SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c4k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A  22
GLN A  64
THR A  65
THR A  27
 None
 1.12A 2zj0B-2c4kA:
2.7		 2zj0B-2c4kA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A  22
GLN A  64
THR A  65
THR A  27
 None
 1.25A 2zj0C-2c4kA:
2.4		 2zj0C-2c4kA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		4 / 4 LEU A  22
GLN A  64
THR A  65
THR A  27
 None
 1.22A 2zj0D-2c4kA:
3.1		 2zj0D-2c4kA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A  22
GLN A  64
THR A  65
THR A  27
 None
 1.20A 3ce6B-2c4kA:
2.3		 3ce6B-2c4kA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A  22
GLN A  64
THR A  65
LEU A  34
 None
 1.05A 3ce6D-2c4kA:
2.7		 3ce6D-2c4kA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		4 / 5 ASN A 150
ALA A 119
LEU A 127
GLY A  94
 None
 0.94A 3dl9A-2c4kA:
undetectable		 3dl9A-2c4kA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 12 THR A 308
THR A 325
LEU A  22
ILE A  66
LEU A 289
 None
 1.06A 3gwxA-2c4kA:
0.0		 3gwxA-2c4kA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		3 / 3 ARG A 169
GLU A 164
TYR A 281
 None
 0.88A 3k37B-2c4kA:
undetectable		 3k37B-2c4kA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 12 SER A 154
PHE A 156
ILE A 331
LEU A 151
SER A 186
 None
 1.23A 3ko0A-2c4kA:
undetectable
3ko0B-2c4kA:
undetectable
3ko0C-2c4kA:
undetectable
3ko0D-2c4kA:
undetectable		 3ko0A-2c4kA:
12.83
3ko0B-2c4kA:
12.83
3ko0C-2c4kA:
12.83
3ko0D-2c4kA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 11 SER A 186
LEU A 151
SER A 154
PHE A 156
ILE A 331
 None
 1.23A 3ko0A-2c4kA:
undetectable
3ko0B-2c4kA:
undetectable
3ko0I-2c4kA:
undetectable
3ko0J-2c4kA:
undetectable		 3ko0A-2c4kA:
12.83
3ko0B-2c4kA:
12.83
3ko0I-2c4kA:
12.83
3ko0J-2c4kA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 151
SER A 154
PHE A 156
ILE A 331
SER A 186
 None
 1.24A 3ko0K-2c4kA:
undetectable
3ko0L-2c4kA:
undetectable
3ko0M-2c4kA:
undetectable
3ko0N-2c4kA:
undetectable		 3ko0K-2c4kA:
12.83
3ko0L-2c4kA:
12.83
3ko0M-2c4kA:
12.83
3ko0N-2c4kA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 12 SER A 154
PHE A 156
ILE A 331
LEU A 151
SER A 186
 None
 1.17A 3ko0M-2c4kA:
undetectable
3ko0N-2c4kA:
undetectable
3ko0O-2c4kA:
undetectable
3ko0P-2c4kA:
undetectable		 3ko0M-2c4kA:
12.83
3ko0N-2c4kA:
12.83
3ko0O-2c4kA:
12.83
3ko0P-2c4kA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 12 SER A 186
LEU A 151
SER A 154
PHE A 156
ILE A 331
 None
 1.20A 3ko0M-2c4kA:
undetectable
3ko0N-2c4kA:
undetectable
3ko0O-2c4kA:
undetectable
3ko0P-2c4kA:
undetectable		 3ko0M-2c4kA:
12.83
3ko0N-2c4kA:
12.83
3ko0O-2c4kA:
12.83
3ko0P-2c4kA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		3 / 3 ALA A 153
ARG A 152
LYS A 138
 None
 1.06A 3kp3B-2c4kA:
undetectable		 3kp3B-2c4kA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		3 / 3 SER A 154
ASP A 134
ASN A 150
 None
 0.91A 3lsfB-2c4kA:
undetectable
3lsfE-2c4kA:
undetectable		 3lsfB-2c4kA:
21.98
3lsfE-2c4kA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		3 / 3 ASP A 134
ASN A 150
SER A 154
 None
 0.96A 3lsfB-2c4kA:
undetectable
3lsfE-2c4kA:
undetectable		 3lsfB-2c4kA:
21.98
3lsfE-2c4kA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_C_P77C203_1
(PROTEIN S100-A4)		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 10 SER A 186
SER A 154
PHE A 156
ILE A 331
LEU A 151
 None
 1.21A 3m0wC-2c4kA:
undetectable
3m0wD-2c4kA:
undetectable
3m0wE-2c4kA:
undetectable
3m0wF-2c4kA:
undetectable		 3m0wC-2c4kA:
14.01
3m0wD-2c4kA:
14.01
3m0wE-2c4kA:
14.01
3m0wF-2c4kA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_H_P77H203_1
(PROTEIN S100-A4)		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 151
SER A 154
PHE A 156
ILE A 331
SER A 186
 None
 1.15A 3m0wE-2c4kA:
undetectable
3m0wF-2c4kA:
undetectable
3m0wG-2c4kA:
undetectable
3m0wH-2c4kA:
undetectable		 3m0wE-2c4kA:
14.01
3m0wF-2c4kA:
14.01
3m0wG-2c4kA:
14.01
3m0wH-2c4kA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_I_P77I203_1
(PROTEIN S100-A4)		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 151
SER A 154
PHE A 156
ILE A 331
SER A 186
 None
 1.14A 3m0wA-2c4kA:
undetectable
3m0wB-2c4kA:
undetectable
3m0wI-2c4kA:
undetectable
3m0wJ-2c4kA:
undetectable		 3m0wA-2c4kA:
14.01
3m0wB-2c4kA:
14.01
3m0wI-2c4kA:
14.01
3m0wJ-2c4kA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		4 / 6 THR A 310
SER A 102
ILE A 140
THR A  65
 None
 1.12A 3q70A-2c4kA:
undetectable		 3q70A-2c4kA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 173
ALA A 184
ALA A 180
ILE A 165
LEU A 158
 None
 1.12A 3uvvB-2c4kA:
undetectable		 3uvvB-2c4kA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		4 / 4 PRO A  97
LEU A  22
ILE A  26
ARG A  29
 None
 1.32A 3w1wA-2c4kA:
3.7		 3w1wA-2c4kA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		3 / 3 GLU A 163
TYR A 281
GLU A 304
 None
 0.81A 4ryaA-2c4kA:
undetectable		 4ryaA-2c4kA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		4 / 7 LYS A 103
ASP A 260
ILE A 288
TYR A  98
 None
 1.22A 5a06B-2c4kA:
undetectable		 5a06B-2c4kA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A  92
THR A  47
GLU A  76
PHE A  11
ILE A  96
 None
 1.42A 5iwuA-2c4kA:
undetectable		 5iwuA-2c4kA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		4 / 5 ASN A 309
ASP A 327
SER A 329
ARG A  29
 None
 1.31A 5w4zA-2c4kA:
undetectable		 5w4zA-2c4kA:
11.08