SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c7z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 2c7z 3-KETOACYL-COA
THIOLASE 2
(Arabidopsis
thaliana) 		4 / 8 ARG A 418
ALA A 348
PHE A 419
GLU A 351
 None
 1.10A 1dmiA-2c7zA:
undetectable
1dmiB-2c7zA:
undetectable		 1dmiA-2c7zA:
22.48
1dmiB-2c7zA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2c7z 3-KETOACYL-COA
THIOLASE 2
(Arabidopsis
thaliana) 		3 / 3 VAL A 403
VAL A 421
ASP A  50
 None
 0.71A 2fumD-2c7zA:
undetectable		 2fumD-2c7zA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9X_B_PXLB2503_1
(ASPARTATE
AMINOTRANSFERASE)		 2c7z 3-KETOACYL-COA
THIOLASE 2
(Arabidopsis
thaliana) 		5 / 11 GLU A 115
PRO A  75
LEU A  78
ASP A 296
LYS A 185
 None
 1.50A 2z9xB-2c7zA:
0.5		 2z9xB-2c7zA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2c7z 3-KETOACYL-COA
THIOLASE 2
(Arabidopsis
thaliana) 		4 / 4 GLY A 141
GLY A 103
GLY A 164
GLY A 396
 None
 0.58A 3bogC-2c7zA:
0.0		 3bogC-2c7zA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2c7z 3-KETOACYL-COA
THIOLASE 2
(Arabidopsis
thaliana) 		4 / 4 GLY A 141
GLY A 103
GLY A 164
GLY A 396
 None
 0.61A 3bogD-2c7zA:
undetectable		 3bogD-2c7zA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2c7z 3-KETOACYL-COA
THIOLASE 2
(Arabidopsis
thaliana) 		4 / 5 PRO A  81
VAL A  82
THR A 133
GLY A 103
 None
 1.14A 3elzB-2c7zA:
0.2		 3elzB-2c7zA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2c7z 3-KETOACYL-COA
THIOLASE 2
(Arabidopsis
thaliana) 		5 / 12 VAL A  82
LEU A 303
ILE A 100
GLY A 162
ALA A 163
 None
 1.05A 3n8zB-2c7zA:
undetectable		 3n8zB-2c7zA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2c7z 3-KETOACYL-COA
THIOLASE 2
(Arabidopsis
thaliana) 		4 / 8 ALA A 400
VAL A 403
LEU A 407
LEU A 302
 None
 0.56A 3roxA-2c7zA:
undetectable		 3roxA-2c7zA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2c7z 3-KETOACYL-COA
THIOLASE 2
(Arabidopsis
thaliana) 		5 / 11 ALA A 119
GLY A 299
ALA A 298
THR A  60
VAL A 241
 None
 0.99A 3rukD-2c7zA:
undetectable		 3rukD-2c7zA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 2c7z 3-KETOACYL-COA
THIOLASE 2
(Arabidopsis
thaliana) 		3 / 3 PHE A 186
LYS A  66
SER A  65
 None
 0.96A 3tyeB-2c7zA:
undetectable		 3tyeB-2c7zA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2c7z 3-KETOACYL-COA
THIOLASE 2
(Arabidopsis
thaliana) 		5 / 12 GLY A 297
GLY A 299
VAL A  82
PHE A  70
ASP A 261
 None
 1.03A 4a6dA-2c7zA:
undetectable		 4a6dA-2c7zA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2c7z 3-KETOACYL-COA
THIOLASE 2
(Arabidopsis
thaliana) 		5 / 12 GLY A 297
GLY A 299
VAL A  82
PHE A  70
ASP A 261
 None
 1.01A 4a6eA-2c7zA:
undetectable		 4a6eA-2c7zA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVY_B_TOYB201_1
(AMINOGLYCOSIDE
N(6')-ACETYLTRANSFER
ASE TYPE 1)		 2c7z 3-KETOACYL-COA
THIOLASE 2
(Arabidopsis
thaliana) 		5 / 10 ASN A 383
GLU A 362
ASP A 261
GLU A 237
GLY A 399
 None
 1.48A 4evyA-2c7zA:
0.0
4evyB-2c7zA:
0.2		 4evyA-2c7zA:
18.36
4evyB-2c7zA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 2c7z 3-KETOACYL-COA
THIOLASE 2
(Arabidopsis
thaliana) 		5 / 12 ALA A  41
GLN A  43
ILE A 341
ALA A 338
GLY A 336
 None
 0.99A 4r29D-2c7zA:
undetectable		 4r29D-2c7zA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 2c7z 3-KETOACYL-COA
THIOLASE 2
(Arabidopsis
thaliana) 		4 / 7 GLY A 162
GLY A 164
GLY A 299
VAL A 301
 None
 0.34A 5izjB-2c7zA:
undetectable		 5izjB-2c7zA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 2c7z 3-KETOACYL-COA
THIOLASE 2
(Arabidopsis
thaliana) 		5 / 12 SER A 221
PHE A 234
ALA A 388
THR A 398
GLU A 409
 None
 1.12A 5vcgA-2c7zA:
undetectable		 5vcgA-2c7zA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 2c7z 3-KETOACYL-COA
THIOLASE 2
(Arabidopsis
thaliana) 		4 / 7 ASP A 261
LEU A  62
ILE A 238
THR A  60
 None
 0.79A 5zsfA-2c7zA:
undetectable
5zsfB-2c7zA:
undetectable		 5zsfA-2c7zA:
11.14
5zsfB-2c7zA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2c7z 3-KETOACYL-COA
THIOLASE 2
(Arabidopsis
thaliana) 		5 / 12 THR A 257
ILE A 256
LEU A  83
PHE A  70
LEU A 165
 None
 1.37A 6a93A-2c7zA:
undetectable		 6a93A-2c7zA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 2c7z 3-KETOACYL-COA
THIOLASE 2
(Arabidopsis
thaliana) 		5 / 12 ILE A 360
VAL A 384
PHE A 368
LEU A 406
THR A 405
 None
 1.12A 6b52A-2c7zA:
undetectable		 6b52A-2c7zA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_1
(NS3 PROTEASE)		 2c7z 3-KETOACYL-COA
THIOLASE 2
(Arabidopsis
thaliana) 		5 / 9 ARG A 211
ALA A 217
VAL A 219
SER A 221
ASP A 215
 None
 1.29A 6c2mA-2c7zA:
0.0		 6c2mA-2c7zA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 2c7z 3-KETOACYL-COA
THIOLASE 2
(Arabidopsis
thaliana) 		4 / 8 ALA A 146
GLY A 141
LEU A 142
ALA A 432
 None
 0.70A 6mdqA-2c7zA:
undetectable		 6mdqA-2c7zA:
12.74