SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cb0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Pyrococcus
furiosus) 		4 / 6 LEU A 193
GLU A 218
THR A 237
LEU A 241
 None
 0.80A 1etb2-2cb0A:
undetectable		 1etb2-2cb0A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Pyrococcus
furiosus) 		4 / 7 LEU A 319
GLU A 211
LEU A 207
GLU A 204
 None
 0.97A 1linA-2cb0A:
undetectable		 1linA-2cb0A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Pyrococcus
furiosus) 		4 / 8 LEU A 193
GLU A 218
THR A 237
LEU A 241
 None
 0.63A 1sn5C-2cb0A:
undetectable		 1sn5C-2cb0A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Pyrococcus
furiosus) 		5 / 12 ILE A  34
GLY A  85
THR A  92
VAL A  95
PHE A 142
 None
 1.01A 2okcA-2cb0A:
undetectable		 2okcA-2cb0A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Pyrococcus
furiosus) 		4 / 5 THR A 290
THR A 222
HIS A 250
LEU A 266
 None
 1.15A 3ce6A-2cb0A:
3.5		 3ce6A-2cb0A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Pyrococcus
furiosus) 		4 / 5 THR A 290
THR A 222
HIS A 250
LEU A 266
 None
 1.14A 3ce6C-2cb0A:
2.3		 3ce6C-2cb0A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Pyrococcus
furiosus) 		5 / 11 MET A  51
LEU A  48
LEU A  45
LEU A 295
GLY A 194
 None
 1.13A 3hm1B-2cb0A:
undetectable		 3hm1B-2cb0A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Pyrococcus
furiosus) 		4 / 6 LEU A  48
MET A  55
LEU A 147
ILE A 109
 None
 0.90A 4okxA-2cb0A:
undetectable		 4okxA-2cb0A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Pyrococcus
furiosus) 		4 / 7 THR A 290
THR A 222
HIS A 250
LEU A 266
 None
 1.08A 4pfjA-2cb0A:
4.2		 4pfjA-2cb0A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Pyrococcus
furiosus) 		4 / 8 ASN A 269
LEU A 266
VAL A 297
GLY A 194
 None
 0.91A 4r3aA-2cb0A:
1.5		 4r3aA-2cb0A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Pyrococcus
furiosus) 		4 / 8 ALA A 141
TYR A 143
PHE A 144
LEU A 147
 None
 0.58A 4v1fA-2cb0A:
undetectable
4v1fB-2cb0A:
undetectable		 4v1fA-2cb0A:
14.74
4v1fB-2cb0A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Pyrococcus
furiosus) 		4 / 6 PRO A 293
PHE A 144
THR A 140
ARG A 151
 None
 1.13A 4xe5A-2cb0A:
4.1		 4xe5A-2cb0A:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Pyrococcus
furiosus) 		4 / 6 PHE A 318
ARG A 317
PRO A 316
ILE A 214
 None
 1.32A 5ih0A-2cb0A:
undetectable		 5ih0A-2cb0A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Pyrococcus
furiosus) 		5 / 8 VAL A 225
ILE A 191
ALA A 219
HIS A 250
PHE A 223
 None
 1.44A 5l94A-2cb0A:
undetectable		 5l94A-2cb0A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE
(Pyrococcus
furiosus) 		4 / 6 LEU A 241
VAL A 239
THR A 237
LEU A 253
 None
 0.89A 5tudD-2cb0A:
undetectable		 5tudD-2cb0A:
23.48