SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c4i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 2c4i AVIDIN
(Gallus
gallus) 		5 / 7 ASN A  63
LEU A  93
TYR A 112
THR A 114
VAL A 116
 BTN  A1274 (-3.2A)
BTN  A1274 ( 4.9A)
BTN  A1274 (-4.5A)
BTN  A1274 (-3.7A)
BTN  A1274 (-4.9A)
 1.10A 2uz2A-2c4iA:
4.7		 2uz2A-2c4iA:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 2c4i AVIDIN
(Gallus
gallus) 		6 / 7 ASN A  91
LEU A  93
SER A  95
TYR A 112
THR A 114
VAL A 116
 BTN  A1274 (-3.3A)
BTN  A1274 ( 4.9A)
BTN  A1274 (-2.7A)
BTN  A1274 (-4.5A)
BTN  A1274 (-3.7A)
BTN  A1274 (-4.9A)
 0.36A 2uz2A-2c4iA:
4.7		 2uz2A-2c4iA:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 2c4i AVIDIN
(Gallus
gallus) 		5 / 7 ASN A 184
LEU A 214
TYR A 233
THR A 235
VAL A 237
 BTN  A1275 (-3.2A)
BTN  A1275 (-4.8A)
BTN  A1275 (-4.6A)
BTN  A1275 (-3.7A)
BTN  A1275 (-4.8A)
 1.10A 2uz2A-2c4iA:
4.7		 2uz2A-2c4iA:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 2c4i AVIDIN
(Gallus
gallus) 		6 / 7 ASN A 212
LEU A 214
SER A 216
TYR A 233
THR A 235
VAL A 237
 BTN  A1275 (-3.2A)
BTN  A1275 (-4.8A)
BTN  A1275 (-2.6A)
BTN  A1275 (-4.6A)
BTN  A1275 (-3.7A)
BTN  A1275 (-4.8A)
 0.36A 2uz2A-2c4iA:
4.7		 2uz2A-2c4iA:
31.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 2c4i AVIDIN
(Gallus
gallus) 		3 / 3 SER A  47
ARG A  45
GLN A 148
 None
 1.01A 2xnrA-2c4iA:
undetectable		 2xnrA-2c4iA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 2c4i AVIDIN
(Gallus
gallus) 		3 / 3 SER A 168
ARG A 166
GLN A  27
 None
 1.02A 2xnrA-2c4iA:
undetectable		 2xnrA-2c4iA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_C_CLMC221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2c4i AVIDIN
(Gallus
gallus) 		5 / 11 PHE A  24
PHE A  65
SER A  95
TYR A 112
VAL A  60
 None
None
BTN  A1274 (-2.7A)
BTN  A1274 (-4.5A)
None
 1.45A 3u9fA-2c4iA:
0.0
3u9fC-2c4iA:
0.0		 3u9fA-2c4iA:
20.55
3u9fC-2c4iA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 2c4i AVIDIN
(Gallus
gallus) 		4 / 8 ASN A 121
ASN A  14
THR A  21
TRP A  15
 None
None
None
BTN  A1274 (-3.6A)
 1.26A 4d1yA-2c4iA:
undetectable
4d1yB-2c4iA:
undetectable		 4d1yA-2c4iA:
19.34
4d1yB-2c4iA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 2c4i AVIDIN
(Gallus
gallus) 		4 / 8 ASN A 242
ASN A 269
THR A 142
TRP A 270
 None
None
None
BTN  A1275 (-3.6A)
 1.34A 4d1yA-2c4iA:
undetectable
4d1yB-2c4iA:
undetectable		 4d1yA-2c4iA:
19.34
4d1yB-2c4iA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2c4i AVIDIN
(Gallus
gallus) 		5 / 12 GLY A 140
TYR A 233
ILE A 220
GLY A 251
THR A  12
 None
BTN  A1275 (-4.6A)
None
None
None
 1.12A 4zdyA-2c4iA:
undetectable		 4zdyA-2c4iA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2c4i AVIDIN
(Gallus
gallus) 		6 / 12 GLY A 140
TYR A 233
PHE A 229
ILE A 220
GLY A 265
THR A   8
 None
BTN  A1275 (-4.6A)
None
None
None
None
 1.47A 5eskA-2c4iA:
undetectable		 5eskA-2c4iA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2c4i AVIDIN
(Gallus
gallus) 		5 / 12 GLY A 140
TYR A 233
ILE A 220
GLY A 251
THR A  12
 None
BTN  A1275 (-4.6A)
None
None
None
 1.14A 5eslA-2c4iA:
undetectable		 5eslA-2c4iA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2c4i AVIDIN
(Gallus
gallus) 		4 / 8 LEU A 128
LEU A  85
ILE A  62
THR A  40
 None
 0.98A 5ljbA-2c4iA:
undetectable		 5ljbA-2c4iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2c4i AVIDIN
(Gallus
gallus) 		4 / 8 LEU A 249
LEU A 206
ILE A 183
THR A 161
 None
 0.98A 5ljbA-2c4iA:
undetectable		 5ljbA-2c4iA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUR_A_STRA201_1
(AVIDIN)		 2c4i AVIDIN
(Gallus
gallus) 		7 / 10 TYR A 112
TRP A  15
PHE A  17
THR A  22
PHE A  24
TRP A  42
ASN A  63
 BTN  A1274 (-4.5A)
BTN  A1274 (-3.6A)
BTN  A1274 (-4.6A)
BTN  A1274 (-3.3A)
None
BTN  A1274 (-3.3A)
BTN  A1274 (-3.2A)
 0.36A 5lurA-2c4iA:
0.0		 5lurA-2c4iA:
42.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUR_A_STRA201_1
(AVIDIN)		 2c4i AVIDIN
(Gallus
gallus) 		6 / 10 TYR A 233
TRP A 270
THR A 143
PHE A 145
TRP A 163
ASN A 184
 BTN  A1275 (-4.6A)
BTN  A1275 (-3.6A)
BTN  A1275 (-3.3A)
None
BTN  A1275 (-3.3A)
BTN  A1275 (-3.2A)
 0.38A 5lurA-2c4iA:
0.0		 5lurA-2c4iA:
42.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUR_B_STRB201_1
(AVIDIN)		 2c4i AVIDIN
(Gallus
gallus) 		7 / 11 TYR A 112
TRP A  15
PHE A  17
THR A  22
PHE A  24
TRP A  42
ASN A  63
 BTN  A1274 (-4.5A)
BTN  A1274 (-3.6A)
BTN  A1274 (-4.6A)
BTN  A1274 (-3.3A)
None
BTN  A1274 (-3.3A)
BTN  A1274 (-3.2A)
 0.32A 5lurB-2c4iA:
4.4		 5lurB-2c4iA:
42.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LUR_B_STRB201_1
(AVIDIN)		 2c4i AVIDIN
(Gallus
gallus) 		6 / 11 TYR A 233
TRP A 270
THR A 143
PHE A 145
TRP A 163
ASN A 184
 BTN  A1275 (-4.6A)
BTN  A1275 (-3.6A)
BTN  A1275 (-3.3A)
None
BTN  A1275 (-3.3A)
BTN  A1275 (-3.2A)
 0.31A 5lurB-2c4iA:
4.4		 5lurB-2c4iA:
42.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUO_D_PFLD402_1
(PROTON-GATED ION
CHANNEL)		 2c4i AVIDIN
(Gallus
gallus) 		5 / 9 SER A 126
SER A  18
ILE A 256
THR A 117
THR A 114
 None
BTN  A1274 (-3.3A)
None
BTN  A1274 (-4.0A)
BTN  A1274 (-3.7A)
 1.48A 5muoA-2c4iA:
0.0
5muoB-2c4iA:
0.3
5muoC-2c4iA:
0.0
5muoD-2c4iA:
0.0
5muoE-2c4iA:
0.0		 5muoA-2c4iA:
12.92
5muoB-2c4iA:
12.92
5muoC-2c4iA:
12.92
5muoD-2c4iA:
12.92
5muoE-2c4iA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2c4i AVIDIN
(Gallus
gallus) 		3 / 3 LYS A   5
PRO A   7
LYS A  82
 None
 1.09A 5y9yA-2c4iA:
undetectable		 5y9yA-2c4iA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2c4i AVIDIN
(Gallus
gallus) 		3 / 3 ASP A  53
PHE A 150
ARG A  45
 None
 1.16A 5yw0A-2c4iA:
undetectable		 5yw0A-2c4iA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2c4i AVIDIN
(Gallus
gallus) 		3 / 3 ASP A 174
PHE A  29
ARG A 166
 None
 1.14A 5yw0A-2c4iA:
undetectable		 5yw0A-2c4iA:
23.24