SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c7b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 12 GLY A  81
GLY A  82
GLY A  83
SER A 154
HIS A 281
 None
 0.40A 1dx6A-2c7bA:
18.4		 1dx6A-2c7bA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 12 GLY A  81
GLY A  83
SER A 154
PHE A 214
HIS A 281
 None
 0.96A 1dx6A-2c7bA:
18.4		 1dx6A-2c7bA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		4 / 6 PHE A 120
TYR A 218
LEU A 159
VAL A 162
 None
 1.11A 1dz4A-2c7bA:
undetectable		 1dz4A-2c7bA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 12 GLY A  82
GLY A  83
SER A 154
LEU A 210
HIS A 281
 None
 1.00A 1mx1F-2c7bA:
19.2		 1mx1F-2c7bA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		6 / 12 GLY A  81
GLY A  82
GLY A  83
SER A 154
PHE A 214
HIS A 281
 None
 0.91A 1qtiA-2c7bA:
18.6		 1qtiA-2c7bA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		4 / 8 TYR A 118
VAL A  55
ARG A  27
ASP A 126
 None
 1.09A 1s3zA-2c7bA:
undetectable
1s3zB-2c7bA:
undetectable		 1s3zA-2c7bA:
19.81
1s3zB-2c7bA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		4 / 5 PHE A 120
TYR A 218
LEU A 159
VAL A 162
 None
 1.16A 1t88B-2c7bA:
undetectable		 1t88B-2c7bA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 12 GLY A  81
GLY A  82
GLY A  83
SER A 154
HIS A 281
 None
 0.41A 1w6rA-2c7bA:
19.0		 1w6rA-2c7bA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 12 GLY A  81
GLY A  83
SER A 154
PHE A 214
HIS A 281
 None
 0.96A 1w6rA-2c7bA:
19.0		 1w6rA-2c7bA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 11 GLY A  82
GLY A  83
SER A 154
PHE A 214
HIS A 281
 None
 0.90A 1w76A-2c7bA:
17.6		 1w76A-2c7bA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 12 GLY A  83
SER A 154
LEU A 210
LEU A 195
HIS A 281
 None
 0.87A 1ya4A-2c7bA:
19.0		 1ya4A-2c7bA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		6 / 8 GLY A  81
GLY A  82
GLY A  83
SER A 154
ALA A 155
HIS A 281
 None
 0.35A 1yajC-2c7bA:
18.9		 1yajC-2c7bA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		6 / 8 GLY A  81
GLY A  82
GLY A  83
SER A 154
ALA A 155
LEU A 210
 None
 0.96A 1yajC-2c7bA:
18.9		 1yajC-2c7bA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 8 GLY A  82
GLY A  83
SER A 154
ALA A 155
HIS A 281
 None
 0.81A 1yajC-2c7bA:
18.9		 1yajC-2c7bA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		6 / 8 GLY A 156
GLY A  81
GLY A  82
SER A 154
ALA A 155
HIS A 281
 None
 1.22A 1yajC-2c7bA:
18.9		 1yajC-2c7bA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		4 / 6 LEU A  77
LEU A 166
LEU A 174
ILE A 165
 None
 0.97A 1z95A-2c7bA:
undetectable		 1z95A-2c7bA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 9 GLY A  81
GLY A  82
SER A 154
ALA A 155
HIS A 281
 None
 0.92A 2aceA-2c7bA:
19.2		 2aceA-2c7bA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		6 / 9 GLY A  82
GLY A  83
SER A 154
ALA A 155
PHE A 214
HIS A 281
 None
 0.80A 2aceA-2c7bA:
19.2		 2aceA-2c7bA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		4 / 7 PHE A 120
TYR A 218
LEU A 159
VAL A 162
 None
 1.07A 2cppA-2c7bA:
undetectable		 2cppA-2c7bA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 8 GLY A  82
GLY A  83
ALA A 155
PHE A 214
HIS A 281
 None
 0.90A 2ha4A-2c7bA:
18.8		 2ha4A-2c7bA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 7 GLY A  82
GLY A  83
ALA A 155
PHE A 214
HIS A 281
 None
 0.90A 2ha4B-2c7bA:
19.2		 2ha4B-2c7bA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		4 / 5 PHE A 120
TYR A 218
LEU A 159
VAL A 162
 None
 1.13A 2m56A-2c7bA:
undetectable		 2m56A-2c7bA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 12 ARG A  63
ILE A  95
ASP A 111
GLU A  90
ASP A  50
 None
 1.25A 2qeoA-2c7bA:
undetectable		 2qeoA-2c7bA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 10 ALA A 160
VAL A 175
ALA A 300
ILE A 304
LEU A 308
 None
 1.02A 3fl9A-2c7bA:
undetectable		 3fl9A-2c7bA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 10 ALA A 160
VAL A 175
ALA A 300
ILE A 304
LEU A 308
 None
 1.04A 3fl9F-2c7bA:
undetectable		 3fl9F-2c7bA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		4 / 6 GLU A  43
PRO A  44
ARG A  98
HIS A  94
 None
 1.41A 3ltwA-2c7bA:
undetectable		 3ltwA-2c7bA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 7 GLY A  82
GLY A  83
SER A 154
LEU A 210
HIS A 281
 None
 1.29A 3o9mA-2c7bA:
18.5		 3o9mA-2c7bA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 6 GLY A  82
GLY A  83
SER A 154
LEU A 210
HIS A 281
 None
 1.30A 3o9mB-2c7bA:
19.3		 3o9mB-2c7bA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 12 ALA A 155
GLY A 156
TYR A  79
ALA A 115
PHE A 214
 None
 1.17A 3qxyA-2c7bA:
undetectable		 3qxyA-2c7bA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 11 ALA A 155
GLY A 156
TYR A  79
ALA A 115
PHE A 214
 None
 1.20A 3qxyB-2c7bA:
undetectable
3qxyQ-2c7bA:
undetectable		 3qxyB-2c7bA:
22.29
3qxyQ-2c7bA:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		4 / 7 ILE A 304
SER A 164
LEU A 180
SER A 269
 None
 0.94A 3r9vA-2c7bA:
undetectable
3r9vB-2c7bA:
undetectable		 3r9vA-2c7bA:
22.56
3r9vB-2c7bA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		4 / 6 LEU A 259
TYR A 260
ALA A 273
LEU A 233
 None
 0.90A 3ravA-2c7bA:
undetectable		 3ravA-2c7bA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 11 ALA A 155
GLY A 156
TYR A  79
ALA A 115
PHE A 214
 None
 1.21A 3rc0A-2c7bA:
undetectable		 3rc0A-2c7bA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 12 ALA A 155
GLY A 156
TYR A  79
ALA A 115
PHE A 214
 None
 1.20A 3rc0B-2c7bA:
undetectable		 3rc0B-2c7bA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		4 / 6 LEU A 259
TYR A 260
ALA A 273
LEU A 233
 None
 0.91A 3rd0A-2c7bA:
undetectable		 3rd0A-2c7bA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 12 HIS A 281
ASP A 251
ILE A  95
GLY A  81
SER A 154
 None
 0.93A 3sueA-2c7bA:
undetectable		 3sueA-2c7bA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 12 HIS A 281
ASP A 251
ILE A  95
GLY A  81
SER A 154
 None
 0.89A 3sufB-2c7bA:
undetectable		 3sufB-2c7bA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 11 TYR A  79
GLY A 157
GLY A 257
ALA A 243
ALA A 271
 None
 1.15A 3sufC-2c7bA:
undetectable		 3sufC-2c7bA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		4 / 6 TYR A 182
GLY A 282
HIS A  92
SER A 285
 None
 1.14A 3tj7C-2c7bA:
undetectable
3tj7D-2c7bA:
undetectable		 3tj7C-2c7bA:
19.23
3tj7D-2c7bA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		4 / 6 HIS A  92
SER A 285
TYR A 182
GLY A 282
 None
 1.15A 3tj7C-2c7bA:
undetectable
3tj7D-2c7bA:
undetectable		 3tj7C-2c7bA:
19.23
3tj7D-2c7bA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 12 LEU A  26
LEU A  37
GLY A  82
PHE A  86
TYR A 182
 None
 0.70A 3uwlB-2c7bA:
undetectable		 3uwlB-2c7bA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 12 LEU A  26
LEU A  37
GLY A  82
PHE A  86
TYR A 182
 None
 0.76A 3uwlD-2c7bA:
undetectable		 3uwlD-2c7bA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 12 HIS A 281
GLY A  83
GLY A  81
TYR A 182
ALA A 115
 None
 1.12A 3vywB-2c7bA:
undetectable		 3vywB-2c7bA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 12 HIS A 281
GLY A  83
GLY A  81
TYR A 182
ALA A 115
 None
 1.09A 3vywD-2c7bA:
undetectable		 3vywD-2c7bA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 12 GLU A  90
ASP A 111
LEU A 114
ARG A  27
GLU A  31
 None
 1.17A 4cpzE-2c7bA:
undetectable		 4cpzE-2c7bA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		6 / 12 GLY A  81
GLY A  82
GLY A  83
SER A 154
PHE A 214
HIS A 281
 None
 0.89A 4ey6A-2c7bA:
3.9		 4ey6A-2c7bA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		6 / 12 GLY A  81
GLY A  82
GLY A  83
SER A 154
PHE A 214
HIS A 281
 None
 0.90A 4ey6B-2c7bA:
18.8		 4ey6B-2c7bA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 11 GLY A  82
SER A 154
TRP A 213
HIS A 281
GLY A 282
 None
 1.27A 4ey7A-2c7bA:
19.5		 4ey7A-2c7bA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 11 GLY A  82
SER A 154
TRP A 213
HIS A 281
GLY A 282
 None
 1.30A 4ey7B-2c7bA:
19.0		 4ey7B-2c7bA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		4 / 6 PHE A 120
TYR A 218
LEU A 159
VAL A 162
 None
 1.10A 4g3rB-2c7bA:
undetectable		 4g3rB-2c7bA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 12 GLY A 157
ALA A 155
THR A  91
HIS A  92
GLY A  82
 None
 0.86A 4ls7A-2c7bA:
undetectable		 4ls7A-2c7bA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		4 / 8 GLU A 256
SER A 194
PHE A 198
GLY A 199
 None
 0.81A 5flcB-2c7bA:
undetectable		 5flcB-2c7bA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		4 / 8 GLU A 256
SER A 194
PHE A 198
GLY A 199
 None
 0.81A 5flcF-2c7bA:
undetectable		 5flcF-2c7bA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 12 LEU A  26
LEU A  37
GLY A  82
PHE A  86
TYR A 182
 None
 0.78A 5j7wC-2c7bA:
undetectable		 5j7wC-2c7bA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 12 VAL A 108
ALA A 130
THR A 122
GLY A 156
LEU A 159
 None
 1.21A 5m54E-2c7bA:
3.7		 5m54E-2c7bA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		4 / 4 LEU A 308
GLY A 307
SER A 306
SER A 303
 None
 1.30A 5uunA-2c7bA:
undetectable		 5uunA-2c7bA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 12 VAL A 163
GLY A 156
GLY A 152
VAL A 150
ALA A 155
 None
 1.24A 5x7fA-2c7bA:
2.5		 5x7fA-2c7bA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		4 / 5 MET A 187
TYR A 218
GLY A  83
GLY A  82
 None
 1.12A 5x7pA-2c7bA:
undetectable		 5x7pA-2c7bA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 12 VAL A 162
VAL A 124
GLY A 215
MET A 187
GLY A  81
 None
 1.09A 6brdC-2c7bA:
undetectable		 6brdC-2c7bA:
15.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6IEY_A_CLMA401_0
(ESTERASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		6 / 11 HIS A  92
ASP A 153
LEU A 206
HIS A 281
GLY A 282
SER A 285
 None
 0.59A 6ieyA-2c7bA:
41.2
6ieyB-2c7bA:
41.3		 6ieyA-2c7bA:
41.46
6ieyB-2c7bA:
41.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 12 LEU A  26
LEU A  37
GLY A  82
PHE A  86
TYR A 182
 None
 0.87A 6qxsB-2c7bA:
undetectable		 6qxsB-2c7bA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 12 LEU A  26
LEU A  37
GLY A  82
PHE A  86
TYR A 182
 None
 0.75A 6qyaB-2c7bA:
undetectable		 6qyaB-2c7bA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 2c7b CARBOXYLESTERASE
(uncultured
archaeon) 		5 / 12 LEU A  26
LEU A  37
GLY A  82
PHE A  86
TYR A 182
 None
 0.76A 6qyaD-2c7bA:
undetectable		 6qyaD-2c7bA:
22.74