SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c63'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 2c63 14-3-3 PROTEIN ETA
(Homo
sapiens) 		5 / 10 TYR A 131
ALA A 153
ALA A 149
ALA A 152
TYR A 154
 None
 1.08A 2r2vC-2c63A:
undetectable
2r2vF-2c63A:
undetectable
2r2vG-2c63A:
undetectable		 2r2vC-2c63A:
12.79
2r2vF-2c63A:
12.79
2r2vG-2c63A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 2c63 14-3-3 PROTEIN ETA
(Homo
sapiens) 		5 / 11 ARG A  57
LEU A  93
LEU A 101
GLY A 128
ASP A 129
 None
 1.32A 3sfuC-2c63A:
undetectable		 3sfuC-2c63A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2c63 14-3-3 PROTEIN ETA
(Homo
sapiens) 		5 / 9 SER A 161
ALA A 157
ALA A 153
GLY A 174
ASP A 129
 None
 1.05A 5d0xK-2c63A:
undetectable
5d0xL-2c63A:
undetectable		 5d0xK-2c63A:
22.05
5d0xL-2c63A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2c63 14-3-3 PROTEIN ETA
(Homo
sapiens) 		5 / 9 SER A 161
ALA A 157
ALA A 153
GLY A 174
ASP A 129
 None
 1.03A 5d0xY-2c63A:
undetectable
5d0xZ-2c63A:
undetectable		 5d0xY-2c63A:
22.05
5d0xZ-2c63A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 2c63 14-3-3 PROTEIN ETA
(Homo
sapiens) 		5 / 12 VAL A 146
LEU A 134
GLU A 148
ALA A 149
LEU A 101
 None
 1.13A 6f6iA-2c63A:
undetectable
6f6iB-2c63A:
undetectable		 6f6iA-2c63A:
14.98
6f6iB-2c63A:
15.09