SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c2y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE
(Mycobacterium
tuberculosis) 		4 / 5 GLY A 175
LEU A 178
THR A 179
VAL A 163
 None
 0.80A 1ekjF-2c2yA:
undetectable
1ekjG-2c2yA:
undetectable		 1ekjF-2c2yA:
22.11
1ekjG-2c2yA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE
(Mycobacterium
tuberculosis) 		4 / 4 THR A  75
LEU A  78
LEU A  39
GLN A  47
 None
 1.13A 1fbmA-2c2yA:
undetectable		 1fbmA-2c2yA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 100
PRO A 101
LEU A 104
 None
 0.44A 1hrkA-2c2yA:
4.1		 1hrkA-2c2yA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 100
PRO A 101
LEU A 104
 None
 0.46A 2qd5B-2c2yA:
2.3		 2qd5B-2c2yA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  78
ILE A  73
PRO A 101
VAL A 274
 None
 1.03A 2ygoA-2c2yA:
undetectable		 2ygoA-2c2yA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE
(Mycobacterium
tuberculosis) 		5 / 9 ASP A 230
ILE A 229
VAL A 262
GLY A   8
ILE A 154
 None
 0.87A 3s43A-2c2yA:
undetectable		 3s43A-2c2yA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 100
LEU A 104
ASN A  79
ILE A  82
 None
 0.88A 3u5jA-2c2yA:
undetectable		 3u5jA-2c2yA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 100
PRO A 101
LEU A 104
 None
 0.40A 3w1wB-2c2yA:
2.8		 3w1wB-2c2yA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE
(Mycobacterium
tuberculosis) 		4 / 6 CYH A 140
THR A 141
ASP A 120
ILE A  95
 None
 1.33A 3w9tB-2c2yA:
undetectable		 3w9tB-2c2yA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE
(Mycobacterium
tuberculosis) 		4 / 6 CYH A 140
THR A 141
GLY A 121
ASP A 120
 None
 1.18A 3w9tE-2c2yA:
undetectable		 3w9tE-2c2yA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE
(Mycobacterium
tuberculosis) 		4 / 6 THR A 141
GLY A 121
ASP A 120
ILE A  95
 None
 1.03A 3w9tF-2c2yA:
undetectable		 3w9tF-2c2yA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE
(Mycobacterium
tuberculosis) 		4 / 6 THR A 169
GLY A 121
ASP A 120
ILE A  95
 None
 0.91A 3w9tF-2c2yA:
undetectable		 3w9tF-2c2yA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  62
LEU A 277
THR A  37
ILE A  95
LEU A 270
 None
 1.07A 4ej1B-2c2yA:
undetectable		 4ej1B-2c2yA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE
(Mycobacterium
tuberculosis) 		5 / 12 THR A 179
LEU A 178
ALA A 159
HIS A 160
GLN A 203
 None
 1.38A 4ejwA-2c2yA:
0.0		 4ejwA-2c2yA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 100
LEU A 104
ASN A  79
ILE A  82
 None
 0.92A 4lzrA-2c2yA:
undetectable		 4lzrA-2c2yA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 171
LEU A 177
ILE A 145
VAL A 163
VAL A 161
 None
 1.11A 5dpdB-2c2yA:
4.1		 5dpdB-2c2yA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  82
VAL A 113
ARG A  67
CYH A  57
LEU A  35
 None
 1.18A 5ergB-2c2yA:
5.0		 5ergB-2c2yA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 177
PRO A 142
GLY A 175
GLY A 171
LEU A 138
 None
 1.01A 5o96G-2c2yA:
undetectable
5o96H-2c2yA:
2.4		 5o96G-2c2yA:
19.05
5o96H-2c2yA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 143
ARG A  22
ARG A 280
 None
 1.02A 6bplA-2c2yA:
undetectable
6bplB-2c2yA:
undetectable		 6bplA-2c2yA:
19.90
6bplB-2c2yA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLN A  97
ASP A 120
THR A 141
VAL A 170
THR A 266
 None
 0.71A 6debB-2c2yA:
39.6		 6debB-2c2yA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLN A  97
LEU A  98
PRO A  99
ASP A 120
THR A 266
 None
 0.77A 6debB-2c2yA:
39.6		 6debB-2c2yA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE
(Mycobacterium
tuberculosis) 		4 / 5 TYR A  49
LYS A  53
GLN A  97
GLY A 212
 None
 0.91A 6debB-2c2yA:
39.6		 6debB-2c2yA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE
(Mycobacterium
tuberculosis) 		4 / 5 TYR A  49
LYS A  53
GLN A  97
GLY A 232
 None
 1.20A 6debB-2c2yA:
39.6		 6debB-2c2yA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 216
GLY A 212
VAL A 228
VAL A 207
ILE A 164
 None
 0.87A 6emuB-2c2yA:
2.1		 6emuB-2c2yA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 216
GLY A 212
VAL A 228
VAL A 207
ILE A 164
 None
 0.97A 6emuC-2c2yA:
undetectable		 6emuC-2c2yA:
17.96