SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c8j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 2c8j FERROCHELATASE 1
(Bacillus
anthracis) 		5 / 12 VAL A   9
ILE A 296
VAL A 258
ALA A  63
LEU A   7
 None
 0.97A 1r9oA-2c8jA:
undetectable		 1r9oA-2c8jA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2c8j FERROCHELATASE 1
(Bacillus
anthracis) 		4 / 5 LEU A   8
GLY A 136
ALA A 107
ILE A 140
 None
 0.86A 2aohB-2c8jA:
undetectable		 2aohB-2c8jA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2c8j FERROCHELATASE 1
(Bacillus
anthracis) 		4 / 6 LEU A 135
VAL A 111
MET A  10
ILE A  92
 None
 1.13A 2hyyC-2c8jA:
undetectable		 2hyyC-2c8jA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2c8j FERROCHELATASE 1
(Bacillus
anthracis) 		5 / 12 SER A 117
HIS A 182
LEU A 184
PRO A 185
TRP A 229
 None
 0.92A 2po7A-2c8jA:
34.2		 2po7A-2c8jA:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2c8j FERROCHELATASE 1
(Bacillus
anthracis) 		5 / 12 SER A 117
HIS A 182
LEU A 184
PRO A 185
TRP A 229
 None
 0.94A 2po7B-2c8jA:
34.1		 2po7B-2c8jA:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 2c8j FERROCHELATASE 1
(Bacillus
anthracis) 		3 / 3 SER A 117
TYR A 116
HIS A 115
 None
 0.71A 2r2vD-2c8jA:
undetectable		 2r2vD-2c8jA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 2c8j FERROCHELATASE 1
(Bacillus
anthracis) 		4 / 6 ASP A 267
LEU A 262
TYR A 266
GLU A 271
 None
 1.03A 3w9tB-2c8jA:
undetectable		 3w9tB-2c8jA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 2c8j FERROCHELATASE 1
(Bacillus
anthracis) 		4 / 6 ASP A 267
LEU A 262
TYR A 266
GLU A 271
 None
 1.04A 3w9tE-2c8jA:
undetectable		 3w9tE-2c8jA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 2c8j FERROCHELATASE 1
(Bacillus
anthracis) 		4 / 6 ASP A 267
LEU A 262
TYR A 266
GLU A 271
 None
 1.02A 3w9tF-2c8jA:
undetectable		 3w9tF-2c8jA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 2c8j FERROCHELATASE 1
(Bacillus
anthracis) 		4 / 6 THR A  14
ARG A 127
ILE A  28
LEU A 262
 None
 1.21A 4ac9C-2c8jA:
4.2		 4ac9C-2c8jA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2c8j FERROCHELATASE 1
(Bacillus
anthracis) 		4 / 6 THR A  14
ARG A 127
ILE A  28
LEU A 262
 None
 1.21A 4acaC-2c8jA:
4.3		 4acaC-2c8jA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 2c8j FERROCHELATASE 1
(Bacillus
anthracis) 		3 / 3 ASP A 236
GLU A 278
SER A 183
 None
 0.79A 5bw4B-2c8jA:
undetectable		 5bw4B-2c8jA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 2c8j FERROCHELATASE 1
(Bacillus
anthracis) 		5 / 12 LEU A  83
ALA A 291
GLN A  62
ILE A 296
THR A  14
 None
 1.49A 5ewjC-2c8jA:
6.0
5ewjD-2c8jA:
2.6		 5ewjC-2c8jA:
22.33
5ewjD-2c8jA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2c8j FERROCHELATASE 1
(Bacillus
anthracis) 		4 / 7 VAL A  77
GLU A  76
ILE A 143
LYS A 307
 None
 1.15A 5jh7C-2c8jA:
3.5		 5jh7C-2c8jA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 2c8j FERROCHELATASE 1
(Bacillus
anthracis) 		4 / 6 LEU A 112
GLN A  62
LEU A  66
LEU A 299
 None
 1.16A 5yvnA-2c8jA:
undetectable		 5yvnA-2c8jA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2c8j FERROCHELATASE 1
(Bacillus
anthracis) 		4 / 8 ASP A  41
GLU A 271
ASP A 267
GLU A 263
 None
 1.17A 6mn4C-2c8jA:
undetectable		 6mn4C-2c8jA:
20.66