SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c5u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2c5u RNA LIGASE
(Escherichia
virus
T4) 		4 / 8 ILE A 176
PHE A 158
VAL A 181
SER A  70
 None
 0.96A 1kb9A-2c5uA:
undetectable
1kb9C-2c5uA:
1.8
1kb9D-2c5uA:
undetectable
1kb9E-2c5uA:
undetectable		 1kb9A-2c5uA:
22.65
1kb9C-2c5uA:
21.26
1kb9D-2c5uA:
20.57
1kb9E-2c5uA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 2c5u RNA LIGASE
(Escherichia
virus
T4) 		5 / 11 ILE A 217
LYS A 234
LEU A  79
ILE A  88
PRO A 214
 None
 1.10A 3a51A-2c5uA:
undetectable		 3a51A-2c5uA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 2c5u RNA LIGASE
(Escherichia
virus
T4) 		5 / 12 ILE A 217
LYS A 234
LEU A  79
ILE A  88
PRO A 214
 None
 1.13A 3a51D-2c5uA:
undetectable		 3a51D-2c5uA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 2c5u RNA LIGASE
(Escherichia
virus
T4) 		3 / 3 GLU A 352
VAL A 354
CYH A 356
 None
 0.93A 3fbxA-2c5uA:
undetectable		 3fbxA-2c5uA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2c5u RNA LIGASE
(Escherichia
virus
T4) 		5 / 12 VAL A 181
LEU A 134
ILE A 114
THR A 107
ASP A 144
 None
 0.83A 3gcsA-2c5uA:
undetectable		 3gcsA-2c5uA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 2c5u RNA LIGASE
(Escherichia
virus
T4) 		5 / 11 LEU A 274
ASP A 273
LEU A 262
ILE A 288
PHE A  77
 None
APC  A1375 ( 4.3A)
None
None
None
 1.29A 3ko0A-2c5uA:
1.6
3ko0B-2c5uA:
0.0
3ko0I-2c5uA:
1.5
3ko0J-2c5uA:
undetectable		 3ko0A-2c5uA:
14.40
3ko0B-2c5uA:
14.40
3ko0I-2c5uA:
14.40
3ko0J-2c5uA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NCQ_B_ACTB120_0
(NITROGEN REGULATORY
PROTEIN P-II
(GLNB-2))		 2c5u RNA LIGASE
(Escherichia
virus
T4) 		4 / 4 MET A 233
LYS A 234
ASP A  94
ASP A  92
 None
 1.34A 3ncqB-2c5uA:
0.0		 3ncqB-2c5uA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 2c5u RNA LIGASE
(Escherichia
virus
T4) 		5 / 12 LYS A  99
GLU A 159
VAL A 206
VAL A 230
LYS A 240
 APC  A1375 (-2.7A)
APC  A1375 (-2.9A)
None
APC  A1375 (-4.5A)
APC  A1375 (-2.7A)
 0.72A 3qwuA-2c5uA:
15.6		 3qwuA-2c5uA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 2c5u RNA LIGASE
(Escherichia
virus
T4) 		4 / 5 VAL A  25
GLY A  29
TYR A  32
ASP A 110
 None
 1.22A 3w9tB-2c5uA:
undetectable		 3w9tB-2c5uA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 2c5u RNA LIGASE
(Escherichia
virus
T4) 		4 / 5 VAL A  25
GLY A  29
TYR A  32
ASP A 110
 None
 1.21A 3w9tC-2c5uA:
undetectable		 3w9tC-2c5uA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 2c5u RNA LIGASE
(Escherichia
virus
T4) 		4 / 5 VAL A  25
GLY A  29
TYR A  32
ASP A 110
 None
 1.21A 3w9tD-2c5uA:
undetectable		 3w9tD-2c5uA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 2c5u RNA LIGASE
(Escherichia
virus
T4) 		4 / 5 VAL A  25
GLY A  29
TYR A  32
ASP A 110
 None
 1.21A 3w9tE-2c5uA:
undetectable		 3w9tE-2c5uA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 2c5u RNA LIGASE
(Escherichia
virus
T4) 		4 / 5 VAL A  25
GLY A  29
TYR A  32
ASP A 110
 None
 1.21A 3w9tG-2c5uA:
undetectable		 3w9tG-2c5uA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 2c5u RNA LIGASE
(Escherichia
virus
T4) 		4 / 8 SER A  26
SER A  28
TYR A 108
GLU A 113
 None
 1.18A 4ms4A-2c5uA:
undetectable		 4ms4A-2c5uA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 2c5u RNA LIGASE
(Escherichia
virus
T4) 		3 / 3 GLU A  81
LYS A 275
ASN A  78
 None
 0.96A 4y1dA-2c5uA:
undetectable
4y1dD-2c5uA:
undetectable		 4y1dA-2c5uA:
17.55
4y1dD-2c5uA:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2c5u RNA LIGASE
(Escherichia
virus
T4) 		3 / 3 LYS A 197
LEU A 178
ILE A 190
 None
 0.75A 5kc0A-2c5uA:
undetectable		 5kc0A-2c5uA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2c5u RNA LIGASE
(Escherichia
virus
T4) 		3 / 3 LYS A  64
LEU A   8
ILE A  68
 None
 0.83A 5kc4A-2c5uA:
undetectable		 5kc4A-2c5uA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2c5u RNA LIGASE
(Escherichia
virus
T4) 		5 / 12 PHE A  20
ARG A  33
ILE A  34
ASP A  23
ASP A  24
 None
 1.20A 6bxnA-2c5uA:
undetectable		 6bxnA-2c5uA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 2c5u RNA LIGASE
(Escherichia
virus
T4) 		5 / 11 SER A  70
LEU A 178
ALA A 150
PHE A 116
VAL A 105
 None
 1.31A 6dryA-2c5uA:
1.5		 6dryA-2c5uA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 2c5u RNA LIGASE
(Escherichia
virus
T4) 		3 / 3 ARG A 182
GLY A 187
GLU A 188
 None
 0.38A 6fgdA-2c5uA:
undetectable		 6fgdA-2c5uA:
20.87