectable		 3rf4A-2c20A:
14.83
3rf4B-2c20A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		4 / 8 PHE A  63
LEU A   5
LEU A  59
PHE A  58
 None
 0.93A 4qopC-2c20A:
undetectable		 4qopC-2c20A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		4 / 8 ILE A 114
VAL A 227
LEU A 230
PHE A 167
 None
 0.94A 4r38B-2c20A:
undetectable		 4r38B-2c20A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		4 / 7 GLU A 144
ALA A 120
GLY A 123
TYR A 122
 None
 0.92A 5uxdA-2c20A:
undetectable		 5uxdA-2c20A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 2c20 UDP-GLUCOSE
4-EPIMERASE
(Bacillus
anthracis) 		3 / 3 ALA A 119
VAL A  80
TYR A 142
 None
 0.41A 5zmqH-2c20A:
undetectable		 5zmqH-2c20A:
24.26