SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c4t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		4 / 5 GLU A 160
ALA A 163
SER A 166
HIS A 168
 None
 1.26A 1errA-2c4tA:
undetectable
1errB-2c4tA:
undetectable		 1errA-2c4tA:
22.33
1errB-2c4tA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		5 / 10 LEU A 273
ASN A 219
VAL A 195
GLY A 204
LEU A 225
 None
 1.20A 1fkoA-2c4tA:
undetectable		 1fkoA-2c4tA:
20.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQP_A_SAMA500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		10 / 10 ASP A  16
LEU A  17
ASP A  21
SER A  23
TRP A  50
THR A  76
TYR A  77
THR A  80
PHE A 156
SER A 158
 SA8  A1299 (-2.9A)
SA8  A1299 ( 4.8A)
SA8  A1299 (-3.7A)
SA8  A1299 (-3.1A)
SA8  A1299 (-4.2A)
SA8  A1299 ( 4.7A)
None
SA8  A1299 (-4.0A)
SA8  A1299 (-3.5A)
SA8  A1299 (-2.6A)
 0.12A 1rqpA-2c4tA:
47.1		 1rqpA-2c4tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		7 / 7 ASP A 210
PHE A 213
ASN A 215
TRP A 217
PHE A 254
SER A 269
ARG A 270
 None
 0.19A 1rqpB-2c4tA:
46.7		 1rqpB-2c4tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQP_B_SAMB500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		10 / 10 ASP A  16
LEU A  17
ASP A  21
SER A  23
TRP A  50
THR A  76
TYR A  77
THR A  80
PHE A 156
SER A 158
 SA8  A1299 (-2.9A)
SA8  A1299 ( 4.8A)
SA8  A1299 (-3.7A)
SA8  A1299 (-3.1A)
SA8  A1299 (-4.2A)
SA8  A1299 ( 4.7A)
None
SA8  A1299 (-4.0A)
SA8  A1299 (-3.5A)
SA8  A1299 (-2.6A)
 0.15A 1rqpB-2c4tA:
46.7		 1rqpB-2c4tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		8 / 8 ASP A 210
PHE A 213
ASN A 215
TRP A 217
PHE A 254
SER A 269
ARG A 270
ALA A 276
 None
 0.19A 1rqpC-2c4tA:
46.4		 1rqpC-2c4tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		8 / 8 ASP A 210
PHE A 213
ASN A 215
TRP A 217
PHE A 254
SER A 269
ARG A 270
ALA A 276
 None
 0.15A 1rqpA-2c4tA:
47.1		 1rqpA-2c4tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQP_C_SAMC500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		10 / 10 ASP A  16
LEU A  17
ASP A  21
SER A  23
TRP A  50
THR A  76
TYR A  77
THR A  80
PHE A 156
SER A 158
 SA8  A1299 (-2.9A)
SA8  A1299 ( 4.8A)
SA8  A1299 (-3.7A)
SA8  A1299 (-3.1A)
SA8  A1299 (-4.2A)
SA8  A1299 ( 4.7A)
None
SA8  A1299 (-4.0A)
SA8  A1299 (-3.5A)
SA8  A1299 (-2.6A)
 0.12A 1rqpC-2c4tA:
46.4		 1rqpC-2c4tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		4 / 8 TYR A 272
GLU A 133
VAL A  60
ASP A  61
 None
 1.12A 1s3zA-2c4tA:
undetectable
1s3zB-2c4tA:
undetectable		 1s3zA-2c4tA:
17.80
1s3zB-2c4tA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		5 / 12 GLY A 231
LEU A 250
LEU A 225
GLY A 271
ALA A  99
 None
 1.06A 2bm9F-2c4tA:
undetectable		 2bm9F-2c4tA:
23.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Q6K_A_ADNA699_1
(CHLORINASE)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		4 / 7 ASP A  16
TYR A  77
PRO A  78
THR A  80
 SA8  A1299 (-2.9A)
None
SA8  A1299 (-4.4A)
SA8  A1299 (-4.0A)
 0.46A 2q6kA-2c4tA:
31.5		 2q6kA-2c4tA:
38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		8 / 8 ASP A 210
PHE A 213
ASN A 215
TRP A 217
PHE A 254
SER A 269
ARG A 270
ALA A 276
 None
 0.18A 2v7uA-2c4tA:
47.1		 2v7uA-2c4tA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7U_A_SAMA1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		9 / 9 ASP A  16
LEU A  17
ASP A  21
SER A  23
TRP A  50
THR A  76
TYR A  77
THR A  80
PHE A 156
 SA8  A1299 (-2.9A)
SA8  A1299 ( 4.8A)
SA8  A1299 (-3.7A)
SA8  A1299 (-3.1A)
SA8  A1299 (-4.2A)
SA8  A1299 ( 4.7A)
None
SA8  A1299 (-4.0A)
SA8  A1299 (-3.5A)
 0.18A 2v7uC-2c4tA:
46.9		 2v7uC-2c4tA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7U_B_SAMB1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		9 / 9 ASP A  16
LEU A  17
ASP A  21
SER A  23
TRP A  50
THR A  76
TYR A  77
THR A  80
PHE A 156
 SA8  A1299 (-2.9A)
SA8  A1299 ( 4.8A)
SA8  A1299 (-3.7A)
SA8  A1299 (-3.1A)
SA8  A1299 (-4.2A)
SA8  A1299 ( 4.7A)
None
SA8  A1299 (-4.0A)
SA8  A1299 (-3.5A)
 0.16A 2v7uA-2c4tA:
47.1		 2v7uA-2c4tA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		7 / 7 ASP A 210
PHE A 213
ASN A 215
TRP A 217
PHE A 254
SER A 269
ARG A 270
 None
 0.19A 2v7uB-2c4tA:
46.7		 2v7uB-2c4tA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7U_B_SAMB1300_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		9 / 9 ASP A  16
LEU A  17
ASP A  21
SER A  23
TRP A  50
THR A  76
TYR A  77
THR A  80
PHE A 156
 SA8  A1299 (-2.9A)
SA8  A1299 ( 4.8A)
SA8  A1299 (-3.7A)
SA8  A1299 (-3.1A)
SA8  A1299 (-4.2A)
SA8  A1299 ( 4.7A)
None
SA8  A1299 (-4.0A)
SA8  A1299 (-3.5A)
 0.19A 2v7uB-2c4tA:
46.7		 2v7uB-2c4tA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V7U_B_SAMB1300_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		9 / 9 ASP A 210
PHE A 213
ASN A 215
TRP A 217
PHE A 254
SER A 269
ARG A 270
ALA A 276
ASN A 278
 None
 0.20A 2v7uC-2c4tA:
46.9		 2v7uC-2c4tA:
99.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		5 / 12 ALA A 121
PRO A 122
VAL A 162
ASP A  16
PHE A  13
 None
None
None
SA8  A1299 (-2.9A)
None
 1.30A 2v95A-2c4tA:
undetectable		 2v95A-2c4tA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_A_ADNA501_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		4 / 4 PHE A 213
ASN A 215
PHE A 254
ASN A 278
 None
 0.39A 2zbuA-2c4tA:
30.7		 2zbuA-2c4tA:
28.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_C_ADNC503_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		4 / 4 PHE A 213
ASN A 215
PHE A 254
ASN A 278
 None
 0.41A 2zbuC-2c4tA:
30.7		 2zbuC-2c4tA:
28.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		3 / 3 PHE A 213
ASN A 215
PHE A 254
 None
 0.29A 2zbuD-2c4tA:
30.3		 2zbuD-2c4tA:
28.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		3 / 3 ARG A  64
GLU A 133
TYR A 119
 None
 0.84A 3k37B-2c4tA:
undetectable		 3k37B-2c4tA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		4 / 7 ASN A 123
ALA A 121
THR A  74
LEU A 131
 None
 0.97A 4ejgA-2c4tA:
undetectable		 4ejgA-2c4tA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		4 / 8 LEU A 126
VAL A 162
VAL A  87
TYR A 119
 None
 0.82A 4puoC-2c4tA:
undetectable		 4puoC-2c4tA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		4 / 8 LEU A 126
VAL A 162
VAL A  87
TYR A 119
 None
 0.89A 4pwdA-2c4tA:
undetectable		 4pwdA-2c4tA:
19.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5B6I_A_ADNA302_1
(FLUORINASE)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		7 / 7 ASP A  16
TRP A  50
THR A  76
TYR A  77
PRO A  78
THR A  80
SER A 158
 SA8  A1299 (-2.9A)
SA8  A1299 (-4.2A)
SA8  A1299 ( 4.7A)
None
SA8  A1299 (-4.4A)
SA8  A1299 (-4.0A)
SA8  A1299 (-2.6A)
 0.15A 5b6iA-2c4tA:
45.5		 5b6iA-2c4tA:
82.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5B6I_B_ADNB302_1
(FLUORINASE)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		6 / 6 ASP A  16
TRP A  50
THR A  76
TYR A  77
THR A  80
SER A 158
 SA8  A1299 (-2.9A)
SA8  A1299 (-4.2A)
SA8  A1299 ( 4.7A)
None
SA8  A1299 (-4.0A)
SA8  A1299 (-2.6A)
 0.15A 5b6iB-2c4tA:
43.3		 5b6iB-2c4tA:
82.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		3 / 3 LEU A 267
LEU A 250
ARG A 277
 None
 0.53A 5hnzB-2c4tA:
undetectable		 5hnzB-2c4tA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		5 / 12 LEU A 225
ILE A 230
GLY A 229
ILE A 220
VAL A 195
 None
 0.94A 6emuA-2c4tA:
2.3		 6emuA-2c4tA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		5 / 12 LEU A 225
ILE A 230
GLY A 229
ILE A 220
VAL A 195
 None
 0.92A 6emuB-2c4tA:
3.0		 6emuB-2c4tA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2c4t 5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE
(Streptomyces
cattleya) 		5 / 12 LEU A 225
ILE A 230
GLY A 229
ILE A 220
VAL A 195
 None
 0.94A 6emuC-2c4tA:
undetectable		 6emuC-2c4tA:
23.03