SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c3b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2c3b PPIASE
(Aspergillus
fumigatus) 		4 / 8 GLY A  21
VAL A   8
GLU A   9
ILE A  23
 None
 0.92A 1pk7B-2c3bA:
undetectable		 1pk7B-2c3bA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 2c3b PPIASE
(Aspergillus
fumigatus) 		4 / 6 PHE A  25
PHE A  39
GLY A  67
GLY A  68
 None
 0.89A 2qr2A-2c3bA:
undetectable
2qr2B-2c3bA:
undetectable		 2qr2A-2c3bA:
23.47
2qr2B-2c3bA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 2c3b PPIASE
(Aspergillus
fumigatus) 		4 / 5 GLY A  67
GLY A  68
PHE A  25
PHE A  39
 None
 0.86A 2qr2A-2c3bA:
undetectable
2qr2B-2c3bA:
undetectable		 2qr2A-2c3bA:
23.47
2qr2B-2c3bA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 2c3b PPIASE
(Aspergillus
fumigatus) 		4 / 5 ILE A  59
PRO A 163
VAL A  32
PHE A   6
 None
None
SO4  A1172 (-3.5A)
None
 1.21A 2ygnA-2c3bA:
undetectable		 2ygnA-2c3bA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2c3b PPIASE
(Aspergillus
fumigatus) 		3 / 3 ALA A 120
GLN A  66
GLY A  67
 None
 0.51A 4odoC-2c3bA:
undetectable		 4odoC-2c3bA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 2c3b PPIASE
(Aspergillus
fumigatus) 		4 / 7 ILE A  65
PHE A  56
VAL A 144
ILE A  23
 None
 0.94A 4zzbC-2c3bA:
undetectable
4zzbD-2c3bA:
undetectable		 4zzbC-2c3bA:
20.00
4zzbD-2c3bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2c3b PPIASE
(Aspergillus
fumigatus) 		4 / 7 PHE A  56
HIS A  57
VAL A 157
SER A  54
 None
 1.00A 6hu9S-2c3bA:
undetectable
6hu9q-2c3bA:
undetectable		 6hu9S-2c3bA:
19.19
6hu9q-2c3bA:
22.16