SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c6s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA
(Human
mastadenovirus
C) 		4 / 6 TRP A 376
LEU A 123
LEU A 466
PRO A 467
 None
 0.87A 1hz4A-2c6sA:
undetectable		 1hz4A-2c6sA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA
(Human
mastadenovirus
C) 		3 / 3 LYS A 493
ASP A  78
ASN A  74
 None
 1.15A 2bm9A-2c6sA:
undetectable		 2bm9A-2c6sA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA
(Human
mastadenovirus
C) 		4 / 6 VAL A 478
PHE A 397
PRO A 398
TRP A 376
 None
 1.30A 2q6oB-2c6sA:
undetectable		 2q6oB-2c6sA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA
(Human
mastadenovirus
C) 		4 / 7 PHE A 412
GLU A 177
SER A 176
VAL A 367
 None
 1.32A 3dqtA-2c6sA:
undetectable
3dqtB-2c6sA:
undetectable		 3dqtA-2c6sA:
20.97
3dqtB-2c6sA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA
(Human
mastadenovirus
C) 		4 / 7 SER A 176
VAL A 367
PHE A 412
GLU A 177
 None
 1.27A 3n5tA-2c6sA:
undetectable
3n5tB-2c6sA:
undetectable		 3n5tA-2c6sA:
20.91
3n5tB-2c6sA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA
(Human
mastadenovirus
C) 		4 / 7 PHE A 412
GLU A 177
SER A 176
VAL A 367
 None
 1.33A 3n61A-2c6sA:
undetectable
3n61B-2c6sA:
undetectable		 3n61A-2c6sA:
21.60
3n61B-2c6sA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA
(Human
mastadenovirus
C) 		4 / 7 PHE A 412
GLU A 177
SER A 176
VAL A 367
 None
 1.28A 4k5jA-2c6sA:
undetectable
4k5jB-2c6sA:
undetectable		 4k5jA-2c6sA:
20.95
4k5jB-2c6sA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA
(Human
mastadenovirus
C) 		5 / 12 VAL A 498
LEU A 495
GLY A 496
THR A  93
LEU A 378
 None
 1.24A 4o5fA-2c6sA:
undetectable
4o5fB-2c6sA:
undetectable		 4o5fA-2c6sA:
19.27
4o5fB-2c6sA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA
(Human
mastadenovirus
C) 		5 / 12 LEU A 378
VAL A 498
LEU A 495
GLY A 496
THR A  93
 None
 1.21A 4o5fA-2c6sA:
undetectable
4o5fB-2c6sA:
undetectable		 4o5fA-2c6sA:
19.27
4o5fB-2c6sA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA
(Human
mastadenovirus
C) 		4 / 7 PHE A 412
GLU A 177
SER A 176
VAL A 367
 None
 1.32A 5adlA-2c6sA:
undetectable
5adlB-2c6sA:
undetectable		 5adlA-2c6sA:
20.95
5adlB-2c6sA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA
(Human
mastadenovirus
C) 		5 / 12 VAL A 498
LEU A 495
GLY A 496
THR A  93
LEU A 378
 None
 1.24A 5b8hA-2c6sA:
undetectable
5b8hB-2c6sA:
undetectable		 5b8hA-2c6sA:
20.04
5b8hB-2c6sA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA
(Human
mastadenovirus
C) 		5 / 6 SER A 327
GLU A 321
GLY A 196
ARG A 197
GLY A 200
 None
 1.26A 5cdnT-2c6sA:
undetectable
5cdnU-2c6sA:
undetectable		 5cdnT-2c6sA:
21.00
5cdnU-2c6sA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA
(Human
mastadenovirus
C) 		4 / 7 PHE A 412
GLU A 177
SER A 176
VAL A 367
 None
 1.34A 5fj3A-2c6sA:
undetectable
5fj3B-2c6sA:
undetectable		 5fj3A-2c6sA:
20.95
5fj3B-2c6sA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		 2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA
(Human
mastadenovirus
C) 		5 / 9 ASP A 380
GLN A 476
GLY A 473
GLY A 474
ALA A 106
 None
 1.35A 5v3cA-2c6sA:
undetectable		 5v3cA-2c6sA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA
(Human
mastadenovirus
C) 		4 / 7 PHE A 412
GLU A 177
SER A 176
VAL A 367
 None
 1.34A 5vv7A-2c6sA:
undetectable
5vv7B-2c6sA:
undetectable		 5vv7A-2c6sA:
20.95
5vv7B-2c6sA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA
(Human
mastadenovirus
C) 		4 / 7 PHE A 412
GLU A 177
SER A 176
VAL A 367
 None
 1.36A 5vvnA-2c6sA:
undetectable
5vvnB-2c6sA:
undetectable		 5vvnA-2c6sA:
20.95
5vvnB-2c6sA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA
(Human
mastadenovirus
C) 		4 / 7 SER A 176
VAL A 367
PHE A 412
GLU A 177
 None
 1.31A 6av6A-2c6sA:
undetectable
6av6B-2c6sA:
undetectable		 6av6A-2c6sA:
11.09
6av6B-2c6sA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA
(Human
mastadenovirus
C) 		4 / 7 PHE A 412
GLU A 177
SER A 176
VAL A 367
 None
 1.33A 6av6C-2c6sA:
undetectable
6av6D-2c6sA:
undetectable		 6av6C-2c6sA:
11.09
6av6D-2c6sA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA
(Human
mastadenovirus
C) 		4 / 7 SER A 176
VAL A 367
PHE A 412
GLU A 177
 None
 1.38A 6av7A-2c6sA:
undetectable
6av7B-2c6sA:
undetectable		 6av7A-2c6sA:
11.09
6av7B-2c6sA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA
(Human
mastadenovirus
C) 		4 / 8 LEU A 242
LEU A 243
GLY A 260
LYS A 209
 None
 0.90A 6ce2A-2c6sA:
undetectable		 6ce2A-2c6sA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_A_LLLA302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA
(Human
mastadenovirus
C) 		5 / 10 GLY A 173
ASP A 366
THR A 368
THR A 180
SER A 176
 None
 1.40A 6mn1A-2c6sA:
0.0		 6mn1A-2c6sA:
9.37