SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c45'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 2c45 ASPARTATE
1-DECARBOXYLASE
PRECURSOR
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  36
ASP A  37
ILE A  28
ILE A  88
ALA A  13
 None
 1.04A 1sguB-2c45A:
2.4		 1sguB-2c45A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 2c45 ASPARTATE
1-DECARBOXYLASE
PRECURSOR
(Mycobacterium
tuberculosis) 		5 / 12 THR A  45
LEU A  55
ILE A  46
VAL A  85
ASN A  51
 None
 1.22A 1wsvA-2c45A:
undetectable		 1wsvA-2c45A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 2c45 ASPARTATE
1-DECARBOXYLASE
PRECURSOR
(Mycobacterium
tuberculosis) 		5 / 12 THR A  45
LEU A  55
ILE A  46
VAL A  85
ASN A  51
 None
 1.21A 1wsvB-2c45A:
undetectable		 1wsvB-2c45A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2c45 ASPARTATE
1-DECARBOXYLASE
PRECURSOR
(Mycobacterium
tuberculosis) 		4 / 5 GLY A  41
ILE A  60
VAL A  44
SER A  25
 None
 1.18A 4d33A-2c45A:
undetectable		 4d33A-2c45A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2c45 ASPARTATE
1-DECARBOXYLASE
PRECURSOR
(Mycobacterium
tuberculosis) 		4 / 5 GLY A  41
ILE A  60
VAL A  44
SER A  25
 None
 1.18A 4d33B-2c45A:
undetectable		 4d33B-2c45A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2c45 ASPARTATE
1-DECARBOXYLASE
PRECURSOR
(Mycobacterium
tuberculosis) 		4 / 6 GLU A  63
GLY A  65
GLY A  67
ASP A  29
 None
 0.90A 5a06D-2c45A:
undetectable		 5a06D-2c45A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 2c45 ASPARTATE
1-DECARBOXYLASE
PRECURSOR
(Mycobacterium
tuberculosis) 		4 / 6 TYR A  90
LEU A  87
GLU A  42
LEU A  38
 None
 1.19A 5xooA-2c45A:
undetectable		 5xooA-2c45A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 2c45 ASPARTATE
1-DECARBOXYLASE
PRECURSOR
(Mycobacterium
tuberculosis) 		4 / 5 LEU A  87
VAL A  44
GLU A  42
LEU A  38
 None
 0.84A 5xooB-2c45A:
undetectable		 5xooB-2c45A:
19.42