SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c3z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Sulfolobus
solfataricus) 		5 / 9 LEU A  38
ILE A  37
ASN A  34
ARG A 175
ALA A 229
 None
 1.21A 1e7aA-2c3zA:
undetectable		 1e7aA-2c3zA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Sulfolobus
solfataricus) 		4 / 7 GLU A 210
GLU A 159
ILE A 133
LEU A  83
 None
 1.47A 1q0yH-2c3zA:
undetectable
1q0yL-2c3zA:
undetectable		 1q0yH-2c3zA:
19.34
1q0yL-2c3zA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Sulfolobus
solfataricus) 		4 / 7 LEU A  38
GLY A 178
ILE A 177
ILE A  37
 None
 0.66A 2aojB-2c3zA:
undetectable		 2aojB-2c3zA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Sulfolobus
solfataricus) 		5 / 9 TYR A  69
LEU A  33
ARG A  36
LEU A 231
ALA A  77
 None
 1.12A 2bxeA-2c3zA:
undetectable		 2bxeA-2c3zA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Sulfolobus
solfataricus) 		5 / 10 TYR A  69
LEU A  33
ARG A  36
LEU A 231
ALA A  77
 None
 1.12A 2bxeB-2c3zA:
undetectable		 2bxeB-2c3zA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Sulfolobus
solfataricus) 		3 / 3 MET A 109
VAL A  78
GLU A 210
 None
 0.82A 2x9gA-2c3zA:
undetectable		 2x9gA-2c3zA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Sulfolobus
solfataricus) 		4 / 7 GLU A  39
ALA A 229
ASN A  41
ALA A  47
 None
 1.08A 2zgwA-2c3zA:
undetectable		 2zgwA-2c3zA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Sulfolobus
solfataricus) 		4 / 6 GLU A  39
ALA A 229
ASN A  41
ALA A  47
 None
 1.10A 2zgwB-2c3zA:
undetectable		 2zgwB-2c3zA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Sulfolobus
solfataricus) 		4 / 8 LEU A 145
ILE A 119
ARG A 150
GLY A 153
 None
 0.91A 3b9lA-2c3zA:
undetectable		 3b9lA-2c3zA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Sulfolobus
solfataricus) 		4 / 6 LEU A 231
GLU A 210
ASN A 180
SER A  81
 None
 1.42A 3i9jB-2c3zA:
undetectable		 3i9jB-2c3zA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Sulfolobus
solfataricus) 		4 / 7 LEU A 157
ALA A 229
GLY A 226
ILE A 198
 None
 0.83A 3spkB-2c3zA:
undetectable		 3spkB-2c3zA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Sulfolobus
solfataricus) 		4 / 7 PRO A 106
ILE A  31
ARG A  36
SER A 104
 None
 0.96A 4a3uB-2c3zA:
11.9		 4a3uB-2c3zA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Sulfolobus
solfataricus) 		4 / 8 ILE A 213
GLY A 212
VAL A 227
SER A 199
 None
SO4  A1000 (-4.4A)
None
None
 0.77A 4acbB-2c3zA:
2.3
4acbC-2c3zA:
2.3		 4acbB-2c3zA:
21.76
4acbC-2c3zA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Sulfolobus
solfataricus) 		3 / 3 SER A 181
ALA A 209
VAL A 208
 None
 0.40A 4x20C-2c3zA:
undetectable		 4x20C-2c3zA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 SER A 211
LEU A 187
PHE A  89
LEU A 131
LEU A 231
 SO4  A1000 ( 3.9A)
None
None
None
None
 1.44A 5y2oA-2c3zA:
0.0		 5y2oA-2c3zA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE
(Sulfolobus
solfataricus) 		5 / 12 VAL A  78
ILE A 119
GLY A 153
ALA A 127
ALA A 122
 None
 1.05A 6c2mD-2c3zA:
undetectable		 6c2mD-2c3zA:
16.04