SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c47'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		4 / 5 LYS A 159
PHE A 171
LEU A  96
LEU A 308
 None
 1.20A 1skxA-2c47A:
undetectable		 1skxA-2c47A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		5 / 10 GLU A 120
GLY A 123
GLY A 174
LEU A 119
ALA A  73
 None
None
None
5ID  A1300 ( 4.7A)
5ID  A1300 ( 3.8A)
 1.16A 1x7pA-2c47A:
undetectable
1x7pB-2c47A:
undetectable		 1x7pA-2c47A:
21.96
1x7pB-2c47A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		5 / 12 PRO A 251
GLY A 268
ARG A 295
ALA A 273
THR A 274
 None
 1.40A 2axnA-2c47A:
undetectable		 2axnA-2c47A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		4 / 7 PHE A 130
THR A 136
LEU A 250
VAL A 142
 None
 1.02A 2cppA-2c47A:
undetectable		 2cppA-2c47A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		3 / 3 HIS A 182
ILE A 184
LEU A 122
 None
None
5ID  A1300 (-4.2A)
 0.55A 2kceA-2c47A:
undetectable		 2kceA-2c47A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		4 / 4 LEU A 122
GLY A 123
GLY A 174
THR A 178
 5ID  A1300 (-4.2A)
None
None
None
 0.81A 3si7A-2c47A:
undetectable		 3si7A-2c47A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		4 / 5 LEU A 122
GLY A 123
GLY A 174
THR A 178
 5ID  A1300 (-4.2A)
None
None
None
 0.80A 3si7C-2c47A:
undetectable
3si7D-2c47A:
undetectable		 3si7C-2c47A:
21.08
3si7D-2c47A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		4 / 5 LEU A 297
ARG A 295
ILE A 276
ARG A 292
 None
 1.41A 3ticA-2c47A:
undetectable		 3ticA-2c47A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		4 / 6 GLU A 169
PHE A 130
TYR A 218
HIS A 240
 None
 1.14A 4a97E-2c47A:
2.3		 4a97E-2c47A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		7 / 11 ALA A  73
LYS A  75
LEU A 119
GLU A 169
LEU A 172
ILE A 187
ASP A 188
 5ID  A1300 ( 3.8A)
None
5ID  A1300 ( 4.7A)
None
5ID  A1300 (-4.6A)
5ID  A1300 (-3.9A)
None
 0.96A 4iaaA-2c47A:
21.6		 4iaaA-2c47A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		6 / 11 ILE A  52
ALA A  73
LYS A  75
GLU A  89
LEU A 172
ASP A 188
 None
5ID  A1300 ( 3.8A)
None
None
5ID  A1300 (-4.6A)
None
 0.70A 4qmsA-2c47A:
23.8		 4qmsA-2c47A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		6 / 11 ILE A  52
ALA A  73
LYS A  75
LEU A 122
LEU A 172
ASP A 188
 None
5ID  A1300 ( 3.8A)
None
5ID  A1300 (-4.2A)
5ID  A1300 (-4.6A)
None
 0.75A 4qmsA-2c47A:
23.8		 4qmsA-2c47A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		5 / 10 ILE A  52
ALA A  73
LYS A  75
LEU A 121
LEU A 172
 None
5ID  A1300 ( 3.8A)
None
5ID  A1300 (-4.5A)
5ID  A1300 (-4.6A)
 0.58A 4rz7A-2c47A:
22.6		 4rz7A-2c47A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		5 / 12 GLU A  77
ILE A  74
ALA A  73
VAL A  72
PHE A  46
 None
None
5ID  A1300 ( 3.8A)
None
None
 0.96A 4u8yB-2c47A:
3.1		 4u8yB-2c47A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		5 / 12 GLU A  77
ILE A  74
ALA A  73
VAL A  72
PHE A  46
 None
None
5ID  A1300 ( 3.8A)
None
None
 0.97A 4u95B-2c47A:
2.6		 4u95B-2c47A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		3 / 3 TYR A 155
THR A 151
THR A 158
 None
 0.75A 5aoxB-2c47A:
undetectable		 5aoxB-2c47A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		3 / 3 TYR A 155
THR A 151
THR A 158
 None
 0.80A 5aoxE-2c47A:
undetectable		 5aoxE-2c47A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		4 / 8 LEU A 311
GLU A 285
ARG A 292
LEU A 143
 None
 1.12A 5dxeA-2c47A:
undetectable		 5dxeA-2c47A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		5 / 12 GLY A 239
GLU A 236
VAL A 294
ARG A 295
GLU A 277
 None
 1.32A 5f9zA-2c47A:
undetectable		 5f9zA-2c47A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		7 / 12 ALA A  73
LYS A  75
GLU A  89
LEU A 121
GLY A 123
LEU A 172
ASP A 188
 5ID  A1300 ( 3.8A)
None
None
5ID  A1300 (-4.5A)
None
5ID  A1300 (-4.6A)
None
 0.99A 5y7zB-2c47A:
21.9		 5y7zB-2c47A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM
(Homo
sapiens) 		4 / 8 LEU A 311
GLU A 285
ARG A 292
LEU A 143
 None
 1.14A 6cbzA-2c47A:
undetectable		 6cbzA-2c47A:
15.11