SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cb3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 2cb3 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-LE
(Drosophila
melanogaster) 		4 / 8 ILE A 222
LEU A 221
GLY A 277
GLY A 245
 None
None
GOL  A1344 (-3.6A)
None
 0.75A 2wd9B-2cb3A:
undetectable		 2wd9B-2cb3A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 2cb3 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-LE
(Drosophila
melanogaster) 		5 / 12 GLY A 265
ASN A 267
ASN A 318
CYH A 315
LEU A 205
 None
MLD  A1345 (-3.2A)
MLD  A1345 (-3.2A)
None
MLD  A1345 ( 4.6A)
 1.35A 3ooiA-2cb3A:
undetectable		 3ooiA-2cb3A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2cb3 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-LE
(Drosophila
melanogaster) 		5 / 12 CYH A 315
ASN A 339
LEU A 311
VAL A 203
ILE A 204
 None
 1.33A 4k36B-2cb3A:
undetectable		 4k36B-2cb3A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2cb3 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-LE
(Drosophila
melanogaster) 		5 / 12 GLY A 253
ARG A 254
ASN A 218
LEU A 243
THR A 209
 None
MLD  A1345 (-3.0A)
None
None
None
 1.42A 5fhzA-2cb3A:
undetectable		 5fhzA-2cb3A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 2cb3 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-LE
(Drosophila
melanogaster) 		5 / 11 GLY A 265
ASN A 267
ASN A 318
CYH A 315
LEU A 205
 None
MLD  A1345 (-3.2A)
MLD  A1345 (-3.2A)
None
MLD  A1345 ( 4.6A)
 1.35A 5updA-2cb3A:
undetectable		 5updA-2cb3A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 2cb3 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-LE
(Drosophila
melanogaster) 		5 / 11 GLY A 265
ASN A 267
ASN A 318
CYH A 315
LEU A 205
 None
MLD  A1345 (-3.2A)
MLD  A1345 (-3.2A)
None
MLD  A1345 ( 4.6A)
 1.38A 6cenA-2cb3A:
undetectable		 6cenA-2cb3A:
21.22