SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c2l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 2c2l CARBOXY TERMINUS OF
HSP70-INTERACTING
PROTEIN
(Mus
musculus) 		4 / 7 LEU A  90
ALA A  61
TYR A  64
GLU A  89
 None
 0.83A 1dmaA-2c2lA:
undetectable		 1dmaA-2c2lA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2c2l CARBOXY TERMINUS OF
HSP70-INTERACTING
PROTEIN
(Mus
musculus) 		5 / 12 ILE A 236
ASP A 135
GLY A 133
ASN A 131
ALA A 139
 None
 1.23A 4eb4A-2c2lA:
undetectable		 4eb4A-2c2lA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2c2l CARBOXY TERMINUS OF
HSP70-INTERACTING
PROTEIN
(Mus
musculus) 		5 / 12 ILE A 236
ASP A 135
GLY A 133
ASN A 131
ALA A 139
 None
 1.25A 4eb4B-2c2lA:
undetectable		 4eb4B-2c2lA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2c2l CARBOXY TERMINUS OF
HSP70-INTERACTING
PROTEIN
(Mus
musculus) 		4 / 8 LEU A 276
LYS A 235
ILE A 236
GLY A 250
 None
 0.85A 4hb6A-2c2lA:
undetectable		 4hb6A-2c2lA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2c2l CARBOXY TERMINUS OF
HSP70-INTERACTING
PROTEIN
(Mus
musculus) 		3 / 3 ALA A 114
ASN A 117
LEU A 118
 None
SO4  A1306 (-3.8A)
None
 0.48A 5i1nC-2c2lA:
undetectable		 5i1nC-2c2lA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2c2l CARBOXY TERMINUS OF
HSP70-INTERACTING
PROTEIN
(Mus
musculus) 		5 / 10 MET A 108
SER A 110
LEU A 101
GLY A 102
ILE A  54
 None
 1.18A 5oy01-2c2lA:
undetectable
5oy07-2c2lA:
undetectable		 5oy01-2c2lA:
15.41
5oy07-2c2lA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 2c2l CARBOXY TERMINUS OF
HSP70-INTERACTING
PROTEIN
(Mus
musculus) 		4 / 7 ALA A  48
GLY A  51
TYR A  50
TYR A  63
 None
 1.05A 5uxdA-2c2lA:
undetectable		 5uxdA-2c2lA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2c2l CARBOXY TERMINUS OF
HSP70-INTERACTING
PROTEIN
(Mus
musculus) 		5 / 9 ILE A 236
ASP A 135
GLY A 133
ASN A 131
ALA A 139
 None
 1.28A 5x66C-2c2lA:
undetectable		 5x66C-2c2lA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 2c2l CARBOXY TERMINUS OF
HSP70-INTERACTING
PROTEIN
(Mus
musculus) 		5 / 10 ILE A 236
ASP A 135
GLY A 133
ASN A 131
ALA A 139
 None
 1.28A 5x66D-2c2lA:
undetectable		 5x66D-2c2lA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2c2l CARBOXY TERMINUS OF
HSP70-INTERACTING
PROTEIN
(Mus
musculus) 		5 / 7 GLN A 105
GLY A 102
PHE A  99
HIS A  98
VAL A  95
 SO4  A1306 (-3.2A)
None
None
None
None
 1.28A 6hu9S-2c2lA:
undetectable
6hu9q-2c2lA:
0.9		 6hu9S-2c2lA:
14.92
6hu9q-2c2lA:
19.78