SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ca4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A
(Starkeya
novella) 		3 / 3 PHE A 154
LEU A 136
LEU A 140
 None
 0.65A 1mx1E-2ca4A:
undetectable		 1mx1E-2ca4A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A
(Starkeya
novella) 		5 / 11 ARG A 322
LEU A 316
ILE A  46
PHE A  52
GLY A 127
 None
 1.39A 2bxmA-2ca4A:
undetectable		 2bxmA-2ca4A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A
(Starkeya
novella) 		4 / 6 SER A 320
ARG A 322
PRO A 314
GLY A 315
 None
 1.42A 2y7pA-2ca4A:
undetectable		 2y7pA-2ca4A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A
(Starkeya
novella) 		4 / 8 ILE A  61
PRO A  62
TYR A  18
PRO A  19
 None
 0.90A 3em0B-2ca4A:
undetectable		 3em0B-2ca4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A
(Starkeya
novella) 		5 / 12 GLY A 119
GLY A 124
SER A 108
PHE A   8
ARG A 115
 None
 1.18A 3k13A-2ca4A:
undetectable		 3k13A-2ca4A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A
(Starkeya
novella) 		5 / 12 LEU A  89
THR A 153
ILE A 223
LEU A 140
VAL A 139
 None
 1.21A 3sp9A-2ca4A:
undetectable		 3sp9A-2ca4A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A
(Starkeya
novella) 		5 / 12 LEU A  89
THR A 153
ILE A 223
LEU A 140
VAL A 139
 None
 1.18A 3sp9B-2ca4A:
undetectable		 3sp9B-2ca4A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A
(Starkeya
novella) 		4 / 7 ARG A 260
GLY A 210
TYR A 209
SER A 105
 None
MSS  A1374 (-3.8A)
None
MSS  A1374 (-2.7A)
 0.90A 4cp3A-2ca4A:
undetectable
4cp3B-2ca4A:
undetectable		 4cp3A-2ca4A:
16.39
4cp3B-2ca4A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A
(Starkeya
novella) 		3 / 3 TYR A 186
ARG A 132
SER A 187
 None
 1.05A 4dr2I-2ca4A:
undetectable
4dr2J-2ca4A:
undetectable		 4dr2I-2ca4A:
16.80
4dr2J-2ca4A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A
(Starkeya
novella) 		4 / 7 VAL A 204
PHE A  53
GLY A 210
PHE A  52
 None
MSS  A1374 (-3.2A)
MSS  A1374 (-3.8A)
None
 0.98A 4ejjB-2ca4A:
undetectable		 4ejjB-2ca4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A
(Starkeya
novella) 		4 / 7 ASN A  91
VAL A 134
TYR A 186
ARG A 132
 None
 1.14A 4ijiH-2ca4A:
undetectable		 4ijiH-2ca4A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A
(Starkeya
novella) 		3 / 3 TYR A 186
ARG A 132
SER A 187
 None
 1.11A 4lf7I-2ca4A:
undetectable
4lf7J-2ca4A:
undetectable		 4lf7I-2ca4A:
16.80
4lf7J-2ca4A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A
(Starkeya
novella) 		3 / 3 TYR A 186
ARG A 132
SER A 187
 None
 1.11A 4lf8I-2ca4A:
undetectable
4lf8J-2ca4A:
undetectable		 4lf8I-2ca4A:
16.80
4lf8J-2ca4A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A
(Starkeya
novella) 		4 / 6 VAL A 152
LEU A 172
LEU A 136
PHE A  70
 None
 1.10A 4o1zA-2ca4A:
undetectable		 4o1zA-2ca4A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A
(Starkeya
novella) 		4 / 5 HIS A 335
VAL A 270
GLY A 273
ALA A 274
 None
 0.89A 5hwaA-2ca4A:
undetectable		 5hwaA-2ca4A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A
(Starkeya
novella) 		5 / 10 LEU A 201
GLY A 198
LEU A 184
VAL A 204
LEU A 203
 None
 1.05A 5o96G-2ca4A:
undetectable
5o96H-2ca4A:
undetectable		 5o96G-2ca4A:
24.00
5o96H-2ca4A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A
(Starkeya
novella) 		3 / 3 MET A 126
GLU A 366
ARG A 264
 None
 0.94A 5tjyA-2ca4A:
undetectable		 5tjyA-2ca4A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A
(Starkeya
novella) 		3 / 3 MET A 126
GLU A 366
ARG A 264
 None
 1.01A 5tjzA-2ca4A:
undetectable		 5tjzA-2ca4A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A
(Starkeya
novella) 		3 / 3 SER A 173
HIS A 176
TYR A 208
 None
 0.93A 5y2tA-2ca4A:
undetectable		 5y2tA-2ca4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A
(Starkeya
novella) 		3 / 3 ARG A 260
PHE A 261
GLY A 290
 None
 0.80A 6fgdA-2ca4A:
undetectable		 6fgdA-2ca4A:
22.35