SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c4b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DM6_A_IMNA1401_1 (NADP-DEPENDENT LEUKOTRIENE B4 12-HYDROXYDEHYDROGEN ASE)	2c4b	BARNASE MCOEETI FUSION (Bacillus amyloliquefacien s; Ecballium elaterium; Momordica cochinchinensis)	5 / 10	TYR A 13 TYR A 24 ILE A 96 ILE A 88 TYR A 90	None	1.39A	2dm6A-2c4bA: undetectable 2dm6B-2c4bA: undetectable	2dm6A-2c4bA: 20.43 2dm6B-2c4bA: 20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YV5_B_SVRB207_1 (BASIC PHOSPHOLIPASE A2 HOMOLOG 2)	2c4b	BARNASE MCOEETI FUSION (Bacillus amyloliquefacien s; Ecballium elaterium; Momordica cochinchinensis)	4 / 6	LEU A 20 ASN A 23 PRO A 21 ARG A 110	None	1.45A	4yv5A-2c4bA: undetectable	4yv5A-2c4bA: 23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HP1_A_PPFA602_1 (HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT)	2c4b	BARNASE MCOEETI FUSION (Bacillus amyloliquefacien s; Ecballium elaterium; Momordica cochinchinensis)	4 / 6	ARG A 83 GLY A 52 ASP A 75 ASP A 54	SO4 A1161 ( 3.2A) None None None	1.31A	5hp1A-2c4bA: undetectable	5hp1A-2c4bA: 12.12

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2DM6_A_IMNA1401_1","NADP-DEPENDENT LEUKOTRIENE B4 12-HYDROXYDEHYDROGENASE;NADP-DEPENDENT LEUKOTRIENE B4 12-HYDROXYDEHYDROGENASE","2c4b","BARNASE MCOEETI FUSION","Bacillus amyloliquefaciens;Ecballium elaterium;Momordica cochinchinensis",5,"TYR A  13;TYR A  24;ILE A  96;ILE A  88;TYR A  90","None","1.39A","2dm6A-2c4bA:undetectable;2dm6B-2c4bA:undetectable","2dm6A-2c4bA:20.43;2dm6B-2c4bA:20.43"],["4YV5_B_SVRB207_1","BASIC PHOSPHOLIPASE A2 HOMOLOG 2;BASIC PHOSPHOLIPASE A2 HOMOLOG 2","2c4b","BARNASE MCOEETI FUSION","Bacillus amyloliquefaciens;Ecballium elaterium;Momordica cochinchinensis",4,"LEU A  20;ASN A  23;PRO A  21;ARG A 110","None","1.45A","4yv5A-2c4bA:undetectable","4yv5A-2c4bA:23.08"],["5HP1_A_PPFA602_1","HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT","2c4b","BARNASE MCOEETI FUSION","Bacillus amyloliquefaciens;Ecballium elaterium;Momordica cochinchinensis",4,"ARG A  83;GLY A  52;ASP A  75;ASP A  54","SO4 A1161 ( 3.2A);None;None;None","1.31A","5hp1A-2c4bA:undetectable","5hp1A-2c4bA:12.12"]]