SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c3o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 11 ILE A 559
LEU A 512
LEU A 425
GLY A 424
ALA A 493
 None
 1.07A 1b02A-2c3oA:
undetectable		 1b02A-2c3oA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 ALA A 385
LEU A 359
PHE A 390
ILE A 273
LEU A 327
 None
 1.26A 1dreA-2c3oA:
undetectable		 1dreA-2c3oA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 8 SER A 279
ILE A 300
VAL A 378
MET A 382
 None
 1.13A 1kb9A-2c3oA:
undetectable
1kb9C-2c3oA:
undetectable
1kb9D-2c3oA:
undetectable
1kb9E-2c3oA:
undetectable		 1kb9A-2c3oA:
16.79
1kb9C-2c3oA:
14.20
1kb9D-2c3oA:
11.72
1kb9E-2c3oA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 6 TYR A 479
HIS A 467
GLU A 285
PRO A 414
 None
 1.27A 1q13A-2c3oA:
undetectable		 1q13A-2c3oA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 VAL A 606
ALA A 437
ALA A 579
VAL A 573
ALA A 571
 None
 1.19A 1sa1C-2c3oA:
3.4
1sa1D-2c3oA:
3.3		 1sa1C-2c3oA:
16.90
1sa1D-2c3oA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 7 ASP A 990
GLY A 839
ILE A 843
THR A 818
 None
TPP  A2236 (-3.3A)
None
None
 0.73A 1t7iB-2c3oA:
undetectable		 1t7iB-2c3oA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 7 ASP A 990
GLY A 839
ILE A 843
THR A 818
 None
TPP  A2236 (-3.3A)
None
None
 0.74A 1t7jB-2c3oA:
undetectable		 1t7jB-2c3oA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		3 / 3 ASP A 428
ILE A 544
VAL A 553
 None
 0.71A 2avvD-2c3oA:
undetectable		 2avvD-2c3oA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 PHE A 470
ALA A 566
ASN A 560
ILE A 441
ILE A 438
 None
 1.18A 2bjfA-2c3oA:
undetectable		 2bjfA-2c3oA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		3 / 3 LYS A 293
ASP A 411
ASP A 485
 None
 1.11A 2br4A-2c3oA:
2.5		 2br4A-2c3oA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 7 MET A 276
ASP A 328
TYR A 363
HIS A 127
 None
 1.43A 2bytA-2c3oA:
undetectable		 2bytA-2c3oA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 7 MET A 276
ASP A 328
TYR A 363
HIS A 127
 None
 1.44A 2bytD-2c3oA:
undetectable		 2bytD-2c3oA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_A_CHDA1_0
(LIVER
CARBOXYLESTERASE 1)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 5 GLY A1043
LYS A1046
LEU A 796
PRO A 756
 None
 1.04A 2dqyA-2c3oA:
2.8		 2dqyA-2c3oA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 ILE A 242
ALA A 159
VAL A 165
ALA A 139
LEU A 260
 None
 1.18A 2japA-2c3oA:
2.4		 2japA-2c3oA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 ILE A 242
ALA A 159
VAL A 165
ALA A 139
LEU A 260
 None
 1.17A 2japB-2c3oA:
2.3		 2japB-2c3oA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 ILE A 242
ALA A 159
VAL A 165
ALA A 139
LEU A 260
 None
 1.17A 2japC-2c3oA:
3.0		 2japC-2c3oA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 ILE A 242
ALA A 159
VAL A 165
ALA A 139
LEU A 260
 None
 1.19A 2japD-2c3oA:
2.4		 2japD-2c3oA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 11 LEU A 893
LEU A 941
ILE A 945
ALA A 902
LEU A 930
 None
 1.22A 2q72A-2c3oA:
undetectable		 2q72A-2c3oA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 PHE A 470
ALA A 566
ASN A 560
ILE A 441
ILE A 438
 None
 1.17A 2rlcA-2c3oA:
undetectable		 2rlcA-2c3oA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 8 ASP A 963
SER A1002
TYR A 994
TYR A  28
 MG  A2237 ( 2.6A)
None
TPP  A2236 (-4.5A)
None
 1.36A 2v0gA-2c3oA:
undetectable		 2v0gA-2c3oA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_B_CSCB1384_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 LEU A 340
TYR A 131
GLN A 135
HIS A 127
PHE A 170
 None
 1.27A 2vavB-2c3oA:
0.7		 2vavB-2c3oA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_C_CSCC1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 LEU A 340
TYR A 131
GLN A 135
HIS A 127
PHE A 170
 None
 1.26A 2vavC-2c3oA:
0.7		 2vavC-2c3oA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_D_CSCD1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 LEU A 340
TYR A 131
GLN A 135
HIS A 127
PHE A 170
 None
 1.27A 2vavD-2c3oA:
0.6		 2vavD-2c3oA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_I_CSCI1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 LEU A 340
TYR A 131
GLN A 135
HIS A 127
PHE A 170
 None
 1.28A 2vavI-2c3oA:
0.7		 2vavI-2c3oA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_A_CSCA1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 LEU A 340
TYR A 131
GLN A 135
HIS A 127
PHE A 170
 None
 1.24A 2vaxA-2c3oA:
0.0		 2vaxA-2c3oA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_B_CSCB1384_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 LEU A 340
TYR A 131
GLN A 135
HIS A 127
PHE A 170
 None
 1.24A 2vaxB-2c3oA:
0.7		 2vaxB-2c3oA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_D_CSCD1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 LEU A 340
TYR A 131
GLN A 135
HIS A 127
PHE A 170
 None
 1.19A 2vaxD-2c3oA:
0.7		 2vaxD-2c3oA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_E_CSCE1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 LEU A 340
TYR A 131
GLN A 135
HIS A 127
PHE A 170
 None
 1.23A 2vaxE-2c3oA:
0.0		 2vaxE-2c3oA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_F_CSCF1384_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 LEU A 340
TYR A 131
GLN A 135
HIS A 127
PHE A 170
 None
 1.29A 2vaxF-2c3oA:
0.7		 2vaxF-2c3oA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_G_CSCG1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 LEU A 340
TYR A 131
GLN A 135
HIS A 127
PHE A 170
 None
 1.24A 2vaxG-2c3oA:
0.1		 2vaxG-2c3oA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_H_CSCH1383_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 LEU A 340
TYR A 131
GLN A 135
HIS A 127
PHE A 170
 None
 1.34A 2vaxH-2c3oA:
0.5		 2vaxH-2c3oA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_I_CSCI1384_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 LEU A 340
TYR A 131
GLN A 135
HIS A 127
PHE A 170
 None
 1.23A 2vaxI-2c3oA:
0.6		 2vaxI-2c3oA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_J_CSCJ1385_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 LEU A 340
TYR A 131
GLN A 135
HIS A 127
PHE A 170
 None
 1.21A 2vaxJ-2c3oA:
0.5		 2vaxJ-2c3oA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_K_CSCK1385_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 LEU A 340
TYR A 131
GLN A 135
HIS A 127
PHE A 170
 None
 1.22A 2vaxK-2c3oA:
0.5		 2vaxK-2c3oA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_1
(PTERIDINE REDUCTASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 SER A1058
PHE A1059
PHE A1175
LEU A 978
PRO A1062
 None
 1.44A 2x9gA-2c3oA:
1.9		 2x9gA-2c3oA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_C_LYAC1270_1
(PTERIDINE REDUCTASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 SER A1058
PHE A1059
PHE A1175
LEU A 978
PRO A1062
 None
 1.47A 2x9gC-2c3oA:
2.1		 2x9gC-2c3oA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_D_LYAD1270_1
(PTERIDINE REDUCTASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 SER A1058
PHE A1059
PHE A1175
LEU A 978
PRO A1062
 None
 1.45A 2x9gD-2c3oA:
3.5		 2x9gD-2c3oA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 7 GLU A 281
TYR A 258
ARG A 303
SER A 145
 None
 1.14A 2zt7A-2c3oA:
2.4		 2zt7A-2c3oA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 7 LEU A 327
SER A 278
THR A 282
VAL A 286
 None
 0.78A 3d2tA-2c3oA:
undetectable		 3d2tA-2c3oA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 8 ARG A1133
TYR A1068
GLU A1162
GLU A1155
 None
 1.43A 3dh0A-2c3oA:
2.6		 3dh0A-2c3oA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 GLY A1094
ALA A1090
THR A1089
GLU A 992
ALA A1153
 None
 1.09A 3g8bB-2c3oA:
undetectable		 3g8bB-2c3oA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 PHE A 370
GLY A 277
SER A 279
ASP A 172
ILE A 130
 None
 1.21A 3iv6B-2c3oA:
undetectable		 3iv6B-2c3oA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 TYR A 498
GLY A 461
GLY A 462
ALA A 427
VAL A 677
 None
 0.96A 3jb2A-2c3oA:
undetectable		 3jb2A-2c3oA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 GLY A 961
VAL A 986
GLY A 964
LEU A1025
ILE A1066
 None
None
TPP  A2236 (-3.2A)
None
None
 0.91A 3ku1C-2c3oA:
undetectable		 3ku1C-2c3oA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 10 LEU A 914
ALA A 897
VAL A 906
GLY A 943
LEU A 910
 None
 0.89A 3ogqA-2c3oA:
undetectable		 3ogqA-2c3oA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 10 ILE A 559
ASP A 428
LEU A 613
ILE A 534
ILE A 504
 None
 1.20A 3prsA-2c3oA:
undetectable		 3prsA-2c3oA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 8 PHE A 828
ILE A 834
LEU A1053
PHE A 987
 None
 0.90A 3rqwI-2c3oA:
undetectable
3rqwJ-2c3oA:
undetectable		 3rqwI-2c3oA:
13.59
3rqwJ-2c3oA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 ALA A1056
TYR A 967
LEU A 978
ALA A1038
VAL A1035
 None
 1.00A 3rukA-2c3oA:
undetectable		 3rukA-2c3oA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 ALA A1106
MET A1030
GLY A1033
TYR A1036
ALA A1026
 None
 1.19A 3tm4A-2c3oA:
2.7		 3tm4A-2c3oA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 ALA A1106
MET A1030
GLY A1033
TYR A1036
ALA A1026
 None
 1.19A 3tm4B-2c3oA:
3.0		 3tm4B-2c3oA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 ILE A 559
LEU A 512
LEU A 425
GLY A 424
ALA A 493
 None
 0.97A 3uwlB-2c3oA:
undetectable		 3uwlB-2c3oA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 5 GLU A 230
GLY A 228
TYR A 225
GLN A 220
 None
 0.84A 3w9tB-2c3oA:
undetectable		 3w9tB-2c3oA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 5 GLU A 230
GLY A 228
TYR A 225
GLN A 220
 None
 0.97A 3w9tD-2c3oA:
undetectable		 3w9tD-2c3oA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 6 GLU A 472
LYS A 473
PRO A 414
LYS A 415
 None
 1.36A 4a7tF-2c3oA:
undetectable		 4a7tF-2c3oA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 7 PHE A 313
PHE A 308
PHE A 348
LEU A 340
 None
 0.95A 4ejgA-2c3oA:
undetectable		 4ejgA-2c3oA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		3 / 3 LEU A 890
MET A 948
ASP A 905
 None
 0.79A 4j7xB-2c3oA:
undetectable		 4j7xB-2c3oA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 8 HIS A  16
ASP A 190
LEU A 186
ASP A 151
 None
 1.04A 4l7iA-2c3oA:
undetectable		 4l7iA-2c3oA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		3 / 3 ARG A1147
GLU A1143
ARG A1019
 None
 0.78A 4mwvA-2c3oA:
undetectable		 4mwvA-2c3oA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJG_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 ASP A 411
THR A 412
THR A 282
GLU A 284
GLN A 419
 None
 1.38A 4njgB-2c3oA:
1.1		 4njgB-2c3oA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 5 GLN A  88
LEU A 121
ASP A 126
ASP A 328
 None
PYR  A2239 ( 4.7A)
None
None
 1.23A 4qtuD-2c3oA:
2.5		 4qtuD-2c3oA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		3 / 3 SER A 371
ASP A 397
ASP A 652
 None
 0.72A 4uckA-2c3oA:
undetectable		 4uckA-2c3oA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 8 HIS A 701
ASP A 744
SER A 670
PRO A 852
 None
 0.91A 4uhxA-2c3oA:
undetectable		 4uhxA-2c3oA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 8 HIS A 701
ASP A 744
SER A 670
ARG A 675
PRO A 852
 None
 1.25A 4uhxA-2c3oA:
undetectable		 4uhxA-2c3oA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 PHE A 124
PRO A  32
THR A  31
ARG A 114
GLY A 839
 None
None
PYR  A2239 (-3.6A)
PYR  A2239 (-3.0A)
TPP  A2236 (-3.3A)
 1.17A 4ydqB-2c3oA:
2.1		 4ydqB-2c3oA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 LEU A 893
ALA A 897
LEU A 934
LEU A 942
LEU A 910
 None
 1.08A 4zn7A-2c3oA:
undetectable		 4zn7A-2c3oA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 6 ALA A1038
SER A1058
ASP A1102
PRO A1103
 None
 1.07A 5c6pA-2c3oA:
undetectable		 5c6pA-2c3oA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 9 VAL A 495
ILE A 534
PHE A 541
TRP A 516
LEU A 512
 None
 1.08A 5e4dA-2c3oA:
0.0		 5e4dA-2c3oA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 11 VAL A 495
ILE A 534
PHE A 541
TRP A 516
LEU A 512
 None
 1.06A 5e4dB-2c3oA:
undetectable		 5e4dB-2c3oA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 11 ILE A 559
LEU A 512
LEU A 425
GLY A 424
ALA A 493
 None
 1.03A 5fctA-2c3oA:
undetectable		 5fctA-2c3oA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 ILE A 559
LEU A 512
LEU A 425
GLY A 424
ALA A 493
 None
 0.93A 5j7wC-2c3oA:
undetectable		 5j7wC-2c3oA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 ILE A 559
LEU A 512
LEU A 425
GLY A 424
ALA A 493
 None
 0.94A 5j7wD-2c3oA:
undetectable		 5j7wD-2c3oA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 5 LEU A 724
CYH A 689
CYH A 755
LEU A 762
 None
SF4  A2233 (-2.3A)
SF4  A2233 (-2.3A)
SF4  A2233 (-4.3A)
 1.02A 5mafA-2c3oA:
undetectable		 5mafA-2c3oA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 LEU A 501
ASP A 499
ILE A 504
GLY A 503
VAL A 487
 None
 0.75A 5twjC-2c3oA:
undetectable		 5twjC-2c3oA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 11 LEU A 501
ASP A 499
ILE A 504
GLY A 503
VAL A 487
 None
 0.78A 5twjD-2c3oA:
undetectable		 5twjD-2c3oA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 8 THR A 282
ASN A 288
PRO A 414
TYR A 479
 None
 1.29A 5v4vA-2c3oA:
undetectable		 5v4vA-2c3oA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		4 / 8 THR A 282
ASN A 288
PRO A 414
TYR A 479
 None
 1.31A 5v4vB-2c3oA:
undetectable		 5v4vB-2c3oA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 VAL A 823
THR A 825
PHE A 987
PHE A 960
VAL A1065
 None
 1.35A 6a93B-2c3oA:
3.0		 6a93B-2c3oA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 VAL A 823
THR A 825
TRP A 958
PHE A 987
PHE A 960
 None
 1.29A 6a93B-2c3oA:
3.0		 6a93B-2c3oA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 ILE A 161
ASN A  50
THR A  57
LEU A  56
SER A 163
 None
 1.11A 6baaE-2c3oA:
2.5		 6baaE-2c3oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 ILE A 161
ASN A  50
THR A  57
LEU A  56
SER A 163
 None
 1.11A 6baaF-2c3oA:
2.7		 6baaF-2c3oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 ILE A 161
ASN A  50
THR A  57
LEU A  56
SER A 163
 None
 1.12A 6baaG-2c3oA:
2.6		 6baaG-2c3oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 ILE A 161
ASN A  50
THR A  57
LEU A  56
SER A 163
 None
 1.12A 6baaH-2c3oA:
0.2		 6baaH-2c3oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		3 / 3 ALA A 571
PHE A 568
GLN A 564
 None
 0.82A 6eceA-2c3oA:
4.3		 6eceA-2c3oA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 ILE A 559
LEU A 512
LEU A 425
GLY A 424
ALA A 493
 None
 1.06A 6r2eE-2c3oA:
undetectable		 6r2eE-2c3oA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 11 ILE A 559
LEU A 512
LEU A 425
GLY A 424
ALA A 493
 None
 1.02A 6r2eF-2c3oA:
undetectable		 6r2eF-2c3oA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE
(Desulfovibrio
africanus) 		5 / 12 ILE A 559
LEU A 512
LEU A 425
GLY A 424
ALA A 493
 None
 1.24A 6r2eH-2c3oA:
undetectable		 6r2eH-2c3oA:
13.74