SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c27'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 2c27 MYCOTHIOL SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 GLY A 250
LEU A 253
THR A 254
VAL A 240
 COA  A1314 (-3.3A)
None
None
COA  A1314 (-4.0A)
 0.93A 1ekjF-2c27A:
undetectable
1ekjG-2c27A:
undetectable		 1ekjF-2c27A:
22.86
1ekjG-2c27A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2c27 MYCOTHIOL SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 297
VAL A 235
LEU A 238
ALA A 290
 None
None
COA  A1314 (-4.5A)
COA  A1314 (-3.6A)
 0.95A 1fiqC-2c27A:
undetectable		 1fiqC-2c27A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 2c27 MYCOTHIOL SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 124
LEU A 125
ARG A  97
LEU A  80
ALA A  94
 ACO  A1313 ( 3.8A)
None
None
ACO  A1313 (-4.2A)
None
 1.02A 1h9zA-2c27A:
undetectable		 1h9zA-2c27A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 2c27 MYCOTHIOL SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 124
LEU A 125
ARG A  97
LEU A  80
ALA A  94
 ACO  A1313 ( 3.8A)
None
None
ACO  A1313 (-4.2A)
None
 1.04A 1ha2A-2c27A:
undetectable		 1ha2A-2c27A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 2c27 MYCOTHIOL SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 TYR A 282
VAL A  31
ARG A 131
TRP A 110
 MA8  A1312 (-4.4A)
None
None
MA8  A1312 (-3.9A)
 1.24A 1s3zA-2c27A:
11.3
1s3zB-2c27A:
11.5		 1s3zA-2c27A:
19.55
1s3zB-2c27A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2c27 MYCOTHIOL SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 244
LEU A 218
VAL A 169
ARG A 168
LEU A 238
 None
None
None
None
COA  A1314 (-4.5A)
 1.17A 1s9pB-2c27A:
undetectable		 1s9pB-2c27A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 2c27 MYCOTHIOL SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 127
THR A 121
LEU A  65
LEU A  80
GLY A  92
 None
ACO  A1313 (-3.6A)
None
ACO  A1313 (-4.2A)
ACO  A1313 (-3.4A)
 1.06A 1xwfA-2c27A:
undetectable		 1xwfA-2c27A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_1
(ADENOSYLHOMOCYSTEINA
SE)		 2c27 MYCOTHIOL SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 127
THR A 121
LEU A  65
LEU A  80
GLY A  92
 None
ACO  A1313 (-3.6A)
None
ACO  A1313 (-4.2A)
ACO  A1313 (-3.4A)
 1.04A 1xwfB-2c27A:
undetectable		 1xwfB-2c27A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_1
(ADENOSYLHOMOCYSTEINA
SE)		 2c27 MYCOTHIOL SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 127
THR A 121
LEU A  65
LEU A  80
GLY A  92
 None
ACO  A1313 (-3.6A)
None
ACO  A1313 (-4.2A)
ACO  A1313 (-3.4A)
 1.07A 1xwfC-2c27A:
undetectable		 1xwfC-2c27A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_1
(ADENOSYLHOMOCYSTEINA
SE)		 2c27 MYCOTHIOL SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 127
THR A 121
LEU A  65
LEU A  80
GLY A  92
 None
ACO  A1313 (-3.6A)
None
ACO  A1313 (-4.2A)
ACO  A1313 (-3.4A)
 1.05A 1xwfD-2c27A:
undetectable		 1xwfD-2c27A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2c27 MYCOTHIOL SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 204
ASN A 171
GLN A 245
PHE A 206
 None
None
COA  A1314 (-3.5A)
None
 1.17A 2jn3A-2c27A:
undetectable		 2jn3A-2c27A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 2c27 MYCOTHIOL SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 GLU A  79
ASP A 305
TYR A 282
 MA8  A1312 ( 4.9A)
None
MA8  A1312 (-4.4A)
 0.85A 2yvlB-2c27A:
2.7		 2yvlB-2c27A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2c27 MYCOTHIOL SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 163
LEU A 167
GLN A 180
 None
 0.72A 3g4lA-2c27A:
undetectable		 3g4lA-2c27A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 2c27 MYCOTHIOL SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 239
GLY A 219
LEU A 238
LEU A 249
ALA A 173
 COA  A1314 (-3.5A)
None
COA  A1314 (-4.5A)
COA  A1314 (-4.9A)
COA  A1314 (-4.1A)
 1.05A 3kkzA-2c27A:
undetectable		 3kkzA-2c27A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 2c27 MYCOTHIOL SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 235
GLY A 257
ILE A 256
VAL A 240
 None
None
None
COA  A1314 (-4.0A)
 0.82A 3ufnB-2c27A:
undetectable		 3ufnB-2c27A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 2c27 MYCOTHIOL SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 222
ARG A 191
LEU A 167
 None
 0.91A 5dbyA-2c27A:
undetectable		 5dbyA-2c27A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 2c27 MYCOTHIOL SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 9 LEU A 238
LEU A 249
GLY A 250
LEU A 253
ALA A 205
 COA  A1314 (-4.5A)
COA  A1314 (-4.9A)
COA  A1314 (-3.3A)
None
None
 0.99A 5dqfA-2c27A:
undetectable		 5dqfA-2c27A:
18.63