SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cb1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 6 PRO A 152
HIS A 371
TRP A 203
GLU A 147
 None
None
None
PLP  A1202 ( 3.8A)
 1.44A 1ffyA-2cb1A:
0.0		 1ffyA-2cb1A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 7 ALA A 163
GLU A 160
LEU A 159
VAL A 175
 None
 0.89A 1hk2A-2cb1A:
undetectable		 1hk2A-2cb1A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 ILE A 330
LEU A 185
GLY A 180
PHE A 179
ALA A 284
 None
 1.25A 1hvyA-2cb1A:
undetectable		 1hvyA-2cb1A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 ILE A 330
LEU A 185
GLY A 180
PHE A 179
ALA A 284
 None
 1.21A 1hvyB-2cb1A:
undetectable		 1hvyB-2cb1A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 10 ILE A 330
LEU A 185
GLY A 180
PHE A 179
ALA A 284
 None
 1.47A 1ju6C-2cb1A:
undetectable		 1ju6C-2cb1A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 7 GLU A  69
LEU A 216
GLU A 198
LEU A 200
 None
 1.14A 1linA-2cb1A:
undetectable		 1linA-2cb1A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 LEU A 159
LEU A 162
LEU A 165
ALA A 166
VAL A  99
 None
 0.98A 1s9pC-2cb1A:
undetectable		 1s9pC-2cb1A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 8 THR A 332
LEU A 388
VAL A 384
GLY A 383
 None
 0.74A 2a1oA-2cb1A:
undetectable		 2a1oA-2cb1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 LEU A  88
VAL A 171
ALA A 172
LEU A 173
VAL A  99
 None
 1.06A 2c12C-2cb1A:
undetectable		 2c12C-2cb1A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 LEU A 185
GLY A 180
PHE A 179
TYR A   3
ALA A 280
 None
 1.11A 2kceB-2cb1A:
undetectable		 2kceB-2cb1A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 LEU A 185
GLY A 180
PHE A 179
VAL A 283
ALA A 280
 None
 1.12A 2kceB-2cb1A:
undetectable		 2kceB-2cb1A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 7 LEU A 185
GLY A 180
PHE A 179
TYR A   3
 None
 0.86A 2tsrA-2cb1A:
undetectable		 2tsrA-2cb1A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 9 LEU A 293
LEU A 333
LEU A 409
ALA A 408
PHE A 344
 None
 1.15A 2vcvI-2cb1A:
undetectable		 2vcvI-2cb1A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		3 / 3 ARG A  93
ARG A 142
PRO A 227
 None
 1.04A 2wljA-2cb1A:
undetectable		 2wljA-2cb1A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 GLN A 228
LEU A 222
ALA A 172
VAL A 174
LEU A 111
 None
 1.27A 3b0wB-2cb1A:
undetectable		 3b0wB-2cb1A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 LEU A 272
GLY A 212
GLY A  80
VAL A 197
LEU A 264
 None
None
PLP  A1202 (-3.0A)
None
None
 1.15A 3cjtG-2cb1A:
4.3		 3cjtG-2cb1A:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 6 PRO A 128
LEU A 104
ALA A 150
PRO A 157
 None
 0.97A 3gv1A-2cb1A:
undetectable
3gv1C-2cb1A:
undetectable		 3gv1A-2cb1A:
14.49
3gv1C-2cb1A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 6 LEU A 104
ALA A 150
PRO A 157
PRO A 128
 None
 0.95A 3gv1A-2cb1A:
undetectable
3gv1B-2cb1A:
undetectable		 3gv1A-2cb1A:
14.49
3gv1B-2cb1A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 8 LEU A 281
THR A 278
GLY A 206
ALA A 359
 None
 0.85A 3jusB-2cb1A:
undetectable		 3jusB-2cb1A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 VAL A 174
TRP A 223
ALA A  71
ALA A  87
LEU A  88
 None
 1.02A 3ln1A-2cb1A:
undetectable		 3ln1A-2cb1A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 VAL A 196
LEU A 189
ALA A  90
GLY A 213
ALA A 214
 None
 0.97A 3ln1A-2cb1A:
undetectable		 3ln1A-2cb1A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 VAL A 174
TRP A 223
ALA A  71
ALA A  87
LEU A  88
 None
 1.01A 3ln1B-2cb1A:
undetectable		 3ln1B-2cb1A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 VAL A 196
LEU A 189
ALA A  90
GLY A 213
ALA A 214
 None
 0.97A 3ln1B-2cb1A:
undetectable		 3ln1B-2cb1A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 VAL A 174
TRP A 223
ALA A  71
ALA A  87
LEU A  88
 None
 1.03A 3ln1C-2cb1A:
undetectable		 3ln1C-2cb1A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 VAL A 196
LEU A 189
ALA A  90
GLY A 213
ALA A 214
 None
 0.97A 3ln1C-2cb1A:
undetectable		 3ln1C-2cb1A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 VAL A 174
TRP A 223
ALA A  71
ALA A  87
LEU A  88
 None
 1.01A 3ln1D-2cb1A:
undetectable		 3ln1D-2cb1A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 VAL A 196
LEU A 189
ALA A  90
GLY A 213
ALA A 214
 None
 0.96A 3ln1D-2cb1A:
undetectable		 3ln1D-2cb1A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		3 / 3 GLY A 180
TRP A 203
VAL A 283
 None
 0.73A 3n62B-2cb1A:
undetectable		 3n62B-2cb1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		3 / 3 GLY A 180
TRP A 203
VAL A 283
 None
 0.75A 3n65B-2cb1A:
undetectable		 3n65B-2cb1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		3 / 3 GLY A 180
TRP A 203
VAL A 283
 None
 0.73A 3n66B-2cb1A:
undetectable		 3n66B-2cb1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 GLY A 387
GLY A 336
ASP A 334
GLU A 339
ALA A 341
 None
 1.20A 3t7sA-2cb1A:
2.0		 3t7sA-2cb1A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 GLY A 387
GLY A 336
ASP A 334
GLU A 339
ALA A 341
 None
 1.19A 3t7sB-2cb1A:
undetectable		 3t7sB-2cb1A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 GLY A 387
GLY A 336
ASP A 334
GLU A 339
ALA A 341
 None
 1.19A 3t7sD-2cb1A:
2.2		 3t7sD-2cb1A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 8 VAL A 389
LEU A 333
LEU A 335
ILE A 348
 None
 0.89A 3u5kA-2cb1A:
undetectable		 3u5kA-2cb1A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 7 VAL A 389
LEU A 333
LEU A 335
ILE A 348
 None
 0.98A 3u5kB-2cb1A:
undetectable		 3u5kB-2cb1A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 5 VAL A 389
LEU A 333
LEU A 335
ILE A 348
 None
 0.95A 4a9jA-2cb1A:
undetectable		 4a9jA-2cb1A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 5 VAL A 389
LEU A 333
LEU A 335
ILE A 348
 None
 0.87A 4a9jB-2cb1A:
undetectable		 4a9jB-2cb1A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 5 VAL A 389
LEU A 333
LEU A 335
ILE A 348
 None
 0.92A 4a9jC-2cb1A:
undetectable		 4a9jC-2cb1A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 ILE A 330
LEU A 185
GLY A 180
PHE A 179
ALA A 284
 None
 1.10A 4eb4A-2cb1A:
undetectable		 4eb4A-2cb1A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 LEU A 185
GLY A 180
PHE A 179
TYR A   3
ALA A 280
 None
 0.98A 4eb4A-2cb1A:
undetectable		 4eb4A-2cb1A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 ILE A 330
LEU A 185
GLY A 180
PHE A 179
ALA A 284
 None
 1.14A 4eb4B-2cb1A:
undetectable		 4eb4B-2cb1A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 LEU A 185
GLY A 180
PHE A 179
TYR A   3
ALA A 280
 None
 1.02A 4eb4B-2cb1A:
undetectable		 4eb4B-2cb1A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 8 ASN A 151
GLY A 106
THR A 108
GLY A  80
 None
None
None
PLP  A1202 (-3.0A)
 0.79A 4fo4B-2cb1A:
undetectable		 4fo4B-2cb1A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 LEU A 333
VAL A 389
ALA A 347
LEU A 356
THR A 361
 None
 1.49A 4iarA-2cb1A:
undetectable		 4iarA-2cb1A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 7 LEU A 185
GLY A 180
PHE A 179
TYR A   3
 None
 0.83A 4iqqC-2cb1A:
undetectable		 4iqqC-2cb1A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 8 LEU A 185
GLY A 180
PHE A 179
TYR A   3
 None
 0.88A 4iqqD-2cb1A:
undetectable		 4iqqD-2cb1A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 8 ALA A 263
PRO A 266
GLU A  62
LEU A 257
 None
 0.98A 4jjkA-2cb1A:
undetectable		 4jjkA-2cb1A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 8 VAL A 389
LEU A 333
LEU A 335
ILE A 348
 None
 0.82A 4lzrA-2cb1A:
undetectable		 4lzrA-2cb1A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 GLY A 103
LEU A 374
GLN A  81
THR A  84
PHE A 145
 None
None
PLP  A1202 (-4.5A)
None
None
 1.47A 4p6xG-2cb1A:
undetectable		 4p6xG-2cb1A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 9 PHE A 405
LEU A 401
VAL A 389
VAL A 391
LEU A 345
 None
 1.30A 4wnvA-2cb1A:
0.0		 4wnvA-2cb1A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		3 / 3 THR A 254
HIS A 194
LEU A  91
 None
 0.80A 5axdA-2cb1A:
2.6		 5axdA-2cb1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		3 / 3 THR A 254
HIS A 194
LEU A  91
 None
 0.83A 5axdC-2cb1A:
undetectable		 5axdC-2cb1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 VAL A  98
GLY A  95
ARG A  93
CYH A 260
LEU A  89
 None
 1.20A 5ergB-2cb1A:
3.1		 5ergB-2cb1A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 4 LEU A  22
LEU A  12
GLY A  11
GLU A  63
 None
 1.27A 5hhjA-2cb1A:
undetectable		 5hhjA-2cb1A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 VAL A 196
LEU A 189
ALA A  90
GLY A 213
ALA A 214
 None
 1.00A 5jw1A-2cb1A:
undetectable		 5jw1A-2cb1A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 VAL A 174
TRP A 223
ALA A  71
ALA A  87
LEU A  88
 None
 0.95A 5kirA-2cb1A:
undetectable		 5kirA-2cb1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 VAL A 174
TRP A 223
ALA A  71
ALA A  87
LEU A  88
 None
 1.04A 5kirB-2cb1A:
undetectable		 5kirB-2cb1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 7 LEU A 185
GLY A 180
PHE A 179
TYR A   3
 None
 0.88A 5nooB-2cb1A:
undetectable		 5nooB-2cb1A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 6 LEU A 185
GLY A 180
PHE A 179
TYR A   3
 None
 0.86A 5nooC-2cb1A:
undetectable		 5nooC-2cb1A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 8 LEU A 185
GLY A 180
PHE A 179
TYR A   3
 None
 0.84A 5nooD-2cb1A:
undetectable		 5nooD-2cb1A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 TYR A 308
ALA A 316
ALA A 320
LEU A 185
MET A 286
 None
 1.23A 5tl8A-2cb1A:
undetectable		 5tl8A-2cb1A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 ILE A 330
LEU A 185
GLY A 180
PHE A 179
ALA A 284
 None
 1.11A 5x5qB-2cb1A:
undetectable		 5x5qB-2cb1A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		6 / 12 LEU A 185
GLY A 180
PHE A 179
TYR A   3
ALA A 280
ASP A 314
 None
 1.42A 5x66A-2cb1A:
undetectable
5x66B-2cb1A:
undetectable		 5x66A-2cb1A:
23.81
5x66B-2cb1A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 9 ILE A 330
LEU A 185
GLY A 180
PHE A 179
ALA A 284
 None
 1.12A 5x66C-2cb1A:
undetectable		 5x66C-2cb1A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 ILE A 330
LEU A 185
GLY A 180
PHE A 179
ALA A 284
 None
 1.14A 5x66F-2cb1A:
undetectable		 5x66F-2cb1A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 LEU A 185
GLY A 180
PHE A 179
TYR A   3
ALA A 280
 None
 0.98A 5x66F-2cb1A:
undetectable		 5x66F-2cb1A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 TYR A 308
ALA A 316
ALA A 320
LEU A 185
MET A 286
 None
 1.23A 6aybA-2cb1A:
undetectable		 6aybA-2cb1A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		5 / 12 TYR A 308
ALA A 316
ALA A 320
LEU A 185
MET A 286
 None
 1.20A 6aycA-2cb1A:
undetectable		 6aycA-2cb1A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		3 / 3 ARG A  41
PHE A  42
GLY A  38
 None
 0.76A 6fgdA-2cb1A:
undetectable		 6fgdA-2cb1A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE
(Thermus
thermophilus) 		4 / 6 ARG A  64
ALA A   7
LEU A   6
ALA A  67
 None
 1.12A 6fosB-2cb1A:
undetectable		 6fosB-2cb1A:
8.77