SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c3n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2c3n GLUTATHIONE
S-TRANSFERASE THETA
1
(Homo
sapiens) 		3 / 3 THR A 136
LEU A 140
LEU A 147
 None
 0.44A 1mz9C-2c3nA:
undetectable		 1mz9C-2c3nA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ULV_A_ACRA3000_2
(GLUCODEXTRANASE)		 2c3n GLUTATHIONE
S-TRANSFERASE THETA
1
(Homo
sapiens) 		4 / 5 GLN A 102
GLU A 173
LEU A 191
TRP A 194
 None
 1.33A 1ulvA-2c3nA:
3.6		 1ulvA-2c3nA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 2c3n GLUTATHIONE
S-TRANSFERASE THETA
1
(Homo
sapiens) 		4 / 5 TRP A 194
ALA A 166
LEU A 152
ALA A 170
 None
 1.06A 2jstA-2c3nA:
undetectable
2jstB-2c3nA:
undetectable		 2jstA-2c3nA:
15.48
2jstB-2c3nA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 2c3n GLUTATHIONE
S-TRANSFERASE THETA
1
(Homo
sapiens) 		5 / 12 SER A  11
LEU A  35
PHE A  45
ASN A  49
ALA A  56
 None
 1.30A 3nuvA-2c3nA:
undetectable		 3nuvA-2c3nA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_B_ASDB126_1
(STEROID
DELTA-ISOMERASE)		 2c3n GLUTATHIONE
S-TRANSFERASE THETA
1
(Homo
sapiens) 		6 / 10 SER A  11
LEU A  35
PHE A  45
VAL A  33
ASN A  49
ALA A  56
 None
 1.44A 3nuvB-2c3nA:
0.0		 3nuvB-2c3nA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB511_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2c3n GLUTATHIONE
S-TRANSFERASE THETA
1
(Homo
sapiens) 		4 / 5 SER A 109
GLU A 173
LEU A 106
GLN A 102
 None
 1.30A 3pgyB-2c3nA:
0.0		 3pgyB-2c3nA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2c3n GLUTATHIONE
S-TRANSFERASE THETA
1
(Homo
sapiens) 		4 / 4 LYS A 216
GLN A 208
ILE A  19
LEU A   7
 None
 1.17A 3qt0A-2c3nA:
0.9		 3qt0A-2c3nA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 2c3n GLUTATHIONE
S-TRANSFERASE THETA
1
(Homo
sapiens) 		3 / 3 VAL A 128
SER A 129
THR A 132
 None
 0.28A 4luhA-2c3nA:
undetectable		 4luhA-2c3nA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2c3n GLUTATHIONE
S-TRANSFERASE THETA
1
(Homo
sapiens) 		3 / 3 HIS A 116
VAL A 184
LEU A 140
 None
 0.75A 4m2vA-2c3nA:
undetectable		 4m2vA-2c3nA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2c3n GLUTATHIONE
S-TRANSFERASE THETA
1
(Homo
sapiens) 		4 / 5 ILE A 171
ARG A 197
GLU A 199
VAL A 178
 None
 1.16A 4nkxC-2c3nA:
undetectable		 4nkxC-2c3nA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2c3n GLUTATHIONE
S-TRANSFERASE THETA
1
(Homo
sapiens) 		4 / 5 ILE A 171
ARG A 197
GLU A 199
VAL A 178
 None
 1.17A 4nkxD-2c3nA:
undetectable		 4nkxD-2c3nA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 2c3n GLUTATHIONE
S-TRANSFERASE THETA
1
(Homo
sapiens) 		3 / 3 HIS A 162
SER A 164
ARG A  94
 None
 0.84A 5u63A-2c3nA:
undetectable		 5u63A-2c3nA:
23.42