SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c6r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		5 / 11 LEU A  59
VAL A 147
TYR A 179
TYR A 144
GLY A 148
 None
 1.40A 1fkpA-2c6rA:
undetectable		 1fkpA-2c6rA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		3 / 3 THR A 164
THR A 165
PRO A 163
 None
 0.83A 1i3wF-2c6rA:
undetectable		 1i3wF-2c6rA:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		5 / 10 LEU A  59
VAL A 147
TYR A 179
TYR A 144
GLY A 148
 None
 1.43A 1lw0A-2c6rA:
undetectable		 1lw0A-2c6rA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		5 / 11 LEU A  59
VAL A 147
TYR A 179
TYR A 144
GLY A 148
 None
 1.38A 1lwcA-2c6rA:
2.0		 1lwcA-2c6rA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		5 / 7 LEU A  59
VAL A 147
TYR A 179
TYR A 144
GLY A 148
 None
 1.37A 1lweA-2c6rA:
undetectable		 1lweA-2c6rA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		5 / 9 LEU A  59
VAL A 147
TYR A 179
TYR A 144
GLY A 148
 None
 1.38A 1lwfA-2c6rA:
undetectable		 1lwfA-2c6rA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		3 / 3 THR A 165
PRO A 163
THR A 164
 None
 0.85A 1mnvD-2c6rA:
undetectable		 1mnvD-2c6rA:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		3 / 3 THR A 164
THR A 165
PRO A 163
 None
 0.82A 1mnvD-2c6rA:
undetectable		 1mnvD-2c6rA:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		3 / 3 THR A 164
THR A 165
PRO A 163
 None
 0.84A 1qfiA-2c6rA:
undetectable		 1qfiA-2c6rA:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		5 / 12 ILE A 151
GLY A 148
VAL A 172
VAL A 147
LEU A  59
 None
 0.99A 1vptA-2c6rA:
undetectable		 1vptA-2c6rA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		5 / 9 LEU A  59
VAL A 147
TYR A 179
TYR A 144
GLY A 148
 None
 1.44A 1vrtA-2c6rA:
undetectable		 1vrtA-2c6rA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		5 / 10 LEU A  59
VAL A 147
TYR A 179
TYR A 144
GLY A 148
 None
 1.40A 2hnyA-2c6rA:
undetectable		 2hnyA-2c6rA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		5 / 12 GLN A  60
ALA A  96
ASP A  97
LEU A  56
SER A 110
 None
None
FE  A1207 (-2.1A)
None
None
 1.34A 2nv4B-2c6rA:
undetectable		 2nv4B-2c6rA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		4 / 5 TYR A 142
ALA A  61
TYR A 179
MET A 183
 None
 1.21A 3d91A-2c6rA:
undetectable		 3d91A-2c6rA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		5 / 12 VAL A 147
TYR A 179
TYR A 144
GLY A 148
LEU A  59
 None
 1.29A 3mecA-2c6rA:
undetectable		 3mecA-2c6rA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		4 / 5 LEU A 123
GLN A 149
THR A 146
GLU A  58
 None
 1.28A 3n58C-2c6rA:
undetectable		 3n58C-2c6rA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		3 / 3 THR A 165
PRO A 163
THR A 164
 None
 0.87A 4hivD-2c6rA:
undetectable		 4hivD-2c6rA:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		5 / 12 GLY A 112
ASP A 111
ILE A 117
ALA A  61
GLN A  60
 None
 1.34A 4wh5A-2c6rA:
undetectable		 4wh5A-2c6rA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		5 / 12 GLU A  58
LEU A  64
ALA A  61
ARG A 113
LEU A  56
 None
 1.26A 5nd4B-2c6rA:
undetectable		 5nd4B-2c6rA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 2c6r DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY
(Deinococcus
radiodurans) 		5 / 12 VAL A 206
LEU A  81
GLN A 138
VAL A 136
LEU A  85
 None
 1.22A 5ubbA-2c6rA:
undetectable		 5ubbA-2c6rA:
20.43