SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c2n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		5 / 11 ALA A 248
LEU A 249
LEU A 245
LEU A 284
SER A 117
 None
 1.08A 1h9zA-2c2nA:
1.9		 1h9zA-2c2nA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		5 / 12 VAL A  51
LEU A  54
LEU A  46
PHE A 132
ALA A  91
 None
 1.07A 2aylA-2c2nA:
undetectable		 2aylA-2c2nA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		5 / 12 LEU A 318
ALA A 122
ALA A  95
VAL A 338
GLY A 315
 AE4  A1346 ( 4.7A)
None
None
None
SO4  A1341 (-3.3A)
 1.03A 3c6gB-2c2nA:
undetectable		 3c6gB-2c2nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		6 / 12 LEU A 318
ALA A 123
ALA A  95
GLY A 315
GLU A 311
VAL A 288
 AE4  A1346 ( 4.7A)
None
None
SO4  A1341 (-3.3A)
None
None
 1.41A 3c6gB-2c2nA:
undetectable		 3c6gB-2c2nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		5 / 12 LEU A 318
VAL A  96
GLY A 313
GLU A 311
VAL A 288
 AE4  A1346 ( 4.7A)
None
None
None
None
 1.01A 3c6gB-2c2nA:
undetectable		 3c6gB-2c2nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		4 / 7 LEU A 339
PRO A  32
SER A  92
GLY A  35
 None
AE4  A1346 (-4.2A)
None
None
 1.03A 3hcnA-2c2nA:
undetectable		 3hcnA-2c2nA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		4 / 7 LEU A 339
PRO A  32
SER A  92
GLY A  35
 None
AE4  A1346 (-4.2A)
None
None
 1.05A 3hcrB-2c2nA:
undetectable		 3hcrB-2c2nA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		5 / 9 VAL A 125
VAL A 118
GLN A  85
VAL A  61
GLY A 135
 None
 1.28A 3km6B-2c2nA:
0.0		 3km6B-2c2nA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		4 / 8 GLY A 183
PHE A 170
PHE A 219
PHE A 211
 None
 1.01A 3ko0D-2c2nA:
undetectable
3ko0E-2c2nA:
0.3		 3ko0D-2c2nA:
13.91
3ko0E-2c2nA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		4 / 8 PHE A 211
GLY A 183
PHE A 170
PHE A 219
 None
 0.89A 3ko0B-2c2nA:
undetectable
3ko0J-2c2nA:
0.3		 3ko0B-2c2nA:
13.91
3ko0J-2c2nA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		4 / 7 GLY A 183
PHE A 170
PHE A 219
PHE A 211
 None
 1.00A 3ko0L-2c2nA:
undetectable
3ko0N-2c2nA:
undetectable		 3ko0L-2c2nA:
13.91
3ko0N-2c2nA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		4 / 7 PHE A 211
GLY A 183
PHE A 170
PHE A 219
 None
 0.89A 3ko0K-2c2nA:
undetectable
3ko0S-2c2nA:
undetectable		 3ko0K-2c2nA:
13.91
3ko0S-2c2nA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		4 / 7 PHE A 211
GLY A 183
PHE A 170
PHE A 219
 None
 0.99A 3ko0R-2c2nA:
undetectable
3ko0T-2c2nA:
0.3		 3ko0R-2c2nA:
13.91
3ko0T-2c2nA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		4 / 4 VAL A 261
PHE A  31
PHE A 116
VAL A 288
 None
None
AE4  A1346 (-3.9A)
None
 1.40A 3rv5C-2c2nA:
0.2
3rv5D-2c2nA:
0.2		 3rv5C-2c2nA:
13.47
3rv5D-2c2nA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		3 / 3 PHE A 233
SER A 117
GLN A  85
 None
 0.94A 3smtA-2c2nA:
undetectable		 3smtA-2c2nA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		4 / 7 PRO A 257
GLY A 128
ALA A 127
ALA A 122
 None
 0.85A 3ur0B-2c2nA:
0.9		 3ur0B-2c2nA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		4 / 6 PHE A 121
ALA A 138
ALA A 143
LEU A 245
 None
 0.87A 4dtzA-2c2nA:
undetectable		 4dtzA-2c2nA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		5 / 11 GLY A  35
ALA A 320
ILE A 321
LEU A 195
MET A 157
 None
 1.16A 4xumB-2c2nA:
undetectable		 4xumB-2c2nA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		3 / 3 ARG A 269
HIS A 268
ARG A 271
 SO4  A1340 (-3.8A)
SO4  A1340 (-4.0A)
SO4  A1340 (-2.8A)
 0.90A 5iaoC-2c2nA:
undetectable		 5iaoC-2c2nA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		3 / 3 ARG A 269
HIS A 268
ARG A 271
 SO4  A1340 (-3.8A)
SO4  A1340 (-4.0A)
SO4  A1340 (-2.8A)
 0.90A 5iaoF-2c2nA:
undetectable		 5iaoF-2c2nA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		5 / 12 ILE A  88
GLY A  33
PHE A 233
ALA A  87
VAL A 139
 None
AE4  A1346 (-3.7A)
None
None
None
 1.15A 5n0oA-2c2nA:
undetectable		 5n0oA-2c2nA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		5 / 12 ILE A  88
GLY A  33
PHE A 233
ALA A  87
VAL A 139
 None
AE4  A1346 (-3.7A)
None
None
None
 1.15A 5n0oB-2c2nA:
undetectable		 5n0oB-2c2nA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		5 / 12 ILE A  88
GLY A  33
PHE A 233
ALA A  87
VAL A 139
 None
AE4  A1346 (-3.7A)
None
None
None
 1.15A 5n0rA-2c2nA:
undetectable		 5n0rA-2c2nA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		5 / 12 ILE A  88
GLY A  33
PHE A 233
ALA A  87
VAL A 139
 None
AE4  A1346 (-3.7A)
None
None
None
 1.15A 5n0wA-2c2nA:
undetectable		 5n0wA-2c2nA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		5 / 12 ILE A  88
GLY A  33
PHE A 233
ALA A  87
VAL A 139
 None
AE4  A1346 (-3.7A)
None
None
None
 1.15A 5n0xB-2c2nA:
undetectable		 5n0xB-2c2nA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		4 / 8 SER A  92
GLY A 119
ALA A 122
GLY A  33
 None
None
None
AE4  A1346 (-3.7A)
 0.74A 5vw9A-2c2nA:
undetectable		 5vw9A-2c2nA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE
(Homo
sapiens) 		5 / 12 LEU A 249
LEU A 280
GLY A 135
GLY A 128
TYR A 270
 None
 1.07A 6ce2B-2c2nA:
undetectable		 6ce2B-2c2nA:
14.83