SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c7i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 2c7i PUTATIVE LIPOATE
PROTEIN LIGASE
(Thermoplasma
acidophilum) 		4 / 8 SER A  17
LEU A  86
LEU A  36
LEU A   5
 None
 0.89A 2bfpB-2c7iA:
undetectable		 2bfpB-2c7iA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2c7i PUTATIVE LIPOATE
PROTEIN LIGASE
(Thermoplasma
acidophilum) 		4 / 8 SER A  17
LEU A  86
LEU A  36
LEU A   5
 None
 0.92A 2bfpC-2c7iA:
undetectable		 2bfpC-2c7iA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 2c7i PUTATIVE LIPOATE
PROTEIN LIGASE
(Thermoplasma
acidophilum) 		4 / 8 SER A  17
LEU A  86
LEU A  36
LEU A   5
 None
 0.93A 2bfpD-2c7iA:
undetectable		 2bfpD-2c7iA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 2c7i PUTATIVE LIPOATE
PROTEIN LIGASE
(Thermoplasma
acidophilum) 		4 / 6 TRP A 160
MET A 106
MET A 102
LEU A 222
 None
 1.42A 2oz7A-2c7iA:
undetectable		 2oz7A-2c7iA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2c7i PUTATIVE LIPOATE
PROTEIN LIGASE
(Thermoplasma
acidophilum) 		5 / 10 GLY A  77
HIS A  81
THR A  74
HIS A 161
ILE A  46
 None
 1.26A 2y7wB-2c7iA:
undetectable		 2y7wB-2c7iA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 2c7i PUTATIVE LIPOATE
PROTEIN LIGASE
(Thermoplasma
acidophilum) 		5 / 10 LEU A 119
ALA A 213
ILE A 207
VAL A 203
LEU A 117
 None
 1.01A 3ogpA-2c7iA:
undetectable		 3ogpA-2c7iA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2c7i PUTATIVE LIPOATE
PROTEIN LIGASE
(Thermoplasma
acidophilum) 		3 / 3 ARG A  37
GLU A   9
THR A  10
 None
 0.76A 3v4tA-2c7iA:
undetectable		 3v4tA-2c7iA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 2c7i PUTATIVE LIPOATE
PROTEIN LIGASE
(Thermoplasma
acidophilum) 		5 / 12 LEU A  36
GLY A   3
LEU A 222
MET A 106
ILE A  24
 None
 1.46A 4p6xI-2c7iA:
undetectable		 4p6xI-2c7iA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2c7i PUTATIVE LIPOATE
PROTEIN LIGASE
(Thermoplasma
acidophilum) 		5 / 12 VAL A  57
ALA A  78
VAL A  45
GLY A  75
TYR A  49
 None
 0.88A 5igtA-2c7iA:
undetectable		 5igtA-2c7iA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 2c7i PUTATIVE LIPOATE
PROTEIN LIGASE
(Thermoplasma
acidophilum) 		5 / 12 LEU A 238
ALA A 239
ILE A  35
LEU A 159
LEU A   8
 None
 0.68A 5toaA-2c7iA:
undetectable		 5toaA-2c7iA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 2c7i PUTATIVE LIPOATE
PROTEIN LIGASE
(Thermoplasma
acidophilum) 		5 / 12 ILE A 215
SER A 206
ASN A 212
LEU A 214
LEU A 117
 None
 1.38A 6chgC-2c7iA:
undetectable		 6chgC-2c7iA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2c7i PUTATIVE LIPOATE
PROTEIN LIGASE
(Thermoplasma
acidophilum) 		3 / 3 ASP A 128
LEU A 126
ARG A 195
 None
 0.88A 7dfrA-2c7iA:
undetectable		 7dfrA-2c7iA:
20.83