SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2c9k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		5 / 9 ILE A 541
PRO A 542
ALA A 543
ILE A 575
THR A 539
 None
 1.21A 1aj6A-2c9kA:
undetectable		 1aj6A-2c9kA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 7 THR A 300
THR A 562
GLY A 558
ASP A 565
 None
 1.03A 1bu5A-2c9kA:
undetectable		 1bu5A-2c9kA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		5 / 12 ILE A 669
PHE A 640
LEU A 606
LEU A 654
PHE A 674
 None
 1.21A 1dtlA-2c9kA:
undetectable		 1dtlA-2c9kA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 8 VAL A 426
ASN A 472
GLY A  68
LEU A 476
 None
 0.90A 1dzmA-2c9kA:
undetectable		 1dzmA-2c9kA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_A_DAHA382_1
(AMINE OXIDASE)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		5 / 10 THR A 261
TYR A 260
VAL A 252
HIS A 217
HIS A 178
 None
 1.43A 1ivvA-2c9kA:
undetectable		 1ivvA-2c9kA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_B_DAHB382_1
(AMINE OXIDASE)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		5 / 10 THR A 261
TYR A 260
VAL A 252
HIS A 217
HIS A 178
 None
 1.49A 1ivvB-2c9kA:
2.4		 1ivvB-2c9kA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		5 / 12 THR A 267
ILE A 125
ILE A 124
TYR A 202
ALA A 137
 None
 1.11A 1jtxA-2c9kA:
undetectable		 1jtxA-2c9kA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 5 TYR A 295
ARG A 296
MET A 299
THR A 300
 None
 1.11A 2eimW-2c9kA:
undetectable		 2eimW-2c9kA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 7 LEU A 476
PHE A 474
ILE A 330
ASN A 293
 None
 0.93A 2opxA-2c9kA:
undetectable		 2opxA-2c9kA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		3 / 3 GLU A 258
ASP A 314
TYR A 250
 None
 0.84A 2yvlB-2c9kA:
undetectable		 2yvlB-2c9kA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 5 ILE A 204
ARG A 296
MET A 299
THR A 300
 None
 1.27A 3abkN-2c9kA:
1.3
3abkW-2c9kA:
undetectable		 3abkN-2c9kA:
21.01
3abkW-2c9kA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 5 TYR A 295
ARG A 296
MET A 299
THR A 300
 None
 1.32A 3ag1J-2c9kA:
undetectable		 3ag1J-2c9kA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 7 PHE A 635
ASN A 629
THR A 562
LEU A 566
 None
 0.91A 3t3sC-2c9kA:
1.6		 3t3sC-2c9kA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		5 / 10 LEU A 306
VAL A  80
LEU A 218
VAL A 220
PHE A 181
 None
 1.36A 3tbgC-2c9kA:
1.9		 3tbgC-2c9kA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 6 TYR A 295
ARG A 296
MET A 299
THR A 300
 None
 1.04A 3wg7N-2c9kA:
2.1
3wg7W-2c9kA:
undetectable		 3wg7N-2c9kA:
21.01
3wg7W-2c9kA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 7 THR A 519
HIS A 383
ASN A 385
TYR A 331
 None
 1.35A 4a3uA-2c9kA:
undetectable		 4a3uA-2c9kA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 7 THR A 519
HIS A 383
ASN A 385
TYR A 331
 None
 1.34A 4a3uB-2c9kA:
undetectable		 4a3uB-2c9kA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		3 / 3 PHE A 117
VAL A 184
ILE A 140
 None
 0.60A 4emaA-2c9kA:
2.0		 4emaA-2c9kA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		3 / 3 ARG A 328
TYR A 389
ASN A 531
 None
 0.71A 4ffwB-2c9kA:
undetectable		 4ffwB-2c9kA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 7 ASN A 312
GLN A 540
GLU A 673
ARG A 589
 None
 1.36A 4mv7A-2c9kA:
undetectable		 4mv7A-2c9kA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 8 TYR A 202
ILE A 118
ASN A 138
TRP A 114
 None
 0.94A 4ou1A-2c9kA:
undetectable		 4ou1A-2c9kA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 4 ASN A 642
SER A 607
ALA A 612
VAL A 611
 None
 1.34A 4x1kC-2c9kA:
undetectable		 4x1kC-2c9kA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 5 GLU A 673
THR A 539
GLU A 325
LEU A 309
 None
 1.15A 5hm8A-2c9kA:
undetectable		 5hm8A-2c9kA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 5 GLU A 673
THR A 539
GLU A 325
LEU A 309
 None
 1.15A 5hm8B-2c9kA:
undetectable		 5hm8B-2c9kA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 5 GLU A 673
THR A 539
GLU A 325
LEU A 309
 None
 1.15A 5hm8C-2c9kA:
undetectable		 5hm8C-2c9kA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 5 GLU A 673
THR A 539
GLU A 325
LEU A 309
 None
 1.16A 5hm8D-2c9kA:
undetectable		 5hm8D-2c9kA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 5 GLU A 673
THR A 539
GLU A 325
LEU A 309
 None
 1.15A 5hm8E-2c9kA:
undetectable		 5hm8E-2c9kA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 5 GLU A 673
THR A 539
GLU A 325
LEU A 309
 None
 1.15A 5hm8F-2c9kA:
undetectable		 5hm8F-2c9kA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 5 GLU A 673
THR A 539
GLU A 325
LEU A 309
 None
 1.15A 5hm8H-2c9kA:
undetectable		 5hm8H-2c9kA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 6 VAL A 177
HIS A 180
HIS A 217
LEU A 216
 None
 1.30A 5hrqH-2c9kA:
undetectable
5hrqK-2c9kA:
undetectable
5hrqL-2c9kA:
undetectable		 5hrqH-2c9kA:
4.03
5hrqK-2c9kA:
7.77
5hrqL-2c9kA:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		5 / 12 GLY A  91
TYR A 313
SER A 144
ILE A 148
TYR A 151
 None
 1.32A 5igwA-2c9kA:
undetectable		 5igwA-2c9kA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		5 / 8 ILE A 275
LEU A 274
ILE A 125
ILE A 124
SER A 209
 None
 1.50A 5numA-2c9kA:
undetectable		 5numA-2c9kA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 7 LEU A 326
GLY A 564
THR A 562
ALA A 308
 None
 0.60A 5o96C-2c9kA:
undetectable		 5o96C-2c9kA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 5 TYR A 295
ARG A 296
MET A 299
THR A 300
 None
 1.10A 5w97J-2c9kA:
undetectable		 5w97J-2c9kA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 6 LEU A 205
TYR A  73
MET A 299
THR A 297
 None
 1.09A 5x1fA-2c9kA:
2.8
5x1fJ-2c9kA:
undetectable		 5x1fA-2c9kA:
21.01
5x1fJ-2c9kA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 5 TYR A 295
ARG A 296
MET A 299
THR A 300
 None
 1.16A 5x1fW-2c9kA:
undetectable		 5x1fW-2c9kA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 8 GLU A 455
PHE A 474
SER A 428
PHE A 520
 None
 1.02A 5y2tB-2c9kA:
undetectable		 5y2tB-2c9kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 5 GLY A 558
ASP A 565
ARG A 328
GLN A 540
 None
 0.99A 5zrfB-2c9kA:
undetectable		 5zrfB-2c9kA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA
(Bacillus
thuringiensis) 		4 / 6 LEU A 205
TYR A  73
MET A 299
THR A 297
 None
 1.08A 6nmfN-2c9kA:
2.2
6nmfW-2c9kA:
undetectable		 6nmfN-2c9kA:
21.01
6nmfW-2c9kA:
7.50