SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c2q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 2c2q G/U
MISMATCH-SPECIFIC
DNA GLYCOSYLASE
(Deinococcus
radiodurans) 		3 / 3 TRP A  54
VAL A  68
PRO A  69
 None
 0.61A 1rg1A-2c2qA:
undetectable		 1rg1A-2c2qA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 2c2q G/U
MISMATCH-SPECIFIC
DNA GLYCOSYLASE
(Deinococcus
radiodurans) 		3 / 3 TRP A  54
VAL A  68
PRO A  69
 None
 0.62A 1rh0A-2c2qA:
undetectable		 1rh0A-2c2qA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2c2q G/U
MISMATCH-SPECIFIC
DNA GLYCOSYLASE
(Deinococcus
radiodurans) 		4 / 7 PHE A 120
VAL A  31
VAL A  29
LEU A  28
 None
 0.83A 3hs6B-2c2qA:
undetectable		 3hs6B-2c2qA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 2c2q G/U
MISMATCH-SPECIFIC
DNA GLYCOSYLASE
(Deinococcus
radiodurans) 		4 / 8 GLN A  23
PRO A  24
TYR A 113
PRO A 115
 None
 1.11A 3oyaA-2c2qA:
undetectable		 3oyaA-2c2qA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 2c2q G/U
MISMATCH-SPECIFIC
DNA GLYCOSYLASE
(Deinococcus
radiodurans) 		5 / 12 TRP A 173
THR A 121
LEU A  28
LEU A  62
PHE A  53
 None
 1.01A 4pbhA-2c2qA:
undetectable		 4pbhA-2c2qA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 2c2q G/U
MISMATCH-SPECIFIC
DNA GLYCOSYLASE
(Deinococcus
radiodurans) 		4 / 4 THR A 160
GLY A  32
ASP A  84
SER A 159
 None
ACT  A1190 ( 3.8A)
ACT  A1190 (-2.7A)
None
 1.28A 4rfqA-2c2qA:
undetectable		 4rfqA-2c2qA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 2c2q G/U
MISMATCH-SPECIFIC
DNA GLYCOSYLASE
(Deinococcus
radiodurans) 		5 / 12 THR A  56
GLY A 177
GLY A 140
LEU A 157
PRO A 158
 None
 1.46A 4uinH-2c2qA:
undetectable
4uinL-2c2qA:
undetectable		 4uinH-2c2qA:
25.40
4uinL-2c2qA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 2c2q G/U
MISMATCH-SPECIFIC
DNA GLYCOSYLASE
(Deinococcus
radiodurans) 		5 / 12 LEU A 183
GLY A  61
LEU A  57
ARG A 179
LEU A  28
 None
 1.23A 5emlA-2c2qA:
undetectable		 5emlA-2c2qA:
16.12