SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c2i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2c2i RV0130
(Mycobacterium
tuberculosis) 		4 / 8 THR A  58
GLY A 103
ALA A  61
ILE A  26
 None
 0.81A 1c9sI-2c2iA:
undetectable
1c9sJ-2c2iA:
undetectable		 1c9sI-2c2iA:
22.14
1c9sJ-2c2iA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 2c2i RV0130
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  91
ALA A 143
THR A 129
VAL A 131
 None
 0.58A 1dvxB-2c2iA:
undetectable		 1dvxB-2c2iA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2c2i RV0130
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 103
ALA A  61
ILE A  26
THR A  58
 None
 0.81A 1gtnA-2c2iA:
undetectable
1gtnK-2c2iA:
undetectable		 1gtnA-2c2iA:
22.14
1gtnK-2c2iA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2c2i RV0130
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 103
ALA A  61
ILE A  26
THR A  58
 None
 0.83A 1gtnP-2c2iA:
undetectable
1gtnQ-2c2iA:
undetectable		 1gtnP-2c2iA:
22.14
1gtnQ-2c2iA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 2c2i RV0130
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  70
LEU A  73
SER A  21
THR A 109
 None
 1.04A 1ictB-2c2iA:
undetectable		 1ictB-2c2iA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2c2i RV0130
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 103
ALA A  61
ILE A  26
THR A  58
 None
 0.79A 1utdB-2c2iA:
undetectable
1utdC-2c2iA:
undetectable		 1utdB-2c2iA:
22.14
1utdC-2c2iA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2c2i RV0130
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 103
ALA A  61
ILE A  26
THR A  58
 None
 0.81A 1utdI-2c2iA:
undetectable
1utdJ-2c2iA:
undetectable		 1utdI-2c2iA:
22.14
1utdJ-2c2iA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 2c2i RV0130
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  70
LEU A  73
SER A  21
THR A 109
 None
 1.07A 3cfqA-2c2iA:
undetectable		 3cfqA-2c2iA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 2c2i RV0130
(Mycobacterium
tuberculosis) 		4 / 7 SER A 110
LEU A  91
ALA A 143
THR A 129
 None
 0.73A 3cfqA-2c2iA:
undetectable
3cfqB-2c2iA:
undetectable		 3cfqA-2c2iA:
22.67
3cfqB-2c2iA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 2c2i RV0130
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  91
ALA A 143
THR A 129
VAL A 131
 None
 0.64A 3d2tA-2c2iA:
undetectable		 3d2tA-2c2iA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 2c2i RV0130
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  91
ALA A 143
THR A 129
VAL A 131
 None
 0.62A 3ozkB-2c2iA:
undetectable		 3ozkB-2c2iA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 2c2i RV0130
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  91
ALA A 143
THR A 129
VAL A 131
 None
 0.58A 4ik7A-2c2iA:
undetectable		 4ik7A-2c2iA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 2c2i RV0130
(Mycobacterium
tuberculosis) 		4 / 8 LEU A  91
ALA A 143
THR A 129
VAL A 131
 None
 0.56A 4ik7B-2c2iA:
undetectable		 4ik7B-2c2iA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 2c2i RV0130
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  91
ALA A 143
THR A 129
SER A 110
 None
 0.74A 4ikjA-2c2iA:
undetectable
4ikjB-2c2iA:
undetectable		 4ikjA-2c2iA:
23.03
4ikjB-2c2iA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2c2i RV0130
(Mycobacterium
tuberculosis) 		4 / 8 SER A 110
LEU A  91
ALA A 143
THR A 129
 None
 0.69A 4ikjA-2c2iA:
undetectable
4ikjB-2c2iA:
undetectable		 4ikjA-2c2iA:
23.03
4ikjB-2c2iA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2c2i RV0130
(Mycobacterium
tuberculosis) 		4 / 8 LEU A  91
ALA A 143
THR A 129
SER A 110
 None
 0.75A 4ikkA-2c2iA:
undetectable
4ikkB-2c2iA:
undetectable		 4ikkA-2c2iA:
23.03
4ikkB-2c2iA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 2c2i RV0130
(Mycobacterium
tuberculosis) 		4 / 7 SER A 110
LEU A  91
ALA A 143
THR A 129
 None
 0.71A 4ikkA-2c2iA:
undetectable
4ikkB-2c2iA:
undetectable		 4ikkA-2c2iA:
23.03
4ikkB-2c2iA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 2c2i RV0130
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  70
LEU A  73
SER A  21
THR A 109
 None
 1.11A 4iklA-2c2iA:
undetectable
4iklB-2c2iA:
undetectable		 4iklA-2c2iA:
23.03
4iklB-2c2iA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2c2i RV0130
(Mycobacterium
tuberculosis) 		4 / 6 PRO A  99
ILE A  44
VAL A  31
THR A  66
 None
 1.10A 4xe5A-2c2iA:
undetectable		 4xe5A-2c2iA:
9.51