SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c46'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1H4O_A_BEZA1162_0 (PEROXIREDOXIN 5)	2c46	MRNA CAPPING ENZYME (Homo sapiens)	5 / 10	GLY A 129 LEU A 50 PHE A 45 ARG A 160 GLY A 123	None	1.24A	1h4oA-2c46A: undetectable 1h4oB-2c46A: undetectable	1h4oA-2c46A: 21.14 1h4oB-2c46A: 21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HRC_A_CHDA703_0 (FERROCHELATASE)	2c46	MRNA CAPPING ENZYME (Homo sapiens)	4 / 4	LEU A 25 PRO A 26 LEU A 27 ARG A 15	None	1.34A	2hrcA-2c46A: undetectable	2hrcA-2c46A: 19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N58_C_ADNC500_1 (ADENOSYLHOMOCYSTEINA SE)	2c46	MRNA CAPPING ENZYME (Homo sapiens)	5 / 12	THR A 70 LYS A 88 ASP A 66 LEU A 31 HIS A 125	None	1.46A	3n58C-2c46A: undetectable	3n58C-2c46A: 18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N58_D_ADND500_1 (ADENOSYLHOMOCYSTEINA SE)	2c46	MRNA CAPPING ENZYME (Homo sapiens)	5 / 12	THR A 70 LYS A 88 ASP A 66 LEU A 31 HIS A 125	None	1.43A	3n58D-2c46A: undetectable	3n58D-2c46A: 18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NQA_A_9CRA501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	2c46	MRNA CAPPING ENZYME (Homo sapiens)	5 / 11	PHE A 156 ALA A 152 CYH A 126 HIS A 125 LEU A 67	None	1.14A	4nqaA-2c46A: undetectable	4nqaA-2c46A: 21.39

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1H4O_A_BEZA1162_0","PEROXIREDOXIN 5","2c46","MRNA CAPPING ENZYME","Homo sapiens",5,"GLY A 129;LEU A  50;PHE A  45;ARG A 160;GLY A 123","None","1.24A","1h4oA-2c46A:undetectable;1h4oB-2c46A:undetectable","1h4oA-2c46A:21.14;1h4oB-2c46A:21.14"],["2HRC_A_CHDA703_0","FERROCHELATASE","2c46","MRNA CAPPING ENZYME","Homo sapiens",4,"LEU A  25;PRO A  26;LEU A  27;ARG A  15","None","1.34A","2hrcA-2c46A:undetectable","2hrcA-2c46A:19.72"],["3N58_C_ADNC500_1","ADENOSYLHOMOCYSTEINASE","2c46","MRNA CAPPING ENZYME","Homo sapiens",5,"THR A  70;LYS A  88;ASP A  66;LEU A  31;HIS A 125","None","1.46A","3n58C-2c46A:undetectable","3n58C-2c46A:18.95"],["3N58_D_ADND500_1","ADENOSYLHOMOCYSTEINASE","2c46","MRNA CAPPING ENZYME","Homo sapiens",5,"THR A  70;LYS A  88;ASP A  66;LEU A  31;HIS A 125","None","1.43A","3n58D-2c46A:undetectable","3n58D-2c46A:18.95"],["4NQA_A_9CRA501_1","RETINOIC ACID RECEPTOR RXR-ALPHA","2c46","MRNA CAPPING ENZYME","Homo sapiens",5,"PHE A 156;ALA A 152;CYH A 126;HIS A 125;LEU A  67","None","1.14A","4nqaA-2c46A:undetectable","4nqaA-2c46A:21.39"]]