SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c49'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ADN  A1301 (-2.9A)
 0.27A 1bx4A-2c49A:
28.7		 1bx4A-2c49A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A 214
GLY A 216
ALA A 245
GLY A 246
ALA A 274
 ANP  A1304 (-3.4A)
ANP  A1304 (-3.4A)
ANP  A1304 (-3.5A)
ANP  A1304 (-3.2A)
ANP  A1304 (-3.1A)
 0.50A 1bx4A-2c49A:
28.8		 1bx4A-2c49A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 11 ASN A 155
LEU A 254
ALA A 151
GLY A 153
PHE A 184
 None
 1.21A 1l5rA-2c49A:
2.9		 1l5rA-2c49A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ADN  A1301 (-2.9A)
 0.30A 1liiA-2c49A:
31.5		 1liiA-2c49A:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ADN  A1301 (-2.9A)
 0.39A 1likA-2c49A:
30.9		 1likA-2c49A:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 8 TYR A 249
GLY A 267
GLY A 270
LEU A 268
SER A 220
 ANP  A1304 ( 4.7A)
None
None
None
ANP  A1304 ( 4.0A)
 1.44A 1qzzA-2c49A:
4.2		 1qzzA-2c49A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		4 / 4 THR A 111
GLY A 162
ASP A 160
ALA A  44
 ADN  A1301 (-3.1A)
MG  A1302 ( 4.4A)
MG  A1302 ( 4.1A)
ADN  A1301 ( 4.1A)
 1.14A 1sg9A-2c49A:
3.0		 1sg9A-2c49A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
GLY A  42
GLY A  43
ALA A 137
GLY A 244
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
None
None
 1.03A 2pkkA-2c49A:
39.4		 2pkkA-2c49A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
PHE A 113
GLN A 163
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.5A)
ADN  A1301 (-3.2A)
ADN  A1301 (-2.9A)
 0.77A 2pkkA-2c49A:
39.4		 2pkkA-2c49A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
PHE A 113
GLY A 244
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.5A)
None
ADN  A1301 (-2.9A)
 0.55A 2pkkA-2c49A:
39.4		 2pkkA-2c49A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ALA A  15
ASP A  17
GLY A  42
GLY A  43
ALA A 137
GLY A 244
 ADN  A1301 (-3.6A)
ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
None
None
 0.99A 2pkmA-2c49A:
39.0		 2pkmA-2c49A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		8 / 12 ALA A  15
ASP A  17
GLY A  42
GLY A  43
ASN A  47
PHE A 113
GLN A 163
ASP A 247
 ADN  A1301 (-3.6A)
ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.5A)
ADN  A1301 (-3.2A)
ADN  A1301 (-2.9A)
 0.71A 2pkmA-2c49A:
39.0		 2pkmA-2c49A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		8 / 12 ALA A  15
ASP A  17
GLY A  42
GLY A  43
ASN A  47
PHE A 113
GLY A 244
ASP A 247
 ADN  A1301 (-3.6A)
ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.5A)
None
ADN  A1301 (-2.9A)
 0.53A 2pkmA-2c49A:
39.0		 2pkmA-2c49A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A 254
ARG A 250
ILE A  52
 None
ANP  A1304 ( 4.5A)
None
 0.62A 2xn5B-2c49A:
undetectable		 2xn5B-2c49A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		4 / 8 THR A  96
GLY A  43
ALA A  46
ILE A  85
 None
ADN  A1301 (-3.3A)
None
None
 0.78A 3jusA-2c49A:
undetectable		 3jusA-2c49A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		4 / 8 THR A  96
GLY A  43
ALA A  46
ILE A  85
 None
ADN  A1301 (-3.3A)
None
None
 0.78A 3jusA-2c49A:
undetectable		 3jusA-2c49A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		4 / 8 THR A  96
GLY A  43
ALA A  46
ILE A  85
 None
ADN  A1301 (-3.3A)
None
None
 0.82A 3jusB-2c49A:
undetectable		 3jusB-2c49A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 GLU A 189
GLY A 244
ALA A  49
ASP A  17
GLY A  12
 MG  A1302 ( 4.1A)
None
None
ADN  A1301 (-2.8A)
None
 1.13A 3jzjA-2c49A:
undetectable		 3jzjA-2c49A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		3 / 3 TYR A 121
GLY A 139
ASP A 164
 None
None
ADN  A1301 (-2.9A)
 0.53A 3ou6C-2c49A:
2.7		 3ou6C-2c49A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB509_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		4 / 4 PHE A  69
THR A  96
LEU A  88
TYR A  90
 None
 1.28A 3pgyB-2c49A:
0.9		 3pgyB-2c49A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
GLY A 244
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-2.9A)
 0.59A 3uboA-2c49A:
31.7		 3uboA-2c49A:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.36A 3uboB-2c49A:
33.1		 3uboB-2c49A:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ADN  A1301 (-2.9A)
 0.34A 3uq6A-2c49A:
29.3		 3uq6A-2c49A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
GLY A 244
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
 0.49A 3uq6A-2c49A:
29.3		 3uq6A-2c49A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
ALA A  44
ASN A  47
THR A 111
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 ( 4.1A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.1A)
ADN  A1301 (-2.9A)
 1.13A 3uq6B-2c49A:
28.2		 3uq6B-2c49A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
GLY A  43
ALA A  44
ASN A  47
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.3A)
ADN  A1301 ( 4.1A)
ADN  A1301 (-3.4A)
ADN  A1301 (-2.9A)
 0.25A 3uq6B-2c49A:
28.2		 3uq6B-2c49A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
GLY A  43
ALA A  44
ASN A  47
GLY A 244
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.3A)
ADN  A1301 ( 4.1A)
ADN  A1301 (-3.4A)
None
 0.48A 3uq6B-2c49A:
28.2		 3uq6B-2c49A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ADN  A1301 (-2.9A)
 0.39A 3vaqA-2c49A:
28.9		 3vaqA-2c49A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
GLY A 244
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
 0.54A 3vaqA-2c49A:
28.9		 3vaqA-2c49A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
GLY A  43
ALA A  44
ASN A  47
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.3A)
ADN  A1301 ( 4.1A)
ADN  A1301 (-3.4A)
ADN  A1301 (-2.9A)
 0.28A 3vaqB-2c49A:
27.6		 3vaqB-2c49A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
GLY A  43
ALA A  44
ASN A  47
GLY A 244
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.3A)
ADN  A1301 ( 4.1A)
ADN  A1301 (-3.4A)
None
 0.55A 3vaqB-2c49A:
27.6		 3vaqB-2c49A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ADN  A1301 (-2.9A)
 0.32A 3vasA-2c49A:
28.9		 3vasA-2c49A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
GLY A 244
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
 0.50A 3vasA-2c49A:
28.9		 3vasA-2c49A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ADN  A1301 (-2.9A)
 0.25A 3vasB-2c49A:
20.3		 3vasB-2c49A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
GLY A 244
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
 0.47A 3vasB-2c49A:
20.3		 3vasB-2c49A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
ALA A  44
ASN A  47
THR A 111
GLY A 244
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 ( 4.1A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.1A)
None
ADN  A1301 (-2.9A)
 1.18A 4dc3A-2c49A:
27.3		 4dc3A-2c49A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
ALA A  44
ASN A  47
GLY A 244
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 ( 4.1A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-2.9A)
 0.73A 4dc3A-2c49A:
27.3		 4dc3A-2c49A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
GLY A 244
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-2.9A)
 0.63A 4dc3B-2c49A:
29.2		 4dc3B-2c49A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 SER A  86
ASP A  82
ILE A  83
ALA A  49
VAL A  50
 None
 1.05A 4dx5B-2c49A:
undetectable		 4dx5B-2c49A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.38A 4e3aA-2c49A:
33.1		 4e3aA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
THR A 243
GLY A 244
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ANP  A1304 (-4.3A)
None
ADN  A1301 (-2.9A)
 0.65A 4e3aB-2c49A:
32.8		 4e3aB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
ASN A  47
ILE A  19
THR A 111
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-3.1A)
ADN  A1301 (-2.9A)
 1.03A 4jksA-2c49A:
33.2		 4jksA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A  19
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 1.12A 4jksA-2c49A:
33.2		 4jksA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A 101
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.41A 4jksA-2c49A:
33.2		 4jksA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
ASN A  47
ILE A  19
THR A 111
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-3.1A)
ADN  A1301 (-2.9A)
 1.02A 4jksB-2c49A:
33.3		 4jksB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A  19
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 1.11A 4jksB-2c49A:
33.3		 4jksB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A 101
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.41A 4jksB-2c49A:
33.3		 4jksB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
ASN A  47
ILE A  19
THR A 111
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-3.1A)
ADN  A1301 (-2.9A)
 1.03A 4jkuA-2c49A:
33.2		 4jkuA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A  19
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 1.11A 4jkuA-2c49A:
33.2		 4jkuA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A 101
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.40A 4jkuA-2c49A:
33.2		 4jkuA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.35A 4jkuB-2c49A:
33.4		 4jkuB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
ASN A  47
ILE A  19
THR A 111
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-3.1A)
ADN  A1301 (-2.9A)
 1.03A 4k8cA-2c49A:
33.3		 4k8cA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A  19
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 1.12A 4k8cA-2c49A:
33.3		 4k8cA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A 101
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.42A 4k8cA-2c49A:
33.3		 4k8cA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
ASN A  47
ILE A  19
THR A 111
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-3.1A)
ADN  A1301 (-2.9A)
 1.05A 4k8cB-2c49A:
33.0		 4k8cB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A  19
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 1.12A 4k8cB-2c49A:
33.0		 4k8cB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A 101
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.41A 4k8cB-2c49A:
33.0		 4k8cB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_1
(SUGAR KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
ASN A  47
ILE A  19
THR A 111
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-3.1A)
ADN  A1301 (-2.9A)
 1.03A 4k8kA-2c49A:
33.3		 4k8kA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_1
(SUGAR KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A  19
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 1.12A 4k8kA-2c49A:
33.3		 4k8kA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_1
(SUGAR KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A 101
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.41A 4k8kA-2c49A:
33.3		 4k8kA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_1
(SUGAR KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
ASN A  47
ILE A  19
THR A 111
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-3.1A)
ADN  A1301 (-2.9A)
 1.02A 4k8kB-2c49A:
33.3		 4k8kB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_1
(SUGAR KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A  19
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 1.11A 4k8kB-2c49A:
33.3		 4k8kB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_1
(SUGAR KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A 101
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.41A 4k8kB-2c49A:
33.3		 4k8kB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.35A 4k8pA-2c49A:
33.3		 4k8pA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.35A 4k8pB-2c49A:
33.0		 4k8pB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.37A 4k8tA-2c49A:
33.2		 4k8tA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.37A 4k8tB-2c49A:
33.1		 4k8tB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.35A 4k93A-2c49A:
33.4		 4k93A-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.35A 4k93B-2c49A:
33.4		 4k93B-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.36A 4k9cA-2c49A:
33.5		 4k9cA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.35A 4k9cB-2c49A:
33.3		 4k9cB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.38A 4k9iA-2c49A:
33.3		 4k9iA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.38A 4k9iB-2c49A:
33.4		 4k9iB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.37A 4kadA-2c49A:
33.3		 4kadA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.34A 4kadB-2c49A:
29.0		 4kadB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
ASN A  47
ILE A  19
THR A 111
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-3.1A)
ADN  A1301 (-2.9A)
 1.03A 4kahA-2c49A:
33.3		 4kahA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A  19
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 1.11A 4kahA-2c49A:
33.3		 4kahA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A 101
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.41A 4kahA-2c49A:
33.3		 4kahA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
ASN A  47
ILE A  19
THR A 111
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-3.1A)
ADN  A1301 (-2.9A)
 1.02A 4kahB-2c49A:
33.3		 4kahB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A  19
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 1.11A 4kahB-2c49A:
33.3		 4kahB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A 101
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.42A 4kahB-2c49A:
33.3		 4kahB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
ASN A  47
ILE A  19
THR A 111
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-3.1A)
ADN  A1301 (-2.9A)
 1.02A 4kalA-2c49A:
33.3		 4kalA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A  19
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 1.11A 4kalA-2c49A:
33.3		 4kalA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A 101
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.40A 4kalA-2c49A:
33.3		 4kalA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
ASN A  47
ILE A  19
THR A 111
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-3.1A)
ADN  A1301 (-2.9A)
 1.01A 4kalB-2c49A:
33.0		 4kalB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A  19
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 1.11A 4kalB-2c49A:
33.0		 4kalB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A 101
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.41A 4kalB-2c49A:
33.0		 4kalB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
ASN A  47
ILE A  19
THR A 111
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-3.1A)
ADN  A1301 (-2.9A)
 1.04A 4kanA-2c49A:
33.2		 4kanA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A  19
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 1.13A 4kanA-2c49A:
33.2		 4kanA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A 101
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.41A 4kanA-2c49A:
33.2		 4kanA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
ASN A  47
ILE A  19
THR A 111
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-3.1A)
ADN  A1301 (-2.9A)
 1.02A 4kanB-2c49A:
33.3		 4kanB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A  19
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 1.13A 4kanB-2c49A:
33.3		 4kanB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A 101
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.41A 4kanB-2c49A:
33.3		 4kanB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
ASN A  47
ILE A  19
THR A 111
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-3.1A)
ADN  A1301 (-2.9A)
 1.04A 4kbeA-2c49A:
33.3		 4kbeA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A  19
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 1.14A 4kbeA-2c49A:
33.3		 4kbeA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A 101
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.40A 4kbeA-2c49A:
33.3		 4kbeA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
ASN A  47
ILE A  19
THR A 111
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-3.1A)
ADN  A1301 (-2.9A)
 1.02A 4kbeB-2c49A:
33.3		 4kbeB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A  19
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 1.11A 4kbeB-2c49A:
33.3		 4kbeB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A 101
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.42A 4kbeB-2c49A:
33.3		 4kbeB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
ASN A  47
ILE A  19
THR A 111
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-3.1A)
ADN  A1301 (-2.9A)
 1.04A 4lbgA-2c49A:
33.2		 4lbgA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A  19
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 1.12A 4lbgA-2c49A:
33.2		 4lbgA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A 101
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.41A 4lbgA-2c49A:
33.2		 4lbgA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
ASN A  47
ILE A  19
THR A 111
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-3.1A)
ADN  A1301 (-2.9A)
 1.03A 4lbgB-2c49A:
33.4		 4lbgB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A  19
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 1.12A 4lbgB-2c49A:
33.4		 4lbgB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A 101
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.42A 4lbgB-2c49A:
33.4		 4lbgB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.37A 4lbxA-2c49A:
33.3		 4lbxA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.37A 4lbxB-2c49A:
33.4		 4lbxB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.37A 4lc4A-2c49A:
33.3		 4lc4A-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.37A 4lc4B-2c49A:
33.1		 4lc4B-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
ASN A  47
ILE A  19
THR A 111
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-3.1A)
ADN  A1301 (-2.9A)
 1.03A 4lcaA-2c49A:
33.4		 4lcaA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A  19
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 1.11A 4lcaA-2c49A:
33.4		 4lcaA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A 101
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.43A 4lcaA-2c49A:
33.4		 4lcaA-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
ASN A  47
ILE A  19
THR A 111
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-3.1A)
ADN  A1301 (-2.9A)
 1.04A 4lcaB-2c49A:
33.0		 4lcaB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A  19
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 1.12A 4lcaB-2c49A:
33.0		 4lcaB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		7 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ILE A 101
THR A 243
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ANP  A1304 (-4.3A)
ADN  A1301 (-2.9A)
 0.42A 4lcaB-2c49A:
33.0		 4lcaB-2c49A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
GLY A  43
ASN A  47
GLY A 244
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-2.9A)
 0.66A 4n09A-2c49A:
29.7		 4n09A-2c49A:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
GLY A 244
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-2.9A)
 0.74A 4n09B-2c49A:
29.5		 4n09B-2c49A:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
GLY A 244
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-2.9A)
 0.74A 4n09C-2c49A:
29.6		 4n09C-2c49A:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
GLY A 244
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-2.9A)
 0.77A 4n09D-2c49A:
29.5		 4n09D-2c49A:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A  62
LEU A 254
ASN A 155
 None
 0.59A 4otwA-2c49A:
undetectable		 4otwA-2c49A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 9 THR A  14
ILE A 136
GLY A 139
ALA A 137
ASP A 247
 None
None
None
None
ADN  A1301 (-2.9A)
 1.12A 4qvqK-2c49A:
undetectable
4qvqL-2c49A:
undetectable		 4qvqK-2c49A:
21.02
4qvqL-2c49A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 9 THR A  14
ILE A 136
GLY A 139
ALA A 137
ASP A 247
 None
None
None
None
ADN  A1301 (-2.9A)
 1.13A 4qvqY-2c49A:
undetectable
4qvqZ-2c49A:
undetectable		 4qvqY-2c49A:
21.02
4qvqZ-2c49A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 TYR A  77
LEU A  78
GLY A  43
ALA A  15
LEU A  16
 None
None
ADN  A1301 (-3.3A)
ADN  A1301 (-3.6A)
None
 1.10A 4rrxA-2c49A:
undetectable		 4rrxA-2c49A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 TYR A  77
LEU A  78
GLY A  43
ALA A  15
LEU A  16
 None
None
ADN  A1301 (-3.3A)
ADN  A1301 (-3.6A)
None
 1.10A 4rrxB-2c49A:
undetectable		 4rrxB-2c49A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 SER A  86
ASP A  82
ILE A  83
ALA A  49
VAL A  50
 None
 1.08A 4u8yB-2c49A:
undetectable		 4u8yB-2c49A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 SER A  86
ASP A  82
ILE A  83
ALA A  49
VAL A  50
 None
 1.04A 4u95B-2c49A:
undetectable		 4u95B-2c49A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
ALA A 137
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
 1.23A 4ubeA-2c49A:
39.3		 4ubeA-2c49A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
PHE A 113
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.5A)
ADN  A1301 (-2.9A)
 0.28A 4ubeA-2c49A:
39.3		 4ubeA-2c49A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
PHE A 113
GLN A 163
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.5A)
ADN  A1301 (-3.2A)
 0.83A 4ubeA-2c49A:
39.3		 4ubeA-2c49A:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 8 ALA A  15
PRO A  97
GLY A  43
ALA A  44
GLY A  12
 ADN  A1301 (-3.6A)
None
ADN  A1301 (-3.3A)
ADN  A1301 ( 4.1A)
None
 1.49A 4zjzB-2c49A:
undetectable		 4zjzB-2c49A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		6 / 12 ASP A  17
GLY A  42
GLY A  43
ASN A  47
GLY A 244
ASP A 247
 ADN  A1301 (-2.8A)
ADN  A1301 (-3.4A)
ADN  A1301 (-3.3A)
ADN  A1301 (-3.4A)
None
ADN  A1301 (-2.9A)
 0.54A 5kb5A-2c49A:
30.5		 5kb5A-2c49A:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A 214
GLY A 216
ALA A 245
GLY A 246
ALA A 274
 ANP  A1304 (-3.4A)
ANP  A1304 (-3.4A)
ANP  A1304 (-3.5A)
ANP  A1304 (-3.2A)
ANP  A1304 (-3.1A)
 0.38A 5kb6A-2c49A:
25.4		 5kb6A-2c49A:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A 214
GLY A 216
ALA A 245
GLY A 246
ALA A 274
 ANP  A1304 (-3.4A)
ANP  A1304 (-3.4A)
ANP  A1304 (-3.5A)
ANP  A1304 (-3.2A)
ANP  A1304 (-3.1A)
 0.38A 5kb6B-2c49A:
27.4		 5kb6B-2c49A:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 251
GLY A 252
LYS A 292
GLU A 295
LEU A 297
 None
 0.90A 5nwuA-2c49A:
undetectable		 5nwuA-2c49A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		4 / 5 THR A 214
THR A  48
HIS A 135
GLY A 267
 ANP  A1304 (-3.4A)
None
None
None
 1.19A 6gbnC-2c49A:
2.4		 6gbnC-2c49A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		4 / 7 ALA A  44
GLY A  43
GLY A  51
CYH A  10
 ADN  A1301 ( 4.1A)
ADN  A1301 (-3.3A)
None
None
 0.86A 6nm4A-2c49A:
undetectable		 6nm4A-2c49A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 2c49 SUGAR KINASE MJ0406
(Methanocaldococc
us
jannaschii) 		4 / 7 ALA A 117
GLY A 116
LEU A 114
GLY A 139
 None
 0.73A 6nm4A-2c49A:
undetectable		 6nm4A-2c49A:
19.32