SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c40'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN
(Bacillus
anthracis) 		3 / 3 ARG A 156
ILE A 194
TRP A 246
 None
 0.98A 1nodB-2c40A:
undetectable		 1nodB-2c40A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN
(Bacillus
anthracis) 		4 / 8 VAL A 231
ASP A  13
ASP A 247
HIS A  80
 None
None
RIB  A1312 ( 2.5A)
None
 1.15A 1pk2A-2c40A:
undetectable		 1pk2A-2c40A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN
(Bacillus
anthracis) 		3 / 3 PHE A 175
ARG A 156
ASN A 160
 None
None
RIB  A1312 (-3.3A)
 0.91A 1xzxX-2c40A:
undetectable		 1xzxX-2c40A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN
(Bacillus
anthracis) 		3 / 3 ARG A 156
ILE A 194
TRP A 246
 None
 0.98A 2nodB-2c40A:
undetectable		 2nodB-2c40A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN
(Bacillus
anthracis) 		3 / 3 ARG A 156
ILE A 194
TRP A 246
 None
 1.00A 3e6tB-2c40A:
undetectable		 3e6tB-2c40A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN
(Bacillus
anthracis) 		5 / 10 LEU A  20
VAL A 248
VAL A  16
LEU A 224
LYS A 308
 None
 1.07A 3gwxA-2c40A:
undetectable		 3gwxA-2c40A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN
(Bacillus
anthracis) 		3 / 3 THR A  59
LYS A 144
GLU A  61
 None
 0.99A 3ijdB-2c40A:
undetectable		 3ijdB-2c40A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN
(Bacillus
anthracis) 		4 / 8 THR A 112
LEU A 109
ALA A  63
SER A  33
 None
 1.03A 3kp6A-2c40A:
undetectable		 3kp6A-2c40A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN
(Bacillus
anthracis) 		5 / 11 VAL A 184
ALA A 132
TYR A 136
ALA A 105
PHE A 124
 None
 1.31A 3qxyB-2c40A:
undetectable
3qxyQ-2c40A:
undetectable		 3qxyB-2c40A:
23.21
3qxyQ-2c40A:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN
(Bacillus
anthracis) 		4 / 8 ALA A  81
VAL A  84
ASP A  85
LEU A  90
 None
 0.34A 3roxA-2c40A:
4.0		 3roxA-2c40A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN
(Bacillus
anthracis) 		3 / 3 PHE A  55
VAL A  32
ILE A  60
 None
 0.50A 4emaA-2c40A:
undetectable		 4emaA-2c40A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN
(Bacillus
anthracis) 		4 / 8 LEU A 122
VAL A  32
SER A  33
HIS A   8
 None
 0.89A 4qknA-2c40A:
undetectable		 4qknA-2c40A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN
(Bacillus
anthracis) 		4 / 8 ASP A  14
ASP A 247
TYR A 243
ASP A  13
 CA  A1311 ( 2.3A)
RIB  A1312 ( 2.5A)
None
None
 0.81A 4xjeA-2c40A:
undetectable		 4xjeA-2c40A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN
(Bacillus
anthracis) 		4 / 8 ALA A 182
VAL A 181
THR A 129
GLY A 277
 None
 0.94A 5v0vA-2c40A:
undetectable		 5v0vA-2c40A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN
(Bacillus
anthracis) 		4 / 7 ILE A 189
LEU A 109
THR A 125
THR A 116
 None
 0.95A 5vc0A-2c40A:
undetectable		 5vc0A-2c40A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN
(Bacillus
anthracis) 		5 / 12 PHE A 300
PHE A 299
LEU A 204
LEU A 224
TYR A 228
 None
 1.24A 5y2oA-2c40A:
undetectable		 5y2oA-2c40A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN
(Bacillus
anthracis) 		5 / 11 GLU A 171
GLY A  69
ASP A 177
ALA A  37
ILE A  35
 RIB  A1312 (-3.8A)
None
None
None
None
 1.18A 5yk2A-2c40A:
undetectable		 5yk2A-2c40A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZGB_B_PQNB844_1
(PSAB)		 2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN
(Bacillus
anthracis) 		5 / 9 ILE A 110
ARG A 183
ALA A 132
LEU A 135
ALA A 187
 None
 1.29A 5zgbB-2c40A:
undetectable		 5zgbB-2c40A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN
(Bacillus
anthracis) 		4 / 4 HIS A   8
VAL A  84
LEU A  15
ALA A  44
 None
 1.19A 6d8pB-2c40A:
undetectable		 6d8pB-2c40A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN
(Bacillus
anthracis) 		3 / 3 GLY A 126
ASP A 247
ILE A 194
 CA  A1311 ( 4.2A)
RIB  A1312 ( 2.5A)
None
 0.59A 6dgxB-2c40A:
undetectable		 6dgxB-2c40A:
12.10