SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c5a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2c5a GDP-MANNOSE-3',
5'-EPIMERASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 199
SER A 142
ALA A 141
SER A 271
PHE A 245
 None
None
NAD  A1378 (-3.6A)
None
None
 1.14A 1dfoA-2c5aA:
undetectable		 1dfoA-2c5aA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2c5a GDP-MANNOSE-3',
5'-EPIMERASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 199
SER A 142
ALA A 141
SER A 271
PHE A 245
 None
None
NAD  A1378 (-3.6A)
None
None
 1.14A 1dfoB-2c5aA:
undetectable		 1dfoB-2c5aA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2c5a GDP-MANNOSE-3',
5'-EPIMERASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 199
SER A 142
ALA A 141
SER A 271
PHE A 245
 None
None
NAD  A1378 (-3.6A)
None
None
 1.13A 1dfoC-2c5aA:
undetectable		 1dfoC-2c5aA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2c5a GDP-MANNOSE-3',
5'-EPIMERASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 199
SER A 142
ALA A 141
SER A 271
PHE A 245
 None
None
NAD  A1378 (-3.6A)
None
None
 1.13A 1dfoD-2c5aA:
undetectable		 1dfoD-2c5aA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2c5a GDP-MANNOSE-3',
5'-EPIMERASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 199
SER A 142
ALA A 141
SER A 271
PHE A 245
 None
None
NAD  A1378 (-3.6A)
None
None
 1.16A 1eqbB-2c5aA:
undetectable		 1eqbB-2c5aA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2c5a GDP-MANNOSE-3',
5'-EPIMERASE
(Arabidopsis
thaliana) 		3 / 3 THR A 332
LEU A 329
VAL A 284
 None
 0.60A 1mz9E-2c5aA:
undetectable		 1mz9E-2c5aA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2c5a GDP-MANNOSE-3',
5'-EPIMERASE
(Arabidopsis
thaliana) 		5 / 12 GLY A  37
GLY A  36
PHE A 201
SER A  41
HIS A  42
 NAD  A1378 (-3.2A)
NAD  A1378 (-4.1A)
NAD  A1378 ( 4.7A)
None
None
 1.15A 1wg8B-2c5aA:
6.0		 1wg8B-2c5aA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 2c5a GDP-MANNOSE-3',
5'-EPIMERASE
(Arabidopsis
thaliana) 		5 / 9 THR A 259
LEU A 258
GLU A 182
ALA A 141
LEU A  98
 None
None
None
NAD  A1378 (-3.6A)
NAD  A1378 (-4.3A)
 1.24A 2azqA-2c5aA:
undetectable		 2azqA-2c5aA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 2c5a GDP-MANNOSE-3',
5'-EPIMERASE
(Arabidopsis
thaliana) 		4 / 5 ILE A  39
PHE A 139
PHE A  96
ILE A 269
 NAD  A1378 (-4.0A)
None
None
None
 1.08A 2hjhA-2c5aA:
4.0		 2hjhA-2c5aA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 2c5a GDP-MANNOSE-3',
5'-EPIMERASE
(Arabidopsis
thaliana) 		4 / 8 ILE A 135
ILE A 194
ASN A 125
ALA A  99
 None
None
None
NAD  A1378 (-3.8A)
 0.71A 2nniA-2c5aA:
undetectable		 2nniA-2c5aA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2c5a GDP-MANNOSE-3',
5'-EPIMERASE
(Arabidopsis
thaliana) 		5 / 7 GLY A  36
ASP A  58
ASP A  78
LEU A  79
ARG A  80
 NAD  A1378 (-4.1A)
NAD  A1378 (-2.8A)
NAD  A1378 ( 3.8A)
NAD  A1378 (-3.9A)
None
 0.77A 2uyqA-2c5aA:
4.0		 2uyqA-2c5aA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2c5a GDP-MANNOSE-3',
5'-EPIMERASE
(Arabidopsis
thaliana) 		5 / 7 GLY A  37
ASP A  58
ASP A  78
LEU A  79
ARG A  80
 NAD  A1378 (-3.2A)
NAD  A1378 (-2.8A)
NAD  A1378 ( 3.8A)
NAD  A1378 (-3.9A)
None
 0.81A 2uyqA-2c5aA:
4.0		 2uyqA-2c5aA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 2c5a GDP-MANNOSE-3',
5'-EPIMERASE
(Arabidopsis
thaliana) 		3 / 3 GLU A 279
GLN A 241
ARG A 304
 None
GDC  A1376 (-3.8A)
None
 0.98A 2w3bB-2c5aA:
undetectable		 2w3bB-2c5aA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2c5a GDP-MANNOSE-3',
5'-EPIMERASE
(Arabidopsis
thaliana) 		3 / 3 SER A 159
ASP A 164
ASP A 272
 None
 0.92A 3iv6C-2c5aA:
5.1		 3iv6C-2c5aA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 2c5a GDP-MANNOSE-3',
5'-EPIMERASE
(Arabidopsis
thaliana) 		3 / 3 PRO A 266
SER A 142
ASN A 268
 None
 0.84A 3lslG-2c5aA:
undetectable		 3lslG-2c5aA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 2c5a GDP-MANNOSE-3',
5'-EPIMERASE
(Arabidopsis
thaliana) 		5 / 12 GLY A  34
GLY A  36
ASP A  78
LEU A  79
ARG A  80
 NAD  A1378 ( 3.7A)
NAD  A1378 (-4.1A)
NAD  A1378 ( 3.8A)
NAD  A1378 (-3.9A)
None
 0.92A 3o7wA-2c5aA:
undetectable		 3o7wA-2c5aA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 2c5a GDP-MANNOSE-3',
5'-EPIMERASE
(Arabidopsis
thaliana) 		5 / 12 GLY A  34
GLY A  37
ASP A  78
LEU A  79
ARG A  80
 NAD  A1378 ( 3.7A)
NAD  A1378 (-3.2A)
NAD  A1378 ( 3.8A)
NAD  A1378 (-3.9A)
None
 0.87A 3o7wA-2c5aA:
undetectable		 3o7wA-2c5aA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 2c5a GDP-MANNOSE-3',
5'-EPIMERASE
(Arabidopsis
thaliana) 		4 / 5 ILE A 146
PRO A 170
LYS A 178
GLY A 175
 None
None
NAD  A1378 (-2.8A)
None
 1.05A 3tkdA-2c5aA:
undetectable		 3tkdA-2c5aA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 2c5a GDP-MANNOSE-3',
5'-EPIMERASE
(Arabidopsis
thaliana) 		4 / 8 VAL A  95
CYH A 196
ILE A 135
ILE A 127
 None
 1.02A 4afgD-2c5aA:
undetectable
4afgE-2c5aA:
undetectable		 4afgD-2c5aA:
19.63
4afgE-2c5aA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 2c5a GDP-MANNOSE-3',
5'-EPIMERASE
(Arabidopsis
thaliana) 		5 / 12 ALA A  35
GLY A  36
HIS A  42
ALA A  40
ILE A  32
 None
NAD  A1378 (-4.1A)
None
None
None
 0.89A 5kb6A-2c5aA:
6.0		 5kb6A-2c5aA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 2c5a GDP-MANNOSE-3',
5'-EPIMERASE
(Arabidopsis
thaliana) 		4 / 7 PRO A 321
ILE A 269
THR A 246
ILE A 204
 None
None
None
NAD  A1378 (-4.3A)
 0.93A 5murB-2c5aA:
undetectable		 5murB-2c5aA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2c5a GDP-MANNOSE-3',
5'-EPIMERASE
(Arabidopsis
thaliana) 		3 / 3 LYS A 225
LYS A 357
SER A 356
 GDC  A1376 (-2.7A)
FMT  A1390 (-3.0A)
GDC  A1376 (-2.7A)
 1.35A 5odiA-2c5aA:
4.4		 5odiA-2c5aA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 2c5a GDP-MANNOSE-3',
5'-EPIMERASE
(Arabidopsis
thaliana) 		4 / 8 GLU A 273
VAL A 275
GLY A 328
LEU A 329
 None
 1.00A 5syjB-2c5aA:
0.5		 5syjB-2c5aA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 2c5a GDP-MANNOSE-3',
5'-EPIMERASE
(Arabidopsis
thaliana) 		4 / 7 ARG A 200
ALA A 141
ILE A 146
ALA A 144
 None
NAD  A1378 (-3.6A)
None
GDC  A1376 ( 3.8A)
 0.95A 6ma7A-2c5aA:
undetectable		 6ma7A-2c5aA:
12.19