SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c5q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		5 / 8 TYR A  99
GLY A 101
GLY A 100
MET A 103
LEU A 102
 None
 1.16A 1qzzA-2c5qA:
undetectable		 1qzzA-2c5qA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		4 / 7 LYS A 158
LEU A 157
GLN A 156
PHE A  54
 None
None
CME  A 170 ( 4.4A)
None
 1.03A 1v55P-2c5qA:
undetectable
1v55W-2c5qA:
undetectable		 1v55P-2c5qA:
20.79
1v55W-2c5qA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 107
TYR A  66
TYR A  99
ILE A  67
 None
 1.06A 2dcfA-2c5qA:
undetectable		 2dcfA-2c5qA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 107
TYR A  66
VAL A  52
TYR A  99
ILE A  67
 None
 0.99A 2dcfA-2c5qA:
undetectable		 2dcfA-2c5qA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		4 / 7 LYS A 158
LEU A 157
GLN A 156
PHE A  54
 None
None
CME  A 170 ( 4.4A)
None
 0.95A 2dysP-2c5qA:
undetectable
2dysW-2c5qA:
undetectable		 2dysP-2c5qA:
20.79
2dysW-2c5qA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		4 / 7 LYS A 158
LEU A 157
GLN A 156
PHE A  54
 None
None
CME  A 170 ( 4.4A)
None
 0.98A 2eijP-2c5qA:
undetectable
2eijW-2c5qA:
undetectable		 2eijP-2c5qA:
20.79
2eijW-2c5qA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		4 / 8 LYS A 158
LEU A 157
GLN A 156
PHE A  54
 None
None
CME  A 170 ( 4.4A)
None
 0.98A 2eilP-2c5qA:
undetectable
2eilW-2c5qA:
undetectable		 2eilP-2c5qA:
20.79
2eilW-2c5qA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 107
TYR A  66
TYR A  99
ILE A  67
 None
 1.04A 2zm7A-2c5qA:
undetectable		 2zm7A-2c5qA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 107
TYR A  66
TYR A  99
ILE A  67
 None
 1.05A 2zmaA-2c5qA:
undetectable		 2zmaA-2c5qA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 107
TYR A  66
VAL A  52
TYR A  99
ILE A  67
 None
 1.02A 3a65A-2c5qA:
undetectable		 3a65A-2c5qA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 159
GLN A  87
ILE A  92
VAL A  77
LEU A  34
 None
 1.12A 3dzuA-2c5qA:
undetectable		 3dzuA-2c5qA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  29
GLY A 177
GLY A 181
SER A  43
ALA A 176
 EDO  A1234 ( 3.7A)
None
None
None
None
 1.06A 3kkzB-2c5qA:
undetectable		 3kkzB-2c5qA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		3 / 3 ILE A  37
VAL A 124
ARG A 128
 None
 0.74A 3p73A-2c5qA:
undetectable		 3p73A-2c5qA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		3 / 3 GLY A  47
THR A  48
ASN A  73
 None
 0.70A 3v4tD-2c5qA:
undetectable		 3v4tD-2c5qA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 175
ASP A 173
ILE A 169
SER A 162
 None
CME  A 170 ( 3.5A)
CME  A 170 ( 3.9A)
None
 0.81A 4ac9C-2c5qA:
undetectable		 4ac9C-2c5qA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 116
GLN A 167
THR A 161
ILE A 169
PHE A 118
 None
EDO  A1234 (-3.6A)
None
CME  A 170 ( 3.9A)
None
 1.41A 4c49C-2c5qA:
undetectable		 4c49C-2c5qA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 181
ASN A 179
ALA A  36
PHE A  31
ILE A 175
 None
 1.07A 4rvgA-2c5qA:
undetectable		 4rvgA-2c5qA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 118
ARG A 184
ILE A 175
ILE A 169
 None
EDO  A1234 (-2.7A)
None
CME  A 170 ( 3.9A)
 0.90A 5dzk4-2c5qA:
undetectable
5dzkg-2c5qA:
undetectable
5dzkm-2c5qA:
undetectable
5dzkn-2c5qA:
undetectable		 5dzk4-2c5qA:
10.00
5dzkg-2c5qA:
22.69
5dzkm-2c5qA:
24.15
5dzkn-2c5qA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 169
PHE A  54
ILE A  75
ALA A  49
VAL A 116
 CME  A 170 ( 3.9A)
None
None
CME  A 170 ( 3.7A)
None
 1.03A 5n0sA-2c5qA:
undetectable		 5n0sA-2c5qA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 169
PHE A  54
ILE A  75
ALA A  49
VAL A 116
 CME  A 170 ( 3.9A)
None
None
CME  A 170 ( 3.7A)
None
 0.98A 5n0tA-2c5qA:
undetectable		 5n0tA-2c5qA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 169
PHE A  54
ILE A  75
ALA A  49
VAL A 116
 CME  A 170 ( 3.9A)
None
None
CME  A 170 ( 3.7A)
None
 0.99A 5n0tB-2c5qA:
undetectable		 5n0tB-2c5qA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 169
PHE A  54
ILE A  75
ALA A  49
VAL A 116
 CME  A 170 ( 3.9A)
None
None
CME  A 170 ( 3.7A)
None
 0.99A 5n0wB-2c5qA:
undetectable		 5n0wB-2c5qA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 169
PHE A  54
ILE A  75
ALA A  49
VAL A 116
 CME  A 170 ( 3.9A)
None
None
CME  A 170 ( 3.7A)
None
 0.99A 5n0xA-2c5qA:
undetectable		 5n0xA-2c5qA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 169
PHE A  54
ILE A  75
ALA A  49
VAL A 116
 CME  A 170 ( 3.9A)
None
None
CME  A 170 ( 3.7A)
None
 0.99A 5n4iA-2c5qA:
undetectable		 5n4iA-2c5qA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 164
THR A  35
PRO A  32
 None
 0.57A 5v5zA-2c5qA:
undetectable		 5v5zA-2c5qA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2c5q RRAA-LIKE PROTEIN
YER010C
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 186
GLN A 188
ARG A 184
ILE A 169
 EDO  A1234 ( 4.7A)
CME  A 170 ( 3.3A)
EDO  A1234 (-2.7A)
CME  A 170 ( 3.9A)
 1.33A 6ef6A-2c5qA:
0.0		 6ef6A-2c5qA:
22.85