SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c4n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		 2c4n PROTEIN NAGD
(Escherichia
coli) 		5 / 12 MET A 189
CYH A   8
ILE A 250
PHE A  27
LEU A  28
 None
 1.49A 1m2zD-2c4nA:
undetectable		 1m2zD-2c4nA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2c4n PROTEIN NAGD
(Escherichia
coli) 		4 / 5 LEU A  41
GLY A 214
ALA A 185
ILE A   7
 None
 0.78A 2aohB-2c4nA:
undetectable		 2aohB-2c4nA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 2c4n PROTEIN NAGD
(Escherichia
coli) 		5 / 12 THR A 119
GLY A  91
GLY A  93
VAL A 114
ILE A 141
 None
 1.18A 2b25B-2c4nA:
2.9		 2b25B-2c4nA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 2c4n PROTEIN NAGD
(Escherichia
coli) 		5 / 12 THR A 196
ILE A 247
VAL A 244
CYH A   8
VAL A  13
 None
 1.31A 2g72B-2c4nA:
undetectable		 2g72B-2c4nA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 2c4n PROTEIN NAGD
(Escherichia
coli) 		4 / 6 SER A 225
LEU A 203
SER A 226
ASP A 228
 None
 0.96A 2j2pE-2c4nA:
undetectable
2j2pF-2c4nA:
undetectable		 2j2pE-2c4nA:
22.10
2j2pF-2c4nA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2c4n PROTEIN NAGD
(Escherichia
coli) 		6 / 12 LEU A  41
GLY A 210
VAL A   6
ILE A   3
VAL A  39
ILE A   7
 None
 1.47A 2q63A-2c4nA:
undetectable		 2q63A-2c4nA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 2c4n PROTEIN NAGD
(Escherichia
coli) 		4 / 8 ALA A  87
ASP A 112
THR A  75
ILE A 115
 None
 0.66A 3el0A-2c4nA:
undetectable		 3el0A-2c4nA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2c4n PROTEIN NAGD
(Escherichia
coli) 		4 / 6 ILE A 250
VAL A   6
LEU A  38
LEU A  28
 None
 0.92A 3kp6A-2c4nA:
undetectable
3kp6B-2c4nA:
undetectable		 3kp6A-2c4nA:
21.86
3kp6B-2c4nA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 2c4n PROTEIN NAGD
(Escherichia
coli) 		4 / 8 ALA A  24
GLU A  26
VAL A  63
PRO A  64
 None
 0.80A 4jltA-2c4nA:
undetectable		 4jltA-2c4nA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2c4n PROTEIN NAGD
(Escherichia
coli) 		4 / 4 GLY A  91
LEU A  79
PHE A  78
ILE A 141
 None
 0.90A 4xv2A-2c4nA:
undetectable		 4xv2A-2c4nA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 2c4n PROTEIN NAGD
(Escherichia
coli) 		5 / 12 GLY A 223
ASP A 201
ILE A 207
LEU A 227
LEU A 203
 None
MG  A1251 (-2.6A)
None
None
None
 1.07A 5bw4A-2c4nA:
undetectable		 5bw4A-2c4nA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 2c4n PROTEIN NAGD
(Escherichia
coli) 		5 / 12 VAL A 249
ILE A 250
ILE A   7
PHE A  27
ILE A 207
 None
 0.99A 5hw8B-2c4nA:
undetectable
5hw8F-2c4nA:
undetectable
5hw8G-2c4nA:
undetectable		 5hw8B-2c4nA:
20.31
5hw8F-2c4nA:
20.31
5hw8G-2c4nA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2c4n PROTEIN NAGD
(Escherichia
coli) 		4 / 6 GLY A 151
ASP A 201
ILE A  10
TYR A  44
 None
MG  A1251 (-2.6A)
PO4  A1253 ( 4.2A)
PO4  A1253 (-4.2A)
 1.10A 5iwuA-2c4nA:
undetectable		 5iwuA-2c4nA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 2c4n PROTEIN NAGD
(Escherichia
coli) 		4 / 8 VAL A  39
GLY A 210
LEU A 215
THR A 217
 None
 0.96A 5sxqA-2c4nA:
undetectable		 5sxqA-2c4nA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 2c4n PROTEIN NAGD
(Escherichia
coli) 		4 / 8 VAL A  39
GLY A 210
LEU A 215
THR A 217
 None
 0.93A 5sxtA-2c4nA:
undetectable		 5sxtA-2c4nA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 2c4n PROTEIN NAGD
(Escherichia
coli) 		4 / 8 VAL A  39
GLY A 210
LEU A 215
THR A 217
 None
 0.91A 5sxtB-2c4nA:
undetectable		 5sxtB-2c4nA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2c4n PROTEIN NAGD
(Escherichia
coli) 		4 / 8 VAL A  39
GLY A 210
LEU A 215
THR A 217
 None
 0.91A 5syjB-2c4nA:
undetectable		 5syjB-2c4nA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2c4n PROTEIN NAGD
(Escherichia
coli) 		5 / 12 ILE A  31
ILE A 247
PHE A  27
ALA A  25
ILE A   3
 None
 1.15A 6a5zD-2c4nA:
undetectable		 6a5zD-2c4nA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 2c4n PROTEIN NAGD
(Escherichia
coli) 		4 / 7 SER A 243
SER A 222
HIS A  16
GLY A  12
 None
None
None
MG  A1251 ( 4.6A)
 1.13A 6btxA-2c4nA:
undetectable		 6btxA-2c4nA:
20.09