SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c2g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 2c2g THREONINE SYNTHASE
(Arabidopsis
thaliana) 		4 / 8 VAL A 107
ALA A 274
PHE A 162
GLU A 128
 None
 1.08A 1dmiA-2c2gA:
undetectable
1dmiB-2c2gA:
undetectable		 1dmiA-2c2gA:
23.03
1dmiB-2c2gA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 2c2g THREONINE SYNTHASE
(Arabidopsis
thaliana) 		4 / 7 ILE A 401
PHE A 139
PHE A 143
PHE A 457
 None
 1.12A 1e72M-2c2gA:
undetectable		 1e72M-2c2gA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 2c2g THREONINE SYNTHASE
(Arabidopsis
thaliana) 		4 / 7 TRP A 108
LEU A 268
GLY A 270
LEU A 115
 None
 0.96A 1gtiD-2c2gA:
undetectable		 1gtiD-2c2gA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2c2g THREONINE SYNTHASE
(Arabidopsis
thaliana) 		5 / 12 LEU A 415
LEU A 412
LEU A 409
ALA A 408
ILE A 378
 None
 1.02A 1s9pC-2c2gA:
undetectable		 1s9pC-2c2gA:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C2B_A_SAMA500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 2c2g THREONINE SYNTHASE
(Arabidopsis
thaliana) 		5 / 10 SER A  99
TRP A 101
GLY A 104
SER A 105
SER A 125
 None
 0.51A 2c2bA-2c2gA:
56.4
2c2bB-2c2gA:
60.5		 2c2bA-2c2gA:
100.00
2c2bB-2c2gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C2B_B_SAMB500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 2c2g THREONINE SYNTHASE
(Arabidopsis
thaliana) 		5 / 10 SER A  99
TRP A 101
GLY A 104
SER A 105
SER A 125
 None
 0.48A 2c2bA-2c2gA:
56.4
2c2bB-2c2gA:
60.5		 2c2bA-2c2gA:
100.00
2c2bB-2c2gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C2B_C_SAMC500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 2c2g THREONINE SYNTHASE
(Arabidopsis
thaliana) 		5 / 10 SER A  99
TRP A 101
GLY A 104
SER A 105
SER A 125
 None
 0.48A 2c2bC-2c2gA:
56.3
2c2bD-2c2gA:
60.5		 2c2bC-2c2gA:
100.00
2c2bD-2c2gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C2B_E_SAME500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 2c2g THREONINE SYNTHASE
(Arabidopsis
thaliana) 		5 / 11 SER A  99
TRP A 101
GLY A 104
SER A 105
SER A 125
 None
 0.49A 2c2bE-2c2gA:
60.2
2c2bF-2c2gA:
56.4		 2c2bE-2c2gA:
100.00
2c2bF-2c2gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C2B_F_SAMF500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 2c2g THREONINE SYNTHASE
(Arabidopsis
thaliana) 		5 / 10 SER A  99
TRP A 101
GLY A 104
SER A 105
SER A 125
 None
 0.50A 2c2bE-2c2gA:
60.2
2c2bF-2c2gA:
56.4		 2c2bE-2c2gA:
100.00
2c2bF-2c2gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 2c2g THREONINE SYNTHASE
(Arabidopsis
thaliana) 		5 / 10 ALA A 274
VAL A 290
VAL A 292
PRO A 293
VAL A 428
 None
 1.00A 2nnjA-2c2gA:
undetectable		 2nnjA-2c2gA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2c2g THREONINE SYNTHASE
(Arabidopsis
thaliana) 		5 / 12 HIS A 153
SER A 431
PHE A 134
THR A 405
LEU A 412
 None
 1.27A 2xrlA-2c2gA:
undetectable		 2xrlA-2c2gA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2c2g THREONINE SYNTHASE
(Arabidopsis
thaliana) 		4 / 7 TYR A 337
VAL A 323
CYH A 375
ILE A 300
 None
 1.32A 2xz5B-2c2gA:
undetectable
2xz5E-2c2gA:
undetectable		 2xz5B-2c2gA:
17.28
2xz5E-2c2gA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2c2g THREONINE SYNTHASE
(Arabidopsis
thaliana) 		4 / 7 ILE A 300
TYR A 337
VAL A 323
CYH A 375
 None
 1.35A 2xz5D-2c2gA:
undetectable
2xz5E-2c2gA:
undetectable		 2xz5D-2c2gA:
17.28
2xz5E-2c2gA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2c2g THREONINE SYNTHASE
(Arabidopsis
thaliana) 		4 / 7 THR A 397
GLY A 398
HIS A 153
ILE A 401
 None
 0.88A 2y7wC-2c2gA:
undetectable		 2y7wC-2c2gA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 2c2g THREONINE SYNTHASE
(Arabidopsis
thaliana) 		3 / 3 THR A 273
LYS A 437
GLU A 277
 None
 0.94A 3ijdB-2c2gA:
undetectable		 3ijdB-2c2gA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 2c2g THREONINE SYNTHASE
(Arabidopsis
thaliana) 		4 / 5 MET A 146
PHE A 143
PHE A 139
PHE A 413
 None
 1.37A 3ko0F-2c2gA:
undetectable
3ko0G-2c2gA:
0.0		 3ko0F-2c2gA:
11.97
3ko0G-2c2gA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 2c2g THREONINE SYNTHASE
(Arabidopsis
thaliana) 		4 / 5 SER A 364
ARG A 367
TYR A 301
VAL A 369
 None
 1.41A 3sufC-2c2gA:
undetectable		 3sufC-2c2gA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 2c2g THREONINE SYNTHASE
(Arabidopsis
thaliana) 		3 / 3 PRO A 215
THR A 239
LEU A 247
 None
 0.64A 3ttrA-2c2gA:
0.5		 3ttrA-2c2gA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 2c2g THREONINE SYNTHASE
(Arabidopsis
thaliana) 		5 / 12 ARG A 138
SER A 396
GLN A 393
GLY A 140
PHE A 139
 None
 1.26A 4r29A-2c2gA:
undetectable		 4r29A-2c2gA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 2c2g THREONINE SYNTHASE
(Arabidopsis
thaliana) 		5 / 10 PHE A 303
GLY A 295
LEU A 333
ALA A 368
ALA A 302
 None
 1.35A 4wnuD-2c2gA:
undetectable		 4wnuD-2c2gA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 2c2g THREONINE SYNTHASE
(Arabidopsis
thaliana) 		5 / 11 ALA A 201
VAL A 174
GLY A 207
SER A 210
GLY A 186
 None
 1.26A 4xp4A-2c2gA:
undetectable		 4xp4A-2c2gA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2c2g THREONINE SYNTHASE
(Arabidopsis
thaliana) 		5 / 12 SER A 220
MET A 391
MET A 388
THR A 192
GLY A 193
 None
None
None
None
PLP  A1163 ( 3.9A)
 1.12A 4zjlA-2c2gA:
undetectable		 4zjlA-2c2gA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 2c2g THREONINE SYNTHASE
(Arabidopsis
thaliana) 		4 / 5 PRO A 293
ALA A 325
ALA A 408
ILE A 291
 None
 0.82A 5jncD-2c2gA:
undetectable		 5jncD-2c2gA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2c2g THREONINE SYNTHASE
(Arabidopsis
thaliana) 		5 / 12 ASP A 389
ALA A 394
SER A 396
THR A 427
LEU A 144
 None
 1.43A 5m54B-2c2gA:
undetectable		 5m54B-2c2gA:
22.82