SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cav'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 2cav PROTEIN (CANAVALIN)
(Canavalia
ensiformis) 		4 / 7 LEU A 265
TYR A 258
THR A 269
ASN A 299
 None
 1.04A 1afsA-2cavA:
undetectable		 1afsA-2cavA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 2cav PROTEIN (CANAVALIN)
(Canavalia
ensiformis) 		4 / 7 LEU A 265
TYR A 258
THR A 269
ASN A 299
 None
 1.03A 1afsB-2cavA:
undetectable		 1afsB-2cavA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2cav PROTEIN (CANAVALIN)
(Canavalia
ensiformis) 		3 / 3 ILE A 268
LEU A 283
VAL A 365
 None
 0.46A 1mz9B-2cavA:
undetectable		 1mz9B-2cavA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2cav PROTEIN (CANAVALIN)
(Canavalia
ensiformis) 		4 / 7 LEU A  99
PHE A 176
LEU A  67
SER A 106
 None
 0.93A 1wrlE-2cavA:
undetectable
1wrlF-2cavA:
undetectable		 1wrlE-2cavA:
11.19
1wrlF-2cavA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2cav PROTEIN (CANAVALIN)
(Canavalia
ensiformis) 		5 / 12 LEU A 283
ILE A 138
SER A 104
GLN A 275
ILE A 281
 None
 1.22A 1xotA-2cavA:
undetectable		 1xotA-2cavA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2cav PROTEIN (CANAVALIN)
(Canavalia
ensiformis) 		4 / 8 LEU A 157
ILE A 159
LEU A 119
ILE A 118
 None
 0.95A 2azxA-2cavA:
undetectable		 2azxA-2cavA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 2cav PROTEIN (CANAVALIN)
(Canavalia
ensiformis) 		5 / 9 GLY A 115
ASP A 133
ASP A 136
ILE A 149
ILE A 159
 None
 0.95A 2idwB-2cavA:
undetectable		 2idwB-2cavA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 2cav PROTEIN (CANAVALIN)
(Canavalia
ensiformis) 		5 / 12 TYR A 147
PHE A 146
ALA A 117
ILE A 149
LEU A 157
 None
 1.24A 3lcvB-2cavA:
undetectable		 3lcvB-2cavA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 2cav PROTEIN (CANAVALIN)
(Canavalia
ensiformis) 		5 / 11 LEU A  69
GLU A 173
LEU A  89
ALA A 163
SER A 106
 None
 1.02A 4wnuA-2cavA:
undetectable		 4wnuA-2cavA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2cav PROTEIN (CANAVALIN)
(Canavalia
ensiformis) 		4 / 7 HIS A 297
ILE A 348
VAL A 304
ARG A 376
 None
 1.18A 5kkzC-2cavA:
0.6
5kkzE-2cavA:
undetectable		 5kkzC-2cavA:
17.09
5kkzE-2cavA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2cav PROTEIN (CANAVALIN)
(Canavalia
ensiformis) 		4 / 7 ILE A 348
VAL A 304
ARG A 376
HIS A 297
 None
 1.19A 5kkzK-2cavA:
undetectable
5kkzQ-2cavA:
0.9		 5kkzK-2cavA:
19.88
5kkzQ-2cavA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2cav PROTEIN (CANAVALIN)
(Canavalia
ensiformis) 		4 / 7 HIS A 297
ILE A 348
VAL A 304
ARG A 376
 None
 1.19A 5kkzM-2cavA:
undetectable
5kkzO-2cavA:
undetectable		 5kkzM-2cavA:
17.09
5kkzO-2cavA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 2cav PROTEIN (CANAVALIN)
(Canavalia
ensiformis) 		5 / 9 ASN A 299
GLY A 366
ILE A 367
THR A 269
PRO A 270
 None
 1.27A 5kr2C-2cavA:
undetectable		 5kr2C-2cavA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2cav PROTEIN (CANAVALIN)
(Canavalia
ensiformis) 		5 / 12 LEU A 148
ILE A 159
GLN A 134
LEU A 283
ILE A 138
 None
 1.10A 5y2tB-2cavA:
undetectable		 5y2tB-2cavA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CB4_A_BEZA501_0
(CANAVALIN)		 2cav PROTEIN (CANAVALIN)
(Canavalia
ensiformis) 		8 / 8 ASN A 284
LEU A 286
HIS A 297
ASN A 299
VAL A 304
LEU A 306
ILE A 348
ARG A 376
 None
 0.44A 6cb4A-2cavA:
51.3		 6cb4A-2cavA:
99.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CB4_A_BEZA502_0
(CANAVALIN)		 2cav PROTEIN (CANAVALIN)
(Canavalia
ensiformis) 		4 / 4 GLY A 263
LYS A 264
GLN A 287
ASN A 289
 None
 0.86A 6cb4A-2cavA:
51.3		 6cb4A-2cavA:
99.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2cav PROTEIN (CANAVALIN)
(Canavalia
ensiformis) 		4 / 7 ALA A 137
ASP A 280
ILE A 281
ILE A 164
 None
 0.97A 6fbnA-2cavA:
undetectable		 6fbnA-2cavA:
21.44