SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c4x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 2c4x ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 5 PHE A  11
PHE A  26
TRP A  43
GLY A  46
 None
 1.13A 2qmzA-2c4xA:
undetectable
2qmzB-2c4xA:
undetectable		 2qmzA-2c4xA:
22.74
2qmzB-2c4xA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 2c4x ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASP A  96
SER A  98
ARG A 166
 CA  A1253 (-3.5A)
None
None
 0.72A 3loqA-2c4xA:
undetectable		 3loqA-2c4xA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 2c4x ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ASP A  21
GLY A  46
ASP A  47
PHE A  11
ILE A  88
 None
 1.09A 3prsA-2c4xA:
undetectable		 3prsA-2c4xA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 2c4x ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 GLU A 218
THR A 215
GLY A 160
THR A 162
 None
 0.88A 4qwpB-2c4xA:
undetectable		 4qwpB-2c4xA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 2c4x ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 TYR A  40
THR A  54
THR A  52
 None
 0.81A 5aoxE-2c4xA:
undetectable		 5aoxE-2c4xA:
15.75