SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c6x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 2c6x CITRATE SYNTHASE 1
(Bacillus
subtilis) 		5 / 11 LEU A 118
PHE A 319
VAL A  98
MET A 172
LEU A 205
 None
 1.37A 1hbpA-2c6xA:
undetectable		 1hbpA-2c6xA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 2c6x CITRATE SYNTHASE 1
(Bacillus
subtilis) 		4 / 7 TYR A 309
VAL A 272
GLU A 286
LEU A 224
 None
 1.04A 1j96B-2c6xA:
undetectable		 1j96B-2c6xA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2c6x CITRATE SYNTHASE 1
(Bacillus
subtilis) 		4 / 8 ILE A 290
PHE A 250
VAL A 220
MET A 223
 None
 1.06A 1kb9A-2c6xA:
undetectable
1kb9C-2c6xA:
undetectable
1kb9D-2c6xA:
undetectable
1kb9E-2c6xA:
undetectable		 1kb9A-2c6xA:
22.72
1kb9C-2c6xA:
20.42
1kb9D-2c6xA:
20.11
1kb9E-2c6xA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 2c6x CITRATE SYNTHASE 1
(Bacillus
subtilis) 		6 / 11 LEU A  94
ALA A 175
VAL A  98
LEU A 101
MET A 333
LEU A 118
 None
 1.13A 1rlbF-2c6xA:
undetectable		 1rlbF-2c6xA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 2c6x CITRATE SYNTHASE 1
(Bacillus
subtilis) 		4 / 7 TYR A 255
ASP A 259
TYR A  28
HIS A 178
 None
None
None
CIT  A1366 (-3.0A)
 1.46A 2bytA-2c6xA:
undetectable		 2bytA-2c6xA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 2c6x CITRATE SYNTHASE 1
(Bacillus
subtilis) 		4 / 7 TYR A 255
ASP A 259
TYR A  28
HIS A 178
 None
None
None
CIT  A1366 (-3.0A)
 1.47A 2bytD-2c6xA:
undetectable		 2bytD-2c6xA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 2c6x CITRATE SYNTHASE 1
(Bacillus
subtilis) 		4 / 5 ASP A 196
SER A 199
LEU A 101
GLY A 102
 None
 1.01A 2j2pA-2c6xA:
undetectable
2j2pB-2c6xA:
undetectable		 2j2pA-2c6xA:
18.99
2j2pB-2c6xA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 2c6x CITRATE SYNTHASE 1
(Bacillus
subtilis) 		4 / 6 ASP A 196
SER A 199
LEU A 101
GLY A 102
 None
 0.92A 2j2pA-2c6xA:
undetectable
2j2pC-2c6xA:
undetectable		 2j2pA-2c6xA:
18.99
2j2pC-2c6xA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 2c6x CITRATE SYNTHASE 1
(Bacillus
subtilis) 		4 / 6 ASP A 196
SER A 199
LEU A 101
GLY A 102
 None
 0.97A 2j2pD-2c6xA:
undetectable
2j2pF-2c6xA:
undetectable		 2j2pD-2c6xA:
18.99
2j2pF-2c6xA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 2c6x CITRATE SYNTHASE 1
(Bacillus
subtilis) 		5 / 12 VAL A 148
LEU A 168
MET A 314
PHE A 319
ALA A 127
 None
 1.29A 2jj8C-2c6xA:
undetectable		 2jj8C-2c6xA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_D_LEUD1883_0
(AMINOACYL-TRNA
SYNTHETASE)		 2c6x CITRATE SYNTHASE 1
(Bacillus
subtilis) 		4 / 5 TYR A 255
ASP A 259
TYR A  28
HIS A 178
 None
None
None
CIT  A1366 (-3.0A)
 1.47A 2v0gD-2c6xA:
0.0		 2v0gD-2c6xA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2c6x CITRATE SYNTHASE 1
(Bacillus
subtilis) 		5 / 8 LEU A 237
LEU A 247
LEU A 224
ALA A 282
PHE A 308
 None
COZ  A1365 (-4.3A)
None
None
None
 1.42A 2vcvF-2c6xA:
undetectable		 2vcvF-2c6xA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 2c6x CITRATE SYNTHASE 1
(Bacillus
subtilis) 		4 / 8 LEU A 265
LEU A 168
LYS A 165
LEU A 279
 None
 1.19A 2xn3A-2c6xA:
undetectable
2xn3B-2c6xA:
0.0		 2xn3A-2c6xA:
23.15
2xn3B-2c6xA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 2c6x CITRATE SYNTHASE 1
(Bacillus
subtilis) 		4 / 5 LEU A  26
HIS A 178
GLU A 177
HIS A 339
 None
CIT  A1366 (-3.0A)
None
None
 1.36A 4a7bB-2c6xA:
undetectable		 4a7bB-2c6xA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 2c6x CITRATE SYNTHASE 1
(Bacillus
subtilis) 		5 / 10 GLY A 335
ALA A 338
ILE A  16
ILE A  27
LEU A  26
 None
 1.09A 4dt8B-2c6xA:
undetectable		 4dt8B-2c6xA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2c6x CITRATE SYNTHASE 1
(Bacillus
subtilis) 		5 / 12 PHE A  51
GLY A  52
ILE A  49
ALA A 338
VAL A 334
 None
 1.20A 4dx5B-2c6xA:
undetectable		 4dx5B-2c6xA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2c6x CITRATE SYNTHASE 1
(Bacillus
subtilis) 		5 / 12 PHE A  51
GLY A  52
ILE A  49
ALA A 338
VAL A 334
 None
 1.16A 4u8vB-2c6xA:
undetectable		 4u8vB-2c6xA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2c6x CITRATE SYNTHASE 1
(Bacillus
subtilis) 		6 / 12 GLY A 249
GLY A 251
VAL A 220
THR A 221
ALA A 262
ALA A 310
 None
COZ  A1365 (-3.6A)
None
None
None
None
 1.28A 5kpcA-2c6xA:
undetectable		 5kpcA-2c6xA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2c6x CITRATE SYNTHASE 1
(Bacillus
subtilis) 		3 / 3 LEU A 323
ASN A 150
LEU A 168
 None
 0.59A 6exiA-2c6xA:
undetectable		 6exiA-2c6xA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 2c6x CITRATE SYNTHASE 1
(Bacillus
subtilis) 		4 / 4 LEU A  26
ASP A 259
PRO A 260
ARG A 261
 None
None
None
CIT  A1366 (-3.3A)
 1.13A 6fgdA-2c6xA:
undetectable		 6fgdA-2c6xA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2c6x CITRATE SYNTHASE 1
(Bacillus
subtilis) 		3 / 3 ARG A 291
LYS A 238
TYR A 296
 None
 1.18A 6gnaA-2c6xA:
undetectable		 6gnaA-2c6xA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2c6x CITRATE SYNTHASE 1
(Bacillus
subtilis) 		3 / 3 ARG A 291
LYS A 238
TYR A 296
 None
 1.18A 6gnbA-2c6xA:
undetectable		 6gnbA-2c6xA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_B_ACTB706_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 2c6x CITRATE SYNTHASE 1
(Bacillus
subtilis) 		4 / 5 HIS A 178
ARG A 261
PHE A 328
ARG A 332
 CIT  A1366 (-3.0A)
CIT  A1366 (-3.3A)
None
CIT  A1366 (-3.0A)
 0.99A 6hxiB-2c6xA:
13.1		 6hxiB-2c6xA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_D_ACTD703_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 2c6x CITRATE SYNTHASE 1
(Bacillus
subtilis) 		4 / 5 HIS A 178
ARG A 261
PHE A 328
ARG A 332
 CIT  A1366 (-3.0A)
CIT  A1366 (-3.3A)
None
CIT  A1366 (-3.0A)
 0.98A 6hxiD-2c6xA:
14.9		 6hxiD-2c6xA:
21.93