SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c7s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 2c7s RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE KAPPA
(Homo
sapiens) 		4 / 6 GLN A1131
CYH A1083
VAL A 985
GLY A1091
 None
ACT  A2156 (-3.1A)
None
None
 1.17A 1ekjC-2c7sA:
undetectable
1ekjD-2c7sA:
undetectable		 1ekjC-2c7sA:
23.12
1ekjD-2c7sA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 2c7s RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE KAPPA
(Homo
sapiens) 		4 / 6 CYH A1083
VAL A 985
GLY A1091
GLN A1131
 ACT  A2156 (-3.1A)
None
None
None
 1.14A 1ekjC-2c7sA:
undetectable
1ekjD-2c7sA:
undetectable		 1ekjC-2c7sA:
23.12
1ekjD-2c7sA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2c7s RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE KAPPA
(Homo
sapiens) 		5 / 12 LEU A 930
ILE A 957
THR A 959
ASP A 969
LEU A1030
 None
 1.18A 2jn3A-2c7sA:
undetectable		 2jn3A-2c7sA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 2c7s RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE KAPPA
(Homo
sapiens) 		3 / 3 ASN A 915
ASN A 943
ARG A1122
 None
 0.77A 2rlcA-2c7sA:
undetectable		 2rlcA-2c7sA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 2c7s RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE KAPPA
(Homo
sapiens) 		5 / 12 GLY A1088
GLY A1091
GLN A1127
VAL A1126
ILE A1135
 ACT  A2156 (-3.6A)
None
ACT  A2156 (-3.4A)
None
None
 1.06A 3h52B-2c7sA:
undetectable		 3h52B-2c7sA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2c7s RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE KAPPA
(Homo
sapiens) 		5 / 12 ALA A 958
ILE A1135
GLY A1088
ILE A 947
VAL A1115
 None
None
ACT  A2156 (-3.6A)
None
None
 0.85A 4nkxA-2c7sA:
undetectable		 4nkxA-2c7sA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2c7s RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE KAPPA
(Homo
sapiens) 		6 / 12 ALA A 958
ILE A1135
GLY A1088
ALA A1117
ILE A 947
VAL A1115
 None
None
ACT  A2156 (-3.6A)
None
None
None
 1.12A 4nkxB-2c7sA:
undetectable		 4nkxB-2c7sA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 2c7s RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE KAPPA
(Homo
sapiens) 		4 / 7 ASP A1101
ASP A1097
TYR A 956
GLY A 949
 None
 0.95A 5hwaA-2c7sA:
undetectable		 5hwaA-2c7sA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 2c7s RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE KAPPA
(Homo
sapiens) 		3 / 3 VAL A1068
GLN A1043
CYH A 981
 None
 0.58A 5icxA-2c7sA:
undetectable
5icxE-2c7sA:
undetectable		 5icxA-2c7sA:
18.69
5icxE-2c7sA:
3.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 2c7s RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE KAPPA
(Homo
sapiens) 		3 / 3 VAL A1068
GLN A1043
CYH A 981
 None
 0.76A 5icxC-2c7sA:
undetectable
5icxF-2c7sA:
undetectable		 5icxC-2c7sA:
18.69
5icxF-2c7sA:
3.58